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Showing 1 to 20 of 45 for “"Sulfation"”.
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Tyrosine Sulfation in A431 Cells
… which opened a door towards enzyme purification Sulfation of proteins on tyrosine residues has recently been shown as a widespread occurrence. Most of the known tyrosine sulfated proteins are secretory proteins. The tyrosine sulfotransferase activity was suggested to be localized to the Golgi …
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Poisoning and Sulfation on Vanadia SCR Catalyst
… lab-scale investigations involved poisoning and sulfation of SCR vanadia/titania catalysts synthesized with an incipient impregnation method. In situ FTIR spectroscopy indicate that K, Na, and Ca (among others materials) reduce, and sulfation and tungsten increase ammonia adsorption intensity on …
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… motifs. In this thesis, “Modifying Chondroitin Sulfation Enhances Retinal Ganglion Cell Axon Regeneration,” I, Craig Pearson, seek to determine the time course and spatial distribution of CSPG accumulation in the glial scar following acute injury, and then to demonstrate that ARSB is effective …
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The sulfation of limestone and calcium oxide : direct and series reaction
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1986.
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Structural Studies on the Regulation of Sporulation in Bacillus and Antibiotic Sulfation
<p>The microbial world is rich with complexity. Bacteria have evolved several mechanisms to help them survive the harshest environments on earth. These range from complex developmental transformations to the synthesis of small molecule antibiotics that can fend off competing species. Both of these …
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Recycling neodymium-iron-boron magnet alloy by direct sulfation with SO₂ gas
… to recycle this electronic waste. Selective sulfation has been used to separate the neodymium from the iron in permanent magnets. Sulfuric acid is used to convert the metals to sulfates, which are then roasted to produce a calcine of neodymium sulfate and iron oxide. The calcine could then be …
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Pulse charging lead-acid batteries to improve performance and reverse the effects of sulfation
… this is a phenomenon generally referred to as sulfation. One possible method that has been proposed by many to reverse the effects of sulfation is to recharge the lead-acid battery using a pulse charger. To gain a better understanding of the possible benefits of this type of charging, a pulse …
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Glycosidic Modification and Sulfation of Polymeric Surfaces and their Influence on Blood Compatible Properties
Polymeric surfaces were modified and the impact on the blood compatible properties investigated.
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Characterisation of the sulfotransferases catalysing the sulfation of xenobiotics and steroids in bovine liver
… of safer animal derived food products to man. Sulfation catalysed by sulfotransferases (SULTs) is an important phase 2 drug metabolising reaction. It is not only involved in the detoxification of drugs and xenobiotics but also in the bioactivation of procarcinogens. It is also important in the …
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Knockdown of Heparan Sulfate Via NDST1 knockout Does Not Inhibit Mouse Aortic Endothelial Cell Alignment In-Vivo
… cells. An investigation into the role of NDST1 sulfation of heparan sulfate (HS), a key component of many proteoglycans which make up the GCX, was conducted. The descending aortas (DAs) of transgenic mice with conditional knockouts (KOs) of NDST1 in vascular ECs were quantified for changes in …
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ASSESSMENT OF THE FEASIBILITY OF CO-ADMINISTRATION OF PHENOLIC DIETARY COMPOUNDS WITH PHENYLEPHRINE TO INCREASE ITS BIOAVAILABILITY
… oral bioavailability (38 ± 9%, mean ± SD). Sulfation plays a very important role in pre-systemic metabolism of PE. The sulfation of PE occurs at its phenolic group, which is the preferred structural feature of many sulfotransferase (SULT) substrates. Compounds with phenolic groups have …
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CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF CHONDROITIN SULFATE DISACCHARIDES
… and structural complexity. To probe the ?sulfation code? in CS, a synthetic strategy was devised to obtain all 16 theoretically possible sulfation patterns in the CS repeat unit. The strategy incorporates orthogonal protecting groups in glucuronic acid and N-acetyl galactosamine precursor …
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ΜΗΧΑΝΙΣΜΟΣ ΘΕΙΩΣΗΣ ΜΑΡΜΑΡΟΥ ΣΕ ΧΑΜΗΛΕΣ ΘΕΡΜΟΚΡΑΣΙΕΣ ΚΑΙ ΧΑΜΗΛΕΣ ΣΥΓΚΕΝΤΡΩΣΕΙΣ ΣΕ ΔΙΟΞΕΙΔΙΟ ΤΟΥ ΘΕΙΟΥ ΚΑΙ ΠΡΟΣΤΑΣΙΑ ΑΠΟ ΤΗ ΘΕΙΩΣΗ ΚΑΙ ΤΗΝ ...
… PRESENT WORK HAS BEEN THE INVESTIGATION OF THE SULFATION MECHANISM AT LOW SO2 CONCENTRATION AND LOW TEMPERATURES AND THE TESTING OF NEW PROTECTIVE MATERIALS. WE HAVE MEASURED CONTINIOUSLY (QUARTZ, SPIRAL MICROBALANCE) THE SULFATION RATE ON POWDERED CACO3 P.A AT 475 C WITH VARIATION OF THE SO2 …
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Synthesis and application of specifically sulfated carbohydrates containing methacrylate functionality
… also investigated the effect of the degree of sulfation of these polymers upon their interactions with bacteria such as Staphylococcus biological activities. A second area of this thesis is investigation of the potential for these novel sulfated polymers to act as biomimics of natural sulfated …
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Molecular studies of aggrecan : experiments and simulations
… (MD) Simulations. It has been found that the sulfation type (4- versus 6-sulfation) and sulfation pattern vary with age in articular cartilage and intervertebral disc. This MD simulation study developed an implicit solvation model of three types of tetrasaccharides of both sulfated and …
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FROM GENE TO STRUCTURE: Formation of Iduronic Acid in Dermatan Sulfate by Two DS-epimerases
… The former are also commonly associated with sulfation in the 4-O-position of N-acetylgalactosamine suggesting that there is interplay between sulfation and epimerization. In this thesis it is shown that both epimerases are simultaneously needed together with the sulfotransferase D4ST-1 to …
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Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
… protein binding will be extensive and linear; 4) Sulfation will be the major metabolic pathway for 2ME2.This was a phase I dose escalation study. Twenty patients with refractory solid tumors were enrolled. 2ME2 was administered orally starting at 400 mg bid with dose escalation upto 3000 mg bid. …
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Heparan sulfate glycosaminoglycan regulation of vasculogenesis
… that the chemical composition of HSGAG sulfation patterns change with differentiation. Perturbation of HSGAG structure by chemical, enzymatic, or genetic modification effectively inhibited vasculogenesis. Genetic silencing of HSGAG modifying enzyme, N-deacetylase/N-sulfotransferase-1, …
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Cartilage mechanobiology : the effects of loading on the fine structure and function of chondroitin sulfate glycosaminoglycans
… been shown to have a significant effect on the sulfation pattern and chain length and number in cartilage explant studies. The mechanisms that govern these alterations, however, have not been determined. The purpose of this study is to examine the effects of mechanical compression on chondroitin …
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