Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 581 for “"Structure Function"”.
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Structure-function relationships of metalloenzymes
Anhand der Modellsysteme [NiFe] Hydrogenase und Superoxid Reduktase wurden Struktur-Funktionsbeziehungen von Metalloenzymen, die die Umwandlung kleiner Moleküle katalysieren, mittels theoretischer und spektroskopischer Methoden analysiert. Der erste Teil dieser Arbeit ist der Charakterisierung …
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Evolution of protein structure function
… These experiments are constrained by proteins structure and function. Investigating genomics data is a natural way for mining these constraints to address long-standing biological challenges. In this dissertation, first, we tried to address two specific biological questions by reconstructing …
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Structure, Function & Dynamics At The Membrane
… necessary for maintaining a single tertiary structure.
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Trpv5: Structure, Function And Drug Discovery
… on TRPV5 which yielded the first reported structure of this protein. From that structure we were able to identify the econazole binding site and gain insights into how binding of a modulator in that pocket would result in channel inhibition. We then sought to elucidate the mechanism of …
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Decoding structure-function relationships of glycans
… glycan-protein interactions, elucidating glycan structure-function relationships is challenging. Thus, uncovering the biological function of glycans requires an integrated approach, incorporating structural analysis of glycans, and glycan-proteins interactions with functional analysis. In this …
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Structure/function studies of protein phosphatases
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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Structure-function studies of bovine rhodopsin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Structure-function Analysis of the STRIPAK Complex
… My project focused on the structural and functional characterization of STRIPAK. I mapped direct interactions and interacting regions on these proteins and determined that the PP2A substrate binding subunit (striatin) and CCM3 act as adapter molecules to bridge the kinase and phosphatase …
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Structure-Function Analysis of Insect Olfactory Receptors
… on understanding how the insect olfactory system functions at the periphery, shedding light on the molecular players involved and the interactions between environmental chemicals and OSNs. In Drosophila, most of the ~1,200 OSNs express members of the olfactory receptor (OR) protein family …
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UNCOVERING STRUCTURE-FUNCTION RELATIONSHIPS IN CHROMATIN ARCHITECTURE
… thus, genome folding architecture plays a functional role in replication. Finally, as part of the 4D-Nucleome consortium analysis, we integrate genome folding with other features of nuclear spatial positioning (SPIN states) and transcription. We show a common unifying trend amongst these …
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Structure-function studies of SLC15 peptide transporters
… and di- and tri- peptides and drugs similar in structure (peptidomimetics). PepT1, and to a lesser extent PepT2, have therefore gained attention due to their role in determining the absorption, retention and elimination of transported drugs. In this study three novel prodrug-carriers namely …
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Structure-function analysis of phototropin receptor kinases
… mode of phototropin autophosphorylation and the functionality of a mutated phototropin 1 which demonstrates increased autophosphorylation activity in this system is assessed in planta using transgenic Arabidopsis. It was initially of interest to further evaluate the mode of phototropin …
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Structure-function analysis of 11β-hydroxysteroid dehydrogenase
… key enzyme in the conversion of cortisone to the functional glucocorticoid hormone cortisol. This activation has been implicated in several human disorders, notably the metabolic syndrome where 11β-HSD1 has been identified as a novel target for potential therapeutic drugs. Crystal structures have …
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Measurement of fifth structure function in deuterium
… the first measurement of f'01, the so called 5th structure function, in deuterium. In conjunction with deuterium, this structure function was measured under identical kinematics in carbon. These measurements constitute the first ever observations of these novel structure functions and the …
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Structure-function relationships in monotopic phosphoglycosyl transferases
Complex glycans play essential roles in prokaryotic and eukaryotic biology. While this ubiquitous post-translational modification takes a diversity of forms, many glycoconjugate biosynthesis pathway across domains of life follows a common logic. Glycan assembly is initiated by a phosphoglycosyl …
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Structure-function relationships in human brain development
The integration of anatomical, functional, and developmental approaches in cognitive neuroscience is essential for generating mechanistic explanations of brain function. In this thesis, I first establish a proof-of-principle that neuroanatomical connectivity, as measured with diffusion weighted …
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Nanocomposite Dispersion: Quantifying the Structure-Function Relationship
… overlooked when relating the effect of nanoscale structures on functional performance and processing/property relationships for nanocomposite materials. This is due in part to the difficulty in visualizing the nanoinclusion and ambiguity in the description of dispersion. Understanding the …
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Structure-Function Studies on Two Phosphoenolpyruvate Carboxylases
… and C₄ plants via Rubisco. We are studying the structure-function aspects of both enzymes, with a goal of discovering new elements in these enzymes which can modulate catalysis. We have undertaken an interdisciplinary approach for this work and have shown that a combination of experimental and …
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