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Showing 1 to 20 of 243 for “"Smooth Muscle Cells"”.
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Direct Reprogramming of Fibroblasts into Smooth Muscle Cells
The generation of induced pluripotent stem (iPS) cells is a useful tool for regenerative medicine. However, the risk of tumor development of the aforementioned cells should be addressed before they can be used for clinical applications. During the reprogramming process a number of signal pathways …
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Tensile Properties of Single Vaginal Smooth Muscle Cells
… level. In this study, we tested single vaginal smooth muscle cells (SMCs) to quantify their elastic moduli. Cells were enzymatically isolated from vaginal walls of freshly sacrificed, virgin Long Evans rats and cultured using well-established methods. A custom-built experimental setup was used …
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Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
Inflammation causes proliferation of intestinal smooth muscle cells (ISMC), contributing to the thickened intestinal wall and the dysmotility symptoms observed in inflammatory bowel disease (IBD). A unique consequence of Crohn’s disease (CD), a subset of IBD characterized by chronic, transmural …
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Effects of heparinoids on bovine aortic smooth muscle cells
Smooth muscle cells (SMCs) comprise the bulk of the tunica media of all blood vessels. Upon injury to the overlying endothelial monolayer of blood vessels, SMCs proliferate into the lumen of the vessel and cause dangerous occlusions. The glycosaminoglycan (GAG) heparin has been shown to be …
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
… function in atherosclerosis and vascular smooth muscle cells Johannes Reinhold Atherosclerosis is the leading cause of death in the Western world. Although mitochondrial DNA (mtDNA) damage has been implicated in atherosclerosis, it is unclear whether the damage is sufficient to impair …
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Biosynthesis and degradation of proteoglycans in cultured smooth muscle cells
Smooth muscle cells isolated from neonatal rat hearts synthesize and secrete radioactively labelled proteoglycans into two distinct extracellular compartments, the pericellular (cell surface/matrix layer) and the culture medium (extracellular). Cultures grown in the presence of ascorbic acid …
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Non-enzymatic glycation modifies binding of fibronectin to arteriolar smooth muscle cells /
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.]
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The Effects of Smooth Muscle Cells on Engineered Microvasculatures in Fibrin Hydrogels
… are comprised of two cell types: the endothelial cells (ECs) which line the lumen of the capillary, and the supporting pericytes which are closely apposed to the abluminal surface of the capillary wall (sometimes called mural cells). These pericytes are phenotypic derivations of mesenchymal organ …
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Investigations into the molecular regulation of gene expression in airway smooth muscle cells
The phenotype of airway smooth muscle (ASM) differs in asthmatic patients compared to healthy individuals. Hyperplasia, hypertrophy, increased contraction and altered synthetic capabilities of asthmatic airway smooth muscle cells (ASMCs) have all been reported, however, the molecular mechanisms …
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Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells
… regulation, and protein interactions, and most cells express multiple isoforms. We hypothesized that cAMP produced by different AC isoforms regulates unique cellular responses. Overexpression of individual isoforms had distinct effects on forskolin (Fsk)-induced expression of a number of known …
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Stiffness of vascular smooth muscle cells from aged primates measured using reconstituted tissue model
… contribution from stiffening of the vascular smooth muscle cells (VSMCs) with age. VSMCs previously obtained from young and old monkeys (macaca fascicularis) were seeded into a collagen gel to form a reconstituted tissue. The aim of this study was to quantitatively characterize the mechanical …
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Reoxygenation of hypoxic coronary smooth muscle cells amplifies growth-retarding effects of ionizing irradiation
Hypoxic coronary smooth muscle cells (HCSMCs) are potential targets for brachytherapy to prevent restenosis after percutaneous transluminal angioplasty. It is unclear whether gene expression, apoptosis rate and production of reactive oxygen species of these cells undergoing alpha-irradiation are …
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Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
… of extracellular matrix by human coronary artery smooth muscle cells (hCASMCs) and cytokines involved in inflammation. Insulin-like growth factor (IGF-i) is one of the most potent inducers of proliferation in hCASMCs, mainly through the activation of phosphatidyl inositol3 (Pl3)-Kinase and mitogen …
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Electrical Properties and the Sodium, Potassium, and Chloride Content of Intestinal Smooth Muscle Cells
Made available in DSpace on 2014-12-05T22:14:39Z (GMT). No. of bitstreams: 1 5900469.pdf: 4006299 bytes, checksum: 5200802e70074f1d4c614d25da06996e (MD5) Previous issue date: 1958
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The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection
… Among other cell types, IL-4Ra responsive smooth muscle cells influence immunological responses and are needed for host protection during N. brasiliensis and S. mansoni infection.
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