Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Sirtuin"”.
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Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
BACKGROUND: Sirtuin-1 (SirT1), an NAD+-dependent deacetylase, is associated with cellular protective effects and beneficial metabolic processes that mimic caloric restriction, increasing cellular stress resistance. Recent studies have shown that SirT1 anti-inflammatory and anti-oxidant effects on …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… TAZ are largely unclear. Here we have identified Sirtuin 6 (SIRT6), an NAD+ dependent deacetylase, as a key epigenetic regulator in the protection against hepatic fibrosis by suppressing the YAP/TAZ activity. SIRT6 has been previously implicated in the regulation of the canonical transforming …
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The Role of Sirtuin Inhibitors on the Proteomic Responses of the Mussels Mytilus galloprovincialis and Mytilus trossulus to Menadione Induced Oxidative Stress
… detoxify ROS. Additionally, we hypothesize that sirtuins (SIRT; a family of NAD-dependent deacetylases) might be involved in the regulation of this metabolic transition. To test the latter, a discovery approach will be used to analyze the proteomic response of <em>M. galloprovincialis </em>and …
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Elucidation of the molecular pathways of lifespan extension by dietary restriction in yeast
… pleiotropy view of aging, reveal the illusion of sirtuin mediated longevity in 32 long lived alleles (hopefully steering the field farther from sirtuin research and toward more interesting things), show that there is indeed a conserved aging factor between CLS and RLS, indicate that aging in yeast …
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Biochemical and structural characterization of Sirtuins from mammals and Thermotoga maritima
Sirtuins are NAD+ dependent protein deacetylases involved in regulation of metabolism, age related diseases and are suggested to mediate lifespan extending effects of calorie restriction. Mammals contain seven Sirtuin soforms with various cellular localizations and substrate preferences. This work …
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Biochemische und molekularbiologische Charakterisierung von RAIP, einem neuen ER-lokalisierten proapoptotischen Protein
… von drei Interaktionspartnern (Ferritin, SRp40, SIRTUIN 7).
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Regulation of Mitochondrial Sirtuins Sirt3 and Sirt5 by Small Molecules
Sirtuins are a highly conserved family of protein deacylases that are important regulators of metabolism, longevity and aged-related diseases. There are seven sirtuin isoforms in mammals with different subcellular localization, substrates and biological functions. Three sirtuin isoforms, Sirt3-5, …
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A Study Of Novel Activities Of Type Iii Sirtuins: Cobb And Pfsir2A
Sirtuins are a class of nicotinamide adenine dinucleotides (NAD)-dependent histone deacetylases (HDACs) found in all three domains of life. Acetylation-deacetylation of histones lysine residues is an accepted paradigm for gene regulation in eukaryotes. In recent years, proteonomic studies revealed …
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NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… Inhibition of the NAD<super>+</super>-dependent sirtuin deacetylases by Sirtinol treatment, or SIRT1/SIRT3 knockdown, phenocopied the effects of Nampt blockade on fatty acid synthesis thereby suggesting that Nampt maintains lipogenesis through sirtuin-dependent mechanisms. Additionally, we made …
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Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms
… histone H3 and H4. This effect is dependent on sirtuin histone deacetylases (HDACs), as inactivation of these enzymes, specifically Hst4, rescues the acetylation defect. We also find that this sirtuin-mediated deacetylation response requires a functional protein phosphatase 6 complex (PP6). PP6 …
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The Dynamic Streptococcus Pyogenes Transcriptome in the Host Cell Environment and Contributions by Phage
… screen. The first spy1215 encodes a sirtuin-like deacetylase that is homologous to a repressor of virulence in the malarial parasite Plasmodium falciparum. Our work presents the first evidence of a direct link between a bacterial sirtuin (Spy1215) and virulence regulation. …
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METABOLISM-COUPLED PROTEIN POST-TRANSLATIONAL MODIFICATIONS IN C. ELEGANS AND MAMMALIAN MODELS
… and a knock-out mutant of the mitochondrial sirtuin sir-2.3. N-acylspermidines were found to be downstream of mitochondrial sirtuin function and have negative impacts on C. elegans lifespan and cancer cell proliferation. The third chapter focuses on protein fatty acylation in C. elegans, …
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Regulation of AMPA receptor acetylation and translation by SIRT2 and AMPK: the molecular mechanisms and implications in memory formation
… protein kinase (AMPK) and sirtuin 2 (SIRT2), are described. It is shown that SIRT2, a NAD+-dependent protein deacetylase, directly controls AMPAR stability by regulating AMPAR acetylation. For the first time, we discovered that AMPARs are subject to lysine acetylation, a …
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Mdm2-Mediated Degradation of Sirt6 Phosphorylated By Akt1 Promotes Tumorigenesis and Trastuzumab Resistance In Breast Cancer
<p>Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is …
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Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage
… drives poly (ADP-ribose) polymerase (PARP) and sirtuin (SIRT) reactions, can be compromised and strategies for overcoming this limitation in the vasculature do not exist. This study determines if nicotinamide riboside (NR) delivery can augment NAD+ stores and fuel resistance to oxidative stress. …
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SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
… we determined whether enhancing the activity of sirtuin 1 (SIRT1) would be beneficial in maintaining heart health in Chagas disease. We found that treatment with SIRT1 agonists, given in a therapeutic window of time after Trypanosoma cruzi infection, had no beneficial effects in reducing the …
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Bioinformatik-Strategien zur Analyse regulatorischer RNA-Motive und ihre experimentelle Validierung
… Rab1A 3'UTRs verschiedener Vertebraten und der Sirtuin 2[alpha] 3'UTR von Mensch und Maus vorkommt. Experimentelle Analysen im Rahmen der vorliegenden Arbeit konnten Hinweise auf eine biologische Funktion des vorhergesagten Stemloops in der Rab1A 3'UTR liefern. Die Ergebnisse von …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… we identified uncoupling protein 2 (UCP2) and Sirtuin 3 (Sirt3) as important mediators of the anti-inflammatory phenotype in FABP4 deficient macrophages. Increased expression of UCP2 in FABP4 null macrophages contributes to both suppressed inflammation and endoplasmic reticulum stress (ER …
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Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer
… dinucleotide (NAD+) dependent deacetylase Sirtuin 1 (SIRT1) in this impairment of mitophagy/autophagy. Crucially we observed strong support for these key findings in human cancer, where PNC1 expression is inversely correlated with markers of hypoxia signalling, and positively correlated …
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Study of the Cellular Role of GRP78/BiP mono-ADP-ribosylation in UPR and Cancer
… of enzymes: ARTCs, ARTDs, and members of the sirtuin family. In the present study, hARTC1-mediated mono-ADP-ribosylation was investigated in terms of the cellular compartments involved, target(s) and roles. The collected results demonstrated that hARTC1 protein and enzymatic activity is mainly …
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