Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"Sirt1"”.
-
Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
… studies have focused attention on Sirtuins. SirT1 plays a role in synaptic plasticity, learning and memory. Additionally, it has been demonstrated to reduce Aβ accumulation and elevate α-secretase activity. ApoE4 has been suggested to decrease SirT1. SirT1 suppresses AD in cells, primary …
-
Estrogen signaling interacts with Sirt1 in adipocyte autophagy
… (e.g., ERα) and energy sensing factors (e.g., Sirt1) control metabolism and prevent adiposity, and in which they have been shown to play collaborate roles. However, how autophagy is involved in ERα and Sirt1's inhibitory roles on adiposity is unknown. These questions have been addressed in my …
-
Úloha SIRT1 během zrání oocytů v podmínkách in vitro
SIRT1 histone deacetylase acts towards many epigenetic and non-epigenetic targets. The involvement of SIRT1 in oocyte maturation is assumed and the importance of ooplasmic SIRT1 pool for further destiny of matured oocyte is strongly suggested. We hypothesized that SIRT1 play role of the signal …
-
Design of nanoplatforms for ocular delivery of SIRT1 agonists in diabetic retinopathy [Progettazione di nanopiattaforme per la somministrazione oculare di agonisti di SIRT1 nella retinopatia diabetica]
… ossidativo e dell'infiammazione. La sirtuina 1 (SIRT1), una proteina istone deacetilasi, agisce come un regolatore cruciale delle risposte cellulari allo stress e svolge un ruolo fondamentale nella protezione dei tessuti oculari, come il nervo ottico e la retina. La ridotta espressione di SIRT1 …
-
SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
… and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, C57BL/6 mice were infected with Trypanosoma cruzi (Tc), treated with SIRT1 agonists …
-
Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme
… or deacylase activity, including deacetylase. SIRT1 is the most studied mammalian Sirtuins and predominantly localised in the nucleus and cytoplasm. Many Sirtuins targets are involved in cancer and in many types of cancers, SIRT1 is found to be overexpressed. Recent observations support SIRT1 …
-
SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
… in age-related or post-menopausal osteoporosis. SirT1, the mammalian orthologue of yeast Sir2, has been shown to be a negative regulator of PPAR[gamma] and NF[kappa]B, two transcription factors important for the differentiation of osteoblasts and osteoclasts, respectively. Here, we show that …
-
NAD+-DEPENDENT SIRT1 REPROGRAMS CD11C+ DENDRITIC CELLS AND CD4+ T CELLS TO CONTROL IMMUNE POLARITY DURING SEPSIS
… on innate and adaptive immunity. In our model, SIRT1 activation acts through CD11c+ tolerogenic dendritic cells and their support of TGFβ and IL-10 secretions from CD4+ TReg cells as contributors to sepsis immunosuppression. That SIRT1 drives this innate and adaptive immune link is supported by …
-
Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
BACKGROUND: Sirtuin-1 (SirT1), an NAD+-dependent deacetylase, is associated with cellular protective effects and beneficial metabolic processes that mimic caloric restriction, increasing cellular stress resistance. Recent studies have shown that SirT1 anti-inflammatory and anti-oxidant effects on …
-
Biochemical and structural characterization of Sirtuins from mammals and Thermotoga maritima
… emphasis on the largest member of the family, Sirt1.Analysis of various Sirt1 constructs using analytical ultracentrifugation and electron microscopy techniques identified it to be a monomer, similar to other mammalian isoforms. Comparison of activity between different Sirt1 constructs …
-
Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… the functions of two lysine deacetylases, SIRT1 and HDAC1, in the neuronal response to DNA double strand breaks (DSBs). Both SIRT1 and HDAC1 were previously shown to promote neuronal survival in a mouse model of neurodegeneration in which the appearance of DSBs precedes other neurotoxic …
-
The Role of Resveratrol and Sirtuin1 in Skeletal Muscle Under a Nutrient Stress
… Interestingly, the activation of Sirtuin1 (SIRT1) has been reported during DR and its reduction abrogates lifespan extension. Importantly, SIRT1 activation via resveratrol treatment has been indicated to be important in the presence of inflammatory stress (TNF-α) (Saini et al., 2012). …
-
Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
… muscle repair and regeneration. The sirtuin 1 (Sirt1) protein, a histone deacetylase, has been shown to be involved in many cellular processes, including the differentiation of myoblasts. Although Sirt1 is noted for its role in the differentiation of myoblasts, it is not known if it directly …
-
HIF-2: Standing Guard at the Crossroads of Stress and Aging
… deacetylase enzyme Sirtuin 1, also known as Sirt1 or silent mating type information regulator 2 (Sir2) homolog 1, selectively stimulates HIF-2 alpha signaling during hypoxia. In lower organisms and cell culture models, the FoxO family of transcription factor regulates the transcription of …
-
The Pathophysiological Importance of Nicotinamide Phosphoribosyltransferase as a Key NAD Biosynthesis Enzyme in Metabolic Homeostasis
… have demonstrated that deacetylation on NAMPT by SIRT1 controls its secretion from adipocytes. iNAMPT is acetylated in both brown and white adipose tissues, and the level of acetylation of iNAMPT is decreased during fasting when Sirtuins are activated. We also found that enhancement of eNAMPT …
-
Heat stress: A risk factor for skin carcinogenesis
… stress has been linked with increased Sirtuin1 (SIRT1) protein activity. SIRT1 is an important histone deacetylase that helps maintain chromosomal integrity but can also induce post-translational modifications of the p53 protein. By mediating deacetylation of the p53 protein, SIRT1 can diminish …
-
Mechanisms Regulating Amyloid Processing Enzymes in HIV-Associated Neurotoxicity
… decreased levels of both ADAM10 and Sirtuin1 (SIRT1), an enzyme shown to regulate ADAM10 levels, in primary neurons. Both ADAM10 and SIRT1 reductions were mediated through NMDA receptors. Furthermore, SIRT1 protein levels decreased earlier than ADAM10 and this early SIRT1 reduction was via …
-
Regulation of Mitochondrial Sirtuins Sirt3 and Sirt5 by Small Molecules
… found in red wine, was reported to activate Sirt1. Testing resveratrol and its related compounds including piceatannol, polydatin, 4’-bromo-resveratrol against Sirt3 showed an inhibitory effect. Among these compounds, brRESV is the most potent Sirt3 inhibitor. Crystal structures of Sirt3 in …
-
Peripubertal Binge Ethanol, Age and Sex Modulate Microrna Expression in the Ventral and Dorsal Hippocampus of the Adolescent Rat
… neurotrophic factor (BDNF) and sirtuin 1 (SIRT1) are differentially expressed in the ventral hippocampus dependent on age and 17β-estradiol (E<sub>2</sub>). We examine whether microRNA expression, microRNA biogenesis enzymes Drosha and Dicer, and microRNA target genes BDNF and SIRT1 …
-
Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage
… on viability and DNA repair were abrogated upon SIRT1 knock-down (KD). SIRT6 KD was similarly implicated in NR-mediated DNA repair. Furthermore, NR delivery protected against oxidative-stress-induced senescence. This protection was partially lost by SIRT1 KD. NR delivery protects vascular cells …
Page 1 of 3