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Showing 1 to 20 of 86 for “"Siderophore"”.
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Siderophore cycling in the North Pacific Subtropical Gyre
… some heterotrophic bacteria are able to produce siderophores, which are small organic ligands with extraordinarily high stability constant for Fe(III), to facilitate Fe uptake. The recently developed mass spectrometry based techniques allow for the characterization and quantification of …
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Molecular Recognition in Host-Guest Ionophore-Siderophore Assemblies
… substituted protonated amines and the iron siderophore ferrioxamine B is presented. Methodology was developed using ESI-MS to successfully quantitate host-guest interactions in binary and complex mixtures. Binding constants were obtained in the range of log Ka = 3 - 5 and correspond to …
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Exploring Siderophore-Mineral Interaction Using Force Microscopy and Computational Chemistry
… forces of interaction were measured between the siderophore azotobactin and the minerals goethite (FeOOH) and diaspore (AlOOH) in solution using force microscopy. Azotobactin was covalently linked to a hydrazide terminated atomic force microscope tip using a standard protein coupling technique. …
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Siderophore production by heterotrophic bacterial isolates from the Costa Rica Upwelling Dome
… about bacterial strategies for iron acquisition. Siderophore (Fe ligand) production by bacteria may play a major role in influencing the bioavailability of iron in the ocean. Despite the importance of siderophores in the environment, only limited information from a select group of bacteria is …
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Siderophore production by heterotrophic bacterial isolates from the Costa Rica upwelling dome
… about bacterial strategies for iron acquisition. Siderophore (Fe ligand) production by bacteria may play a major role in influencing the bioavailability of iron in the ocean. Despite the importance of siderophores in the environment, only limited information from a select group of bacteria is …
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Structural and Mechanistic Studies on N-Hydroxylating Monooxygenases Involved in Siderophore Biosynthesis
… L-lysine. This is the first, committed step to siderophore biosynthesis. Pathogenic microbes including Aspergillus fumigatus and Mycobacterium tuberculosis secrete these low molecular weight compounds in order to uptake FeIII from their hosts for their metabolic needs when establishing …
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SIDEROPHORE DESFERRIOXAMINE B PROMOTED DISSOLUTION AND ADSORPTION PROPERTIES OF TITANIUM DIOXIDE BEARING MINERALS
… scenario, small biomolecules known as microbial siderophores which are produced by many microorganisms such as yeast, fungi, algae, and bacteria in a low iron available environment play a significant role in iron availability. They can be found everywhere in nature and can sequester Fe(III) in a …
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EFFECTS OF COMPLEXATION WITH THE SIDEROPHORE DESFERRIOXAMINE B ON TRANSITION METAL REMOVAL FROM SEAWATER
… transition metals with the trihydroxamate siderophore desferrioxamine B (DFOB), representative of a class of small organic ligands that are exceptionally selective for Fe(III) and found in open ocean surface waters at low-picomolar concentrations. Stability constants for DFOB complexes with …
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Isolation of a Siderophore Produced by Methicillin-Resistant <em>Staphylococcus aureus</em> Strain H372.
… overcome these limitations bacteria have evolved siderophores. Siderophores are low molecular weight compounds that bind ferric iron with a high affinity. <em>Staphylococcus aureus</em> is an important human pathogen that is known to produce at least four siderophores, and these siderophores …
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Isolation and Identification of the Siderophore "Vicibactin" Produced by <em>Rhizobium leguminosarum</em> ATCC 14479.
<p>Siderophores are small, iron chelating molecules produced by many bacteria to help meet the iron requirements of the cell. Multiple metabolic functions require iron as it serves as a cofactor in many enzymes and cellular processes. However, in the presence of oxygen and at physiologic pH, iron …
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Iron Acquisition in <em>Rhodococcus erythropolis</em> Strain IGTS8: Characterization of a Mutant Strain that Over Produces Siderophore.
… by releasing small organic compounds called siderophores that bind and effectively solubilize iron so that it can be transported into the cell for growth. The focus of this study was to learn more about the iron acquisition and especially the transport of iron by the soil bacterium …
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Iron Acquisition in <em>Rhodococcus erythrolpolis</em>: the Isolation of Mutant(s) that Do Not Produce a Siderophore.
… strain IGTS8 releases a small compound called a siderophore, that scavenges ferric iron from the environment. To learn more about the genetic control of iron acquisition, mutant(s) defective in siderophore production were isolated. Mutants were generated, by inserting a mutagenic plasmid, …
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Iron Acquisition in <em>Rhodococcus erythropolis</em> Strain IGTS8: Characterization of a Mutant that Does Not Produce a Siderophore.
<p>N5-59, a siderophore deficient mutant strain of <em>Rhodococcus erythropolis</em> strain IGTS8 (IGTS8) was investigated to learn more about how this poorly characterized bacterium acquires iron. N5-59 cells were starved for iron and then lysed to release any intracellular siderophore. No …
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Isolation, Purification, and Chemical Characterization of the Dihydroxamate-Type Siderophore, "Schizokinen," Produced by <em>Rhizobium leguminosarum</em> IARI 917.
… Many bacteria have the ability to produce siderophores, low molecular weight compounds that have a high affinity for Fe<sup>3+</sup>. Siderophores are part of a multi-component system that actively transports the iron-siderophore complex into the cytoplasm. Rhizobia are characterized by …
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Rhizosphere competence, antibiotic and siderophore biosynthesis in Pseudomonas chlororaphis: implications for the biological control of cotton seedling disease pathogens
… synthesized by soilborne pseudomonads, siderophores (sid) (low molecular weight Fe⁺³ chelators) and antibiotics (ant), in the suppression of these pathogens. Greenhouse bioassays to screen for rhizosphere competent strains identified a single strain of Pseudomonas chlororaphis (L-850), …
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Generation of <i>Mycobacterium smegmatis</i> Model Systems for Testing Inhibitors of the Mycobactin Siderophore of <i>Mycobacterium tuberculosis</i>
… of iron scavenging molecules, known as siderophores (e.g., mycobactin and carboxymycobactin), has been identified as a potential drug target candidate since iron acquisition has been directly linked to the survival and virulence of <em>Mtb</em>. Salicyl-AMS (Sal-AMS) is an antibiotic …
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Characterization of the Genes Involved in Biosynthesis and Transport of Schizokinen, a Siderophore Produced by <em>Rhizobium leguminosarum</em> IARI 917.
… forms insoluble ferric oxyhydroxide polymers. Siderophores are low molecular weight compounds that scavenge ferric ions, bind with high affinity, and transport it into the cell via multicomponent transport systems. <em>Rhizobia</em> are soil dwelling organisms that form symbiotic relationships …
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Self-assembly of human defensin 6 and its role in innate immunity and siderophore-based strategies to target Gram-Negative bacteria
… the second part of this thesis, we present two siderophore-based strategies that target Gram-negative bacteria. Siderophores are small-molecule iron chelators that bacteria employ to sequester iron from the environment. Our approaches focus on enterobactin (Ent) and its glycosylated derivatives …
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Synthesis of staphyloferrin B (SB)-cargo conjugates
… combat bacterial infections involves the use of siderophore-drug conjugates to selectively deliver antibiotics to bacteria. Siderophores are low-molecular-weight chelators with high affinity for iron(Ill) that are biosynthesized by bacteria to acquire iron from the environment. Several reports of …
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