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Showing 1 to 20 of 21 for “"Shikimate"”.
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Designing high-performance yeast factories for the production of high-value aromatics based on a novel species and its consortia
… S. stipitis. Further introduction of a minimal shikimate-accumulating pathway resulted in the highest shikimate titer (4.5 g/L) and yield (90.5 mg/g sugar) ever reported in yeasts. Synthetic yeast consortia were developed for the production of precursors of benzyisoquinoline alkaloids by …
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SYNTHESIS OF NATURAL-DERIVED POLYPHENOLS AS POTENTIAL ANTICANCER AGENTS
… polyphenols, these latter directly derived from shikimate pathway, as phenylpropanoids and lignans, or from a mixed biosynthetic pathway (shikimate/ acetate and/or malonate pathways), as stilbenoids or flavonoids. My thesis is devoted to the family of polyphenols with the specific goal of …
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Isolation, Structure Elucidation, and Total Synthesis of Biologically Active Natural Products from Plants
… extract was investigated for inhibitors of the shikimate pathway in Plasmodium falciparum. Bioassay-guided fractionation of the extracts led to the identification of nineteen compounds with both antiplasmodial and antiproliferative activity, and thirteen compounds with only antiproliferative …
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Characterization of the Pathway Leading to the Synthesis of Salicylic Acid in Plants Resisting Pathogen Infection.
… levels. The results suggest that genes of the shikimate pathway are up-regulated in both plant lines but much more quickly in the resistant plant, making differential gene expression a possible cause of SA accumulation. Additionally, results showed a more pronounced decrease in amino acid …
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Comparative studies on the modes of action of SC-0224 and glyphosate
… effects of these herbicides on the conversion of shikimate to anthranilate in a cell-free extract of Klebsiella pneumoniae ATCC 25306 were also compared. SC-0224 and glyphosate equally inhibited the production of anthranilate indicating that SC-0224 has action similar to glyphosate on the …
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Biosynthetic Studies on Geldanamycin and Pactamycin
… units of geldanamycin and pactamycin via the shikimate pathway was studied. {('13)C(,6)}glucose was used to determine the incorporation of intact carbon units into both molecules. This revealed that the respective m-C(,7)N units were derived from three-carbon and four-carbon subunits …
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Phagosomal escape, sopravvivenza intracellulare e formazione di varianti di piccole colonie di Staphylococcus aureus USA300 nei macrofagi murini RAW 264.7
… mutazione senza senso nel gene aroK della via shikimate. L'analisi dell'espressione genica ha rivelato una significativa sovraregolazione di zur, mntR, uhpt, fur e sdrE nel SCV rispetto al BAA-1556 wild-type, probabilmente coinvolta nell'adattamento alla persistenza intracellulare, inclusa la …
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Evolution of gynodioecy and dioecy: theoretical issues and the case of Bidens sandvicensis and B. cervicata
… genotypes at the phosphglucoisomerase and shikimate dehydrogenase loci. Female frequencies at four population centers averaged 0.33, 0.27, 0.14,and 0.18 from 1989 to 1992, and 1989 measured out crossing rates at these centers were0.50, 0.55, 0.75 and 0.71. In Bidens sandvicensis, …
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An Investigation of Plant Hypersensitive Response and Photosynthesis Inhibition on a Genomic and Physiological Scale
… profiling of soybean in response to the shikimate pathway inhibitor, glyphosate, was analyzed and cross compared with that from HR and bentazon treatments. The gene expression profiling from HR and bentazon treatment shared similar patterns in many aspects, including the efforts to …
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Regional whole plant and molecular response of Kochia scoparia to glyphosate
… Whole plant glyphosate dose response and shikimate assays were used to confirm resistance and assess the level of resistance. Then PCR, quantitative PCR, sequencing, and immunoblotting techniques were used to determine the mechanism responsible for glyphosate resistance. Sequence of the …
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From the simple to the complex: an examination of different herbicide resistances
… a Pro106Ser substitution in the 5-enolypyruvyl-shikimate-3-phosphate synthase (EPSPS) gene]. Sequencing of the entire TennGR goosegrass EPSPS gene was performed and compared to that of the sensitive Tennessee population (TennGS). The results indicated that the population did contain the …
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Structural Biology of Cytochrome P450 Monooxygenases in Arabidopsis Thaliana Phenylpropanoid Pathway
… specificity of CYP98A3 for p-coumaroyl shikimate and indicated a possible substrate access channel. Procedures have also been developed for the expression of N-terminally truncated forms of CYP98A3 and CYP73A5 suitable for x-ray crystallography. Both proteins have been used in …
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Characterization of a novel five-way-resistant population of waterhemp (Amaranthus tuberculatus)
… acetolactate synthase (ALS), 5-enolpyruvyl-shikimate-3-phosphate (EPSPS), protoporphyrinogen oxidase (PPO), TIR1 auxin receptor, Photosystem II (PSII), and 4-hydroxyphenylpyruvate dioxygenase (HPPD). In 2012, a grower reported the failure to control a waterhemp population in conventional …
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Exploring Kinases of Metabolism and Signaling in the Malaria Parasite Plasmodium
… kinase 9 (PK9), protein kinase 5 (PK5), and shikimate kinase (SK) in Plasmodium with biochemical and chemical methods. </p><p>Specifically, target-based screening with the atypical P. falciparum PK9 revealed that benzimidazole and aminoquinoline compounds are able to bind the parasite kinase …
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Biochemical Characterization of Self-Sacrificing P-Aminobenzoate Synthases from Chlamydia Trachomatis and Nitrosomonas Europaea
… the canonical substrates, chorismate or other shikimate pathway intermediates. The gene product of ct610 was named Chlamydia Protein Associating with Death Domains (CADD) due to its established role in host mediated apoptosis, while the crystal structure showed an architecture similar to know …
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Constraints on plant resistance and tolerance trade-offs
… pathway involved in chemical defense, i.e., the shikimate pathway. Previous studies in the lab have shown that the process of endoreduplication is the primary mechanism by which plants compensate for lost tissue following mammalian herbivory (Scholes et al. 2011). Moreover, the gene G6PD1 was …
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Preemergence activity of chloroacetamide herbicides on a multiple herbicide-resistant population of waterhemp (amaranthus tuberculatus)
… synthase (ALS) inhibitors, 5-enolpyruvyl-shikimate-3-phosphate (EPSPS) inhibitors, protoporphyrinogen oxidase (PPO) inhibitors, synthetic auxins, Photosystem II inhibitors (PSII), and 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors. Chloroacetamide herbicides, however, have remained …
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Dynamic regulation of bacterial metabolic pathways using autonomous, pathway-independent control strategies
… the industrially-relevant intermediate, shikimate, resulting in an increase in titers from unmeasurable quantities to >100 mg/L. Finally, this QS device was coupled with a MI-biosensor circuit to institute two layers of dynamic regulation and further improve glucaric acid titers. …
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Identification of acyl transferases responsible for the diverse hydroxycinnamoyl chemical space in bidens pilosa
… transferase gene (HQT) and hydroxycinnamoyl-CoA: shikimate hydroxycinnamoyl transferase gene (HCT). Apart from the chlorogenic acids (quinic acid acyls), B. pilosa is known to also produce acyls of tartaric acid, also characterised by existence of structurally diverse isomers thereof. From other …
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