Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"SNAP25"”.
-
Estudio del papel de CSPa/DNAJC5 en la función y mantenimiento de las sinapsis glutamatérgicas del hipocampo en ratones adultos
… mantener la estabilidad de la proteína SNARE SNAP25. Esta cochaperona es esencial para el mantenimiento de sinapsis que operan en un régimen de alta actividad, pero los mecanismos moleculares de su acción protectora no están aún bien establecidos. Por otro lado, el funcionamiento de las …
-
Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
… granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). The aim of this thesis has been to investigate functional and genetic events that participate in the exocytotic process. First we show that SNAP25 is essential for cAMP-dependent …
-
Identification of novel palmitoyl acyl transferases and characterization of the role of Huntingtin palmitoylation in Huntington Disease
… palmitoylate other neuronal substrates such as SNAP25, PSD95 and GAD65. By contrast, mutant htt does not act this way, probably due to lack of interaction with HIP14. Furthermore, immunoprecipitated HIP14 from huntingtin+/- mice also exhibits less enzyme activity in palmitoylating GST-SNAP25 in …
-
Accelerated Ovarian Failure Causes Neuronal Detriments in the Menopausal Transition that are not Recovered by High Intensity Interval Training
… for neuronal and synaptic markers such as NeuN, SNAP25, PSD95 and BDNF. Mice that received VCD had lower discrimination index (%) on the NORT alongside lower SNAP25 and NeuN. Mice that received VCD in combination with exercise had no improvements in cognition, however, they had lower activity of …
-
The Impact of Calcium Binding Protein 5 (CaBP5) on Synaptic Vesicle Dynamics in Rod Bipolar Cells in the Retina
… synapses rely on SNARE complexes formed between SNAP25, synaptobrevin, and the retina-specific syntaxin isoform, syntaxin-3B. Syntaxin-3B can be phosphorylated at T14 via calcium/calmodulin dependent protein kinase II (CaMKII) in a calcium-dependent manner. Given its structural similarities to …
-
Investigating Pathogenic Mechanisms and Biomarkers in Alzheimer’s Disease
… marker synaptosomal-associated protein 25 (SNAP25). Overall, these results are relevant to our understanding of AD pathogenic mechanisms and disease biomarkers.
-
The use of lentivirus-mediated gene delivery to investigate the role of the Brain specific transcription factor MYT1L In-vitro and In-vivo
… stem cell differentiation: BCL11B, MYT1, SYN1, SNAP25 and JPH3. Further in-silico analysis localized a MYT1L binding site in the promoter region of each one of those genes, suggesting that they might be direct targets of MYT1L. In order to expand our understanding of the possible behavioural …
-
The Role of β-synuclein in the Pathological Mechanisms of Dementia with Lewy Bodies
… the frontal cortex and a decrease of VAMP2 and SNAP25 in the occipital cortex. Autophagy markers LC3-II and p62 were also increased in the frontal cortex where an increase in β-synuclein was identified in DLB brains and in vitro overexpression of β-synuclein attenuates the autophagy flux. …
-
A PROTEIN IN SEARCH OF FUNCTION: NIPSNAP1 IN MITOCHONDRIAL BRANCHED-CHAIN AMINO ACID METABOLON, BRAIN AND APOPTOSIS
… domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) belongs to a highly conserved family of proteins (NIPSNAPs 1-4) of unknown function and shows widespread tissue distribution. We have identified NIPSNAP1 in a protein complex (metabolon) that contains the …
-
Sex-Differences in Early-Onset Alzheimer's Disease
… In CN participants, women showed higher CSF SNAP25, whereas men showed a trend toward higher plasma pTau231. APOE ε4 status did not influence plasma or CSF biomarker levels in either sex. Conclusion: These analyses show that female sex and APOE ε4 status are associated with greater pathology …
-
Structure and Function of Proteins Involved in Regulated Secretion: Synaptotagmins and Complexin
… and the plasma membrane associated protein SNAP25. These proteins form a tight complex called the SNARE complex that is required for neurotransmitter release. This complex bridges the vesicle and plasma membranes, bringing them into close proximity. Formation of this complex is thus an …
-
Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
… expression of the exocytotic proteins STXBP1, SNAP25 and SYT11. In this paper I also made the novel observation that SYT11 increase basal insulin secretion and decrease rapid exocytosis, two phenomenons associated with T2D. The work on miR-335 emphasizes the importance of miRNAs in the …
-
Vitamin E : elucidation of the mechanism of side chain degradation and gene regulatory functions
… synaptobrevin, RAB3A, complexin 1, Snap25, ionotropic glutamate receptors (alpha 2 and zeta 1) were shown to be up-regulated in the supranutritional group compared to the deficient group. The up-regulation of synaptic genes shown in this work are not only supported by the strong …