Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 157 for “"SLE"”.
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Gene polymorphisms in SLE
Systemic lupus erythematosus (SLE) is an autoimmune disease, with a strong genetic component. It is characterised by hyperactive T and B cells, chronic inflammation and the production of antinuclear autoantibodies. SLE affects mostly women of child baring age, with a 9:1 ratio, women to men and has …
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Gut Microbiota Regulation of SLE Pathogenesis
Systemic Lupus Erythematosus (SLE) stands as a multifaceted autoimmune disorder, characterized by a spectrum of clinical manifestations and the generation of autoantibodies against self-antigens. Our focus was on the pivotal role of B cells in the development of SLE. The study also underscored the …
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On Existence and Convergence of SLE in Multiply Connected Domains
… theorems of the Komatu-Loewner equations for SLE in multiply connected domains. A now proof of the existence theorem for the chordal Komatu-Loewner equation, as an example of the general method, is also given. Next, this thesis discusses the convergence of bilateral SLE to radial SLE in …
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High prevalence of metabolic syndrome in patients with SLE in the Western Cape
… Patients with systemic lupus erythematosus (SLE) are at increased risk of the metabolic syndrome (MetS) and its complications. In the absence of published studies from sub-Saharan Africa, we investigated the prevalence and associations of the MetS amongst recent-onset SLE patients. METHODS: A …
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On the metric structure of random planar maps and SLE-decorated Liouville quantum gravity
… [square root of]8/3- LQG surfaces decorated by SLE8/3 and SLE6, respectively, with respect to a generalization of the Gromov-Hausdorff topology. We also introduce an approach for analyzing certain random planar maps belonging to the [gamma]-LQG universality class for general [gamma] E (0, 2) and …
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‘A Nothing Disease?’ An Interpretive Phenomenological exploration of the lived experience of Systemic Lupus Erythematosus (SLE)
… have a positive impact on the person living with SLE. These constraints indicate some of the priorities health services and organisations should be focusing on to assist those with lupus to regain a more homelike being-in-the-world. The findings have real implications for the development of health …
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Continuum Methods and Tightness Results for Non-Simple SLE and CLE: Existence, Interactions, and Metric Approximations
… in the theory of Schramm-Loewner Evolution (SLE) and Conformal Loop Ensembles (CLE), which are random fractal structures describing scaling limits of interfaces in two-dimensional statistical physics models. In particular, we deal with the construction and interaction of SLEκ curves and CLEκ …
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Hapten inhibition studies assessing the ability of a thymine derived hapten to bind DNA antibodies in sera from patients with systemic lupus erythematosus (SLE)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Identification of microRNA associated with systemic lupus erythematosus in Korean
BACKGROUNDS: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by polyclonal B-cell activation and elevated production of pathogenic autoantibodies. MicroRNAs (miRNAs) are short, noncoding RNAs that regulate gene expression on the post translational level, which can be …
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Significance of leptin and ghrelin in systemic lupus erythematosus in Koreans
… in patients with systemic lupus erythematosus (SLE), however there were no information about serum leptin and ghrelin level, antagonist hormone of leptin, in patients with SLE. We have evaluated the differences of serum leptin and ghrelin levels between patients with SLE and normal controls. …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder characterized by inflammation in several organ systems. SLE patients have an impaired ability to clear dying cells which leads to the exposure of several nuclear antigens which might break self tolerance. Autoantibodies directed …
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Predictors of hospital procedures completed for North Texas patients with systemic lupus erythematosus
… the diagnosis of systemic lupus erythematosus (SLE), indicated by an ICD-9-CM coding of 710.0. The secondary data obtained from the DFW Hospital Council for the years 1999 to 2005 was utilized to identify the most common procedures among patients hospitalized with SLE during a seven-year time …
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Neutrophil biomechanical properties and immune function in health and inflammatory disease
… psoriasis and systemic lupus erythematosus (SLE). Research completed at the National Institutes of Health (NIH) revealed that in the context of SLE, LDGs release higher levels of type 1 interferons, undergo increased NETosis, and accordingly drive inflammation. Meanwhile, advances in …
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Comparison of Supported Liquid Extraction and Solid Phase Extraction of Methamphetamine from Urine and Method Validation by Gas Chromatography-Mass Spectrometry
<p>Applications of SLE (supported liquid extraction) is a relatively new extraction technique that is not widely used in forensic toxicology. SLE is also easier and less time consuming than traditional LLE (liquid-liquid extraction) and SPE (Solid phase extraction). This work will compare the …
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Studies of Atherosclerosis in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of anti-nuclear autoantibodies, a wide spectrum of clinical signs, and a striking 9:1 female to male disparity in disease incidence attributed to the SLE disease promoting effects of estrogen. …
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Association and functional studies of genetic polymorphisms of MFGE8 gene in systemic lupus erythematosus
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by impaired clearance of apoptotic cells. Milk fat globule epidermal growth factor 8 (MFG-E8) is a protein connects between αvβ3 integrin of phagocytic macrophage and phosphatidylserine (PS) of apoptotic cell …
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Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nuclear antigens. Hyperactive B cells are present in SLE patients and murine models of lupus, many of which have defects in inhibitors of B cell receptor (BCR) signaling or plasma cell differentiation. …
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Beta2-microglobulin and antichromatin antibodies can be a disease activity markers in Systemic Lupus Erythematosus in Koreans
… in patients with systemic lupus erythematosus (SLE) and it has been suggested that their presence is associated with lupus disease activity. We have investigated the clinical significance of beta2-microglobulin and antichromatin antibodies in Korean SLE patients. MATERIALS AND METHODS: Blood …
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Studies on anti-dsDNA Antibodies and other potential biomarkers in Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation involving many organ systems. The etiology is unknown and the pathogenesis has not been fully elucidated. Impairments of the immune system and of the mechanisms regulating cell death are commonly seen in SLE patients. …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterised by immune complex deposition and production of autoantibodies against nuclear antigens (ANA). The aetiology of SLE is complex; however, twin and genome-wide association (GWA) studies clearly indicate that SLE …
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