Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"SIRT"”.
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Sedimentology, Diagenesis and Reservoir Characteristics of Eocene Carbonates Sirt Basin, Libya
… of Middle Eocene carbonates in the intracratonic Sirt Basin (at the northern margin of the African continent) is strongly influenced by depositional facies and various diagenetic modifications. This thesis investigates the petrography, sedimentology, diagenetic evolution and hydrocarbon potential …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… (PARP), cADP-ribose synthase (CD38) or SIRT inhibitors in HG/PA-induced cell death. Pharmacologic inhibitors of PARP such as 3-AB and INH2BP or reduction of PARP using siRNA did not protect HG/PA-induced viability reduction and HG/PA-induced DNA fragmentation. Knock down or …
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Three-Dimensional Morphology of Polymer Nanocomposites Characterized by Transmission Electron Tomography
… of MgO (cube-shape) generated by FBP, SART and SIRT tomographic algorithms under various reconstruction conditions, i.e. tilting range and increment. Examining the experimental data with known morphology permits quantitative determination of the accuracy of the reconstruction results by …
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Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage
… drives poly (ADP-ribose) polymerase (PARP) and sirtuin (SIRT) reactions, can be compromised and strategies for overcoming this limitation in the vasculature do not exist. This study determines if nicotinamide riboside (NR) delivery can augment NAD+ stores and fuel resistance to oxidative stress. …
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Study of the Metabolic Effects of Water-alcoholic Extracts of Heartwoods with Traditional Use in Bulgaria // Проучване метаболитните ефекти на водно-алкохолни екстракти от дървесини с традиционно приложение в България
… IL-lb, COX-2, iNOS, ICAM -1 and the increase of Sirt-1 mRNA levels for in LPS-stimulated macrophages. Based on the reported data we concluded that the Morus nigra heartwood infusion could be a potential source of active compounds with therapeutic potential in prevention and treatment of various …
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The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
… function of FOXO3. Resveratrol, an activator of SIRT deacetylase enzymes, inhibited these doxorubicin-induced PTMs and increased doxorubicin resistance. The expression of SIRT6, a known FOXO3 deacetylase, was also increased in TACE-resistant HCC tumors and correlated with cytosolic FOXO3. SIRT6 …
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Time-lapse Passive Seismic Velocity Tomography of Longwall Coal Mines: A Comparison of Methods
… simultaneous iterative reconstructive technique (SIRT), double difference least squares event relocation, and least squares event relocation. The three methods were compared and contrasted to determine if one is superior and if event relocation improves the image. Also, the tomograms were analyzed …
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Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
… polymerases (PARPs; e.g., PARP-1) or sirtuins (SIRTs; e.g., SIRT-1), which many of them are known to play an important role in gene regulation. In mammalian cells, NAD+ is synthesized from nicotinamide mononucleotide (NMN) and ATP, by the family of enzymes known as nicotinamide …
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Hydrocarbon Potential of Ne Libya (Cyrenaica): Sedimentology, Seismic Interpretation and Petroleum System Study
… productive sedimentary basins include the Sirt, Ghadamis, Murzuq, and Tripolitania basins that collectively contain the country’s major 320 producing oil fields whose reserves exceed 44 billion barrels of recoverable oil and 37 trillion cubic feet of gas. Hydrocarbons in these basins and …
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The Role of Sirtuin Inhibitors on the Proteomic Responses of the Mussels Mytilus galloprovincialis and Mytilus trossulus to Menadione Induced Oxidative Stress
… detoxify ROS. Additionally, we hypothesize that sirtuins (SIRT; a family of NAD-dependent deacetylases) might be involved in the regulation of this metabolic transition. To test the latter, a discovery approach will be used to analyze the proteomic response of <em>M. galloprovincialis </em>and …
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An integrated geophysical study of the Ionian Basin western margin : new insights on its Permo-Triassic origin
… crustal density from the Pelagian Shelf and the Sirt Rise towards the Ionian Basin. The crustal thickness is in agreement with published results from deep-penetrating seismic surveys. Moreover, the relatively high density of the crust of the Shelf suggests that it is made up of oceanic accretions …
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Global Relationships Between Intraplate Magmatism and Dynamic Topography
… to exist beneath the western edge of the Sirt Basin, Libya. Anatolian topography is charaterised by high elevation, low relief plateaux. Miocene marine sedimentary deposits occur at elevations of ~1 km which indicates that this region has experienced significant youthful uplift. A …
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Tomographic Imaging Associated with a Mw 2.6 Fault-Slip Event in a Deep Nickel Mine
One of the biggest challenges facing geoscientists is the ability to accurately predict failure within a rock mass. Conventionally, numerical modeling is performed to predict the response of the rock mass due to excavation. However, numerical modeling relies heavily on the estimated physical …
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The Role of Resveratrol and Sirtuin1 in Skeletal Muscle Under a Nutrient Stress
… and myotubes. Interestingly, the activation of Sirtuin1 (SIRT1) has been reported during DR and its reduction abrogates lifespan extension. Importantly, SIRT1 activation via resveratrol treatment has been indicated to be important in the presence of inflammatory stress (TNF-α) (Saini et al., …
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Heat stress: A risk factor for skin carcinogenesis
… heat stress has been linked with increased Sirtuin1 (SIRT1) protein activity. SIRT1 is an important histone deacetylase that helps maintain chromosomal integrity but can also induce post-translational modifications of the p53 protein. By mediating deacetylation of the p53 protein, SIRT1 can …