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Showing 1 to 20 of 21 for “"SERM"”.

  1. Proteomic Investigation of Endocrine Therapy Resistance in Breast Cancer Investigating the Molecular Mechanisms for SERM Resistant Cell Lines Using SILAC-Based Proteomic Approach

    Al-Kabariti, Aya Y.University of Bradford2022

    … resistant cell lines independent of phenotype or SERM. Overall, the results provided interesting targets for re-sensitising resistant breast cancer and the potential to investigate novel combination therapies in the future.

    bradford Repository record

  2. Tamoxifen metabolites can target both aromatase and estrogen receptors

    Liu, Jinzhong2015

    … classes: selective estrogen receptor modulators (SERMs), selective estrogen receptor down-regulators (SERDs) and aromatase inhibitors (AIs). However, the efficacy and safety of SERMs, SERDs and AIs are compromised by side effects or tumor resistance. One possible way of improving treatment …

    iupui Repository record

  3. Effekte von Östradiol, Equol, Cimicifuga racemosa und Metformin im Serum und auf die Histomorphologie im Uterus der ovarektomierten Ratte

    Schebb, Frauke2012

    … Östrogenrezeptormodulator-Eigenschaften (SERM) haben und selektiv östrogenagonistische Effekte am Knochen, ZNS, Vagina und Herzkreislaufsystem besitzen und gleichzeitig östrogenantagonistische Wirkungen an Mamma und Uterus ausüben. Gegenstand dieser Arbeit war es die Wirkung der …

    goettingen Repository record

  4. Development of Combinatorial Approaches Towards Selective Estrogen Receptor Modulators: Investigations of Acyclic Amides and Tetra-Substituted Pyrazoles

    Stauffer, Shaun RobertUniversity of Illinois at Urbana-Champaign2015

    … illustrates the first efforts towards a novel SERM containing a pyrazole scaffold as its core structure.

    uiuc Repository record

  5. Estrogen Receptor Ligands and Regulation of Gene Expression

    Sheng, ShubinUniversity of Illinois at Urbana-Champaign2015

    … and the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene. KRT13 is a cytoskeleton protein while CALCR mediates the biological effects of calcitonin. These two genes may play important roles in breast cancer growth and metastasis. Analysis of the promoters and regulatory …

    uiuc Repository record

  6. Pharmakologische Untersuchungen zu endokrinen Effekten des UV-Filters Ethylhexyl-methoxycinnamat

    Klammer, Holger2012

    … selective estrogen receptor modulator (SERM)-Effekte sowie nicht Estrogen-ähnliche bzw. nicht Estrogenrezeptor (ER)-vermittelte Effekte. Deshalb wurde die endokrine Aktivität in vivo in einem erweiterten uterotrophen Assay untersucht. Dazu wurde der Fokus von einem einzelnen Organ bzw. …

    goettingen Repository record

  7. I. A Structure-Based Approach Toward the Development of a Ligand-Receptor System With Unique Specificity. II. Synthesis and Evaluation of Hexahydrochrysene and Tetrahydrobenzofluorene Derivatives as Selective Estrogen Receptor Modulators

    Tedesco, RosannaUniversity of Illinois at Urbana-Champaign2015

    … termed selective estrogen receptor modulators (SERMs), are better candidates for applications in the treatment of estrogen sensitive breast cancer and pathologies associated with postmenopausal conditions. The basis of SERMs tissue selectivity is not clear, and possibly due to different …

    uiuc Repository record

  8. Estrogen Inducible Proteinase Inhibitor 9 Protects Target Cells From Immune Surveillance and Apoptosis

    Cunningham, Thomas D.University of Illinois at Urbana-Champaign2015

    … of the selective estrogen receptor modulator (SERM), 4-hydroxytamoxifen (OHT) (the active metabolite of tamoxifen), we used a tet-inducible MCF-7 cell model system, termed MCF7ERalphaHA cells. In MCF7ERalphaHA cells, OHT is a full agonist and induces higher levels of PI-9 than E2. In …

    uiuc Repository record

  9. Thermoneutral Housing Did Not Impact the Combined Effects of External Loading and Raloxifene on Bone Morphology and Mechanical Properties in Growing Female Mice

    Tastad, Carli A.2020

    … selective estrogen receptor modulator (SERM) that improves tissue quality by binding to collagen and increasing the bound water content in the bone matrix in a cell-independent manner. In this thesis, active tissue formation was induced by non-invasive external tibial loading in female …

    iupui Repository record

  10. Östrogenes Potential des endokrinen Disruptors 4-MBC im Reproduktionstrakt von ovariektomierten Ratten

    Hilgendorf, Leonie2012

    … ERα-Expression. Zusammengefasst könnte dies eine SERM-Eigenschaft des 4-MBC aufzeigen. Die Ergebnisse weisen Uterus und Hypophyse als sehr empfindliche Organe gegenüber einer xenoöstrogenen Beeinflussung durch 4-MBC aus. Da auch bei der niedrigsten getesteten Dosierung ein Einfluss nachweisbar …

    goettingen Repository record

  11. Regulation of estrogen receptor-alpha mediated gene expression and endocrine resistance through estrogen receptor-alpha phosphorylation and micro-RNA in breast cancer

    Kim, KyuriUniversity of Illinois at Urbana-Champaign2011

    … of selective estrogen receptor modulators (SERMs) and selective estrogen receptor downregulators (SERDs), the regulation of ER transcriptional activity, and stimulation of cell proliferation in response to estradiol and SERMs/SERD. We showed that changes in ER affecting the phosphorylation …

    uiuc Repository record

  12. Interactive Effects of Bazedoxifene acetate and Conjugated Equine Estrogens on the Breast and Reproductive Tract of Postmenopausal Monkeys

    Ethun, KellyWake Forest University2012

    … selective estrogen receptor modulator (SERM) currently under investigation as a possible choice for this role. The primary objective of this project was to determine if BZA given at the clinical target dose of 20 mg/day would inhibit the proliferative effects of CEE (0.45 mg/day) on the …

    wfu Repository record

  13. Interplay Between Estrogen Response Element Sequences and Ligands Controls Binding of Estrogen Receptor to Regulated Genes

    Krieg, Adam JeremyUniversity of Illinois at Urbana-Champaign2015

    … the pure antiestrogen ICI 182,780 nor the SERM Raloxifene activates either PI-9 or pS2. Surprisingly, ICI-liganded ER behaves more like OHT-liganded ER on PI-9 and pS2, while Raloxifene-liganded ER behaves more like Moxestrol-liganded ER. Based on these combined data, I propose that the …

    uiuc Repository record

  14. Vergleichende molekulare und physiologische Untersuchung von Östradiol, drei Flavanonen und eines Heilpflanzenextrakts auf Östrogen-regulierte Endpunkte in Uterus und Gefäßsystem

    Kretzschmar, GeorgTechnische Universität Dresden

    … als selektiver Östrogenrezeptor-Modulator (SERM) und zeigt für einen Einsatz in der HRT sehr interessante Eigenschaften, da weder ein uterotrophe Wirkung in vivo, noch eine angiogene Wirkung in vitro beobachtet werden konnte, während gleichzeitig eine östrogene, potentiell kardioprotektive …

    qucosa-diss

  15. The mechanism of tamoxifen action on glioma cell lines

    Cantrill, CarinaUniversity of Central Lancashire2007

    … of the selective estrogen receptor modulator (SERM) family, is widely used in the treatment of estrogen-receptor (ER) positive breast cancer. It has been shown in previous studies that Tamoxifen exerts an antiproliferative effect in patients harbouring glioma. Glioma brain tumours differ from …

    cent-lancashire Repository record

  16. Einfluss von Estradiol, Genistein, Equol und Resveratrol auf verschiedene östrogensensitive Organe und Parameter der ovariektomierten Maus

    Mählmeyer, Sandra2012

    … des Interesses gerückt, da sie als potentielle SERMs imponieren. Um diese Hypothese zu überprüfen, wurden in den letzten Jahrzehnten multiple Studien zur anti-/östrogenen Wirkung verschiedenster Substanzen am, seit 2001 von der OECD validierten, Modell der ovariektomierten Ratte durchgeführt. In …

    goettingen Repository record

  17. Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms

    Fang, ZijianUniversity of Cambridge2023

    … The selective oestrogen receptor modulator (SERM) tamoxifen (broadly used in ER+ breast cancer) was effective on eradiating JAK2<sup>V617F+</sup> haematopoietic stem and progenitor cells (HSPCs) in preclinical mouse MPN models, which prompted a Phase-II clinical study (Effects of TAMoxifen on …

    cambridge Repository record

  18. Localisation of sex steroid receptors and effect of Tamoxifen upon glioma cell lines in vitro

    Liappas, Alexandros IoannisUniversity of Central Lancashire2007

    … of the selective estrogen receptor modulator (SERM) family, is widely used in the treatment of estrogen receptor (ER)-expressing breast cancer. It has been shown that a high dose of Tamoxifen has cytotoxic activity against gliomas, but whether this effect is drug specific or represents a …

    cent-lancashire Repository record

  19. IMMUNOMODULATORY ACTIVITY OF TAMOXIFEN AND RALOXIFENE IN MACROPHAGES: IMPLICATIONS FOR HOST-DIRECTED THERAPIES IN INFECTIOUS DISEASES

    SFOGLIARINI, CHIARAUniversità degli Studi di Milano2026

    … selettivi del recettore degli estrogeni (SERMs), ampiamente prescritti per il trattamento di patologie dipendenti dal recettore degli estrogeni α (ERα), come il tumore al seno ERα-positivo e l’osteoporosi. Recentemente, questi farmaci hanno suscitato interesse per la loro inaspettata …

    milano Repository record

  20. Identification and characterization of estrogen receptor-regulated gene expression programs

    Barnett, Daniel H.University of Illinois at Urbana-Champaign2010

    Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2012-05-15T10:00:18Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Dissertations and Theses - Cell and Developmental Biology (ID: 702) No. of bitstreams: 4 Barnett_Daniel.pdf: 1415172 bytes, checksum: …

    uiuc Repository record

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