Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"SASP"”.
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Regulation and inhibition of pro-tumorigenic microenvironments
… the senescence-associated secretory phenotype (SASP). The SASP is composed of pro-angiogenic, pro-inflammatory, pro-growth and extracellular matrix remodeling proteins. Through the SASP, senescent cells promote all stages of tumorigenesis. Interestingly, senescent fibroblasts accumulate in human …
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Úloha cytokinů v podpoře maligních vlastností glioblastomů
… senescence-associated secretory phenotype (SASP). The SASP is distinct in its secretion of growth factors, components of the extracellular matrix and remodelling enzymes, but above all proinflammatory cytokines, which may contribute to the malignant properties of GB. This thesis reviews the …
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Senescence Associated Secretory Phenotype Regulation in Lung Aging and Malignancy Progression
… the senescence-associated secretory phenotype (SASP). Although secreted factors are known to have important biological effects on both senescent and non-senescent cells in the contexts of normal aging and disease, the precise molecular mechanisms responsible for generating a SASP in response to …
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THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS
… fenotipo secretorio associato alla senescenza (SASP). Nonostante la crescente consapevolezza del ruolo dannoso delle VSMC senescenti nell'aterosclerosi—come infiammazione cronica locale, degradazione della matrice extracellulare e rimodellamento tissutale—il loro possibile contributo …
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The role of High Mobility Group A1 protein in transcriptional regulation of cellular senescence
… senescence-associated secretory phenotype (SASP). These molecules can be beneficial or detrimental depending on the biological context. High mobility group A (HMGA) proteins are DNA binding proteins that are known to be highly expressed in embryonic, senescent and cancer cells. HMGA1 is a …
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The Function and Regulation of Senescent Stromal-Derived Osteopontin
… of the senescence-associated secretory profile: SASP). I demonstrate that SASP is coordinately upregulated in response to multiple stimuli inducing senescence namely DNA damage, chromatin modulation and ectopic expression of p27, a cyclin-dependent kinase inhibitor. However, my work on the …
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Effect of Estradiol on xc- in Human Breast Cancer Cells
… oxidative stress. The drug sulfasalazine (SASP) has been shown to specifically inhibit this system leading to cell stasis and glutathione depletion. Using the ER positive human breast cancer cell line MCF-7, the xc- specific subunit, xCT, mRNA and protein expression were found to decrease …
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Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis
… of senescence-associated secretory phenotype (SASP) factors. PMS-derived iNSCs exhibited elevated synthesis of fatty acids and cholesterol, leading to the accumulation of cholesteryl ester-enriched lipid droplets. Furthermore, the lipogenic state mediated by HMG-CoA reductase activity triggered …
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Premature vascular senescence during diabetic retinopathy
… the senescence-associated secretory phenotype (SASP) and triggered by mechanisms such as telomere shortening and DNA damage. Diabetes is associated with endothelial dysfunction, which is characterised by increased vascular permeability, deficit in blood perfusion, vessel loss and increased …
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Die Untersuchung zellulärer inflammatorischer Prozesse bei Pseudoxanthoma elasticum
… of a senescence-associated-secretory phenotype (SASP), was detected. The SASP is associated with high production of inflammatory factors, such as interleukin 6. The molecular mechanism leading to inflammatory processes in PXE are not fully understood. Thus, this study was designed to analyze …
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Inmunolocalización de la sustancia P y del receptor NK-1R en el craneofaringioma adamantinomatoso
… de Fenotipo Secretor Asociado a Senescencia (SASP) donde se emiten sustancias paracrinas que establecen un microambiente tumoral invasor. La Sustancia P (SP) y el receptor de Neurokinina 1 (NK- 1R) han sido descritos como potenciadores del efecto oncogénico y el bloqueo de NK-1R como un …
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Molecular and phylogenetic analysis of a Bacillus thuringiensis genetic locus
… small, acid soluble protein (SASP) gene was also discovered. This gene, which may be plasmid encoded, showed considerable sequence similarity to $\alpha$/$\beta$-type SASP from $\textit{Bacillus megaterium}$. The discovery of this gene raises new questions about taxonomic …
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B-RafV600E에 의한 갑상샘 발암과정에서 Thyroid stimulating hormone (TSH) 의 역할연구
… 7. B-RafV600E-induced senescent cells expressed SASP especially MMPs. 48 8. Cell invasion was dependent on OIS. 53 9. Cells with a senescent phenotype were found in regional LNs and the lymphatic channel. 55 10. Senescent cells mediate cancer cell invasion by means of the CXCR4 and CXCL12 …
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Autonomous and non-autonomous regulation of chromatin structure during cellular senescence
… the senescence-associated secretory phenotype (SASP), we have recently identified that NOTCH1 can drive a unique form of senescence in adjacent cells via juxtacrine signalling. Here, we show that NOTCH1 signalling confers a dramatic impact on chromatin structure during senescence. RAS-induced …
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How does who we are affect what we do : an exploration of the organizational identity-strategy nexus in a UK based megachurch
… the concept of Strategy-as-Spiritual Practice (SaSP), which highlights how spiritual beliefs filter strategic information and shape actions, decentering rational cognitive tools in favour of divine guidance. Using a single case study approach enabled by privileged access, the research draws on …
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Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
… the senescence-associated secretory phenotype (SASP), which can conversely have a pro-tumorigenic impact on the cellular microenvironment. Yet, aberrant oncogene activation alone is insufficient for triggering OIS, as studies both in vitro and in vivo have demonstrated that low-dose oncogene …
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Relevanz der humanen Xylosyltransferase-I in der Seneszenz-assoziierten Gewebe-Remodellierung und der adulten Knochenhomöostase
… a senescence-associated secretory phenotype (SASP)-mediated induction of XT-I gene expression and activity along with an expression increase of ECM-associated proteins was determined for the first time after hCSCs were cultured with conditioned media of transforming growth factor-β1 (TGF-β1)- …
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Novel Proteases That Regulate Interleukin-1 Alpha Activity During Inflammation And Senescence
… the senescence-associated secretory phenotype (SASP), which drives the deleterious effects of senescent cells in multiple age-related diseases. Therefore, therapeutically targeting caspase-5 may be of interest for pathologies mediated by the non-canonical inflammasome and/or senescent cells. …
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Macrophage Response to Interleukin-1 Stimulation and the Nature of Cell Surface Interleukin-1 Alpha
… the senescence-associated secretory phenotype (SASP). We show that pro-IL-1α is synthesised de novo and trafficked to the membrane following TLR4 stimulation. We report two novel ways by which csIL-1α can be bound, through the type II IL-1 receptor (IL-1R2) and glycosylphosphatidylinositol (GPI) …
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MMP-7 nanosensors for urine-based detection of chemotherapy-induced senescence and pulmonary fibrosis
… of senescence-associated secretory phenotype (SASP). Senescence is considered a fundamental tumour suppression mechanism to prevent the expansion of oncogenically-stressed premalignant cells, including in lung cancer. When senescent cells accumulate in tissues, however, they can also play a …
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