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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Runx2"”.
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Runx2 and Vascular Calcification
… and occlusive lesions in the vasculature. Runx2 (runt-related transcription factor 2) is a critical regulator of bone development, early chondrocyte proliferation, and hypertrophic chondrocyte formation. Surprisingly, Runx2 has been found to be upregulated in arteries of patients with …
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Die Untersuchung des Transkriptionsfaktors RUNX2, insbesondere die RUNX2-Cbfß Interaktion in der Pathogenese der cleidocranialen Dysplasie
RUNX2, auch als CBFA1, OSF2 und AML-3 bezeichnet, ist ein für die Knochenentwicklung essentieller Transkriptionsfaktor. Mäuse, die einen homozygoten Defekt des RUNX2 Gens aufweisen (Runx-/-), zeigen einen vollständigen Block in der Osteoblastendifferenzierung und damit der Knochenentwicklung. Mäuse …
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Role of the RUNX2 rs59983488 variant in bone mass determination and fracture risk in Malta
… risk. The Runt-related Transcription Factor 2 (RUNX2) protein encoded by the RUNX2 gene is involved in the maturation and differentiation of osteoblasts and chondrocytes that are, crucial for endochondral bone formation. The RUNX2 rs59983488 (G>T) variant, located -330bp from the transcriptional …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
… the role of runt related transcription factor-2 (Runx2) in peripheral nerve regeneration. While the published literature and my in-silico analysis showed significant upregulation of Runx2 in Schwann cells following peripheral nerve injury, Runx2 has no previously established role in peripheral …
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RUNX2 promueve la angiogénesis y la expresión de genes blanco con función pro-angiogénica en osteosarcoma
Runx2 es un factor transcripcional, regulador maestro del desarrollo y de la diferenciación osteoblástica. Regula positiva o negativamente la expresión de diversos genes que participan en la proliferación de precursores pre-osteoblásticos y osteoblásticos, y en la diferenciación de estos. Además, …
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Isolierung, Sequenzierung und Charakterisierung der genomischen Region von Frunx2, dem Fugu-rubripes-Ortholog des humanen RUNX2-Gens
… 105 kb lange Sequenz des genomischen Lokus von Frunx2, einem hier identifizierten und charakterierten Fugu-Ortholog des humanen RUNX2-Gens untersucht. Sowohl die Aminosäuresequenz als auch die genomische Organisation von Frunx2 sind in hohem Maße identisch mit der des humanen RUNX2, insbesondere …
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Multiple Conserved Enhancers of the Osteoblast Master Transcription Factor, Runx2, Integrate Diverse Signaling Pathways to Direct Expression to Developing Bone
… pathway regulated by the transcription factor Runx2. Runx2 is required for bone formation, and haploinsufficiency in humans causes the skeletal syndrome cleidocranial dysplasia, demonstrating the importance of gene dosage. Despite the central role of Runx2 in directing bone formation, little is …
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Role of Amplification of Chromosome 6P12-P21 in Human Osteosarcoma
… of the osteogenic transcription factor gene RUNX2, and measures of CIN as well as tumour response to chemotherapy in a retrospective cohort of osteosarcoma patients. The present study demonstrates: 1) Gain and amplification events involving chromosome 6p12-p21 have been frequently reported in …
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The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… through runt-related transcription factor2 (Runx2) expression and transcriptional activity, transcriptional coactivator with PDZ-binding motif (TAZ), OC expression and mineral nodule formation. Poncirin prevented adipocyte differentiation via inhibition of lipid droplet accumulation, PPAR-γ, …
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Molecular Regulation of Vascular Calcification In Murine Models of Atherosclerosis
… reduced the levels of osteogenic genes (e.g. Runx2, BMP-2 and ALP) as well as calcification in ApoE-/- VSMCs exposed to elevated inorganic phosphate (Pi). The genetically modified VSMCs isolated from ApoE-/- mice displayed inceased activation of the canonical Wnt/β-catenin pathway at the …
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Effects of acetylsalicylic acid on odontogenesis of human dental pulp cells and TGF-ß1 liberation from dentin
… the fluorometric assay. Expressions of DSP and RUNX2 were determined with ELISA. DSP and RUNX2 mRNA levels were measured with RT‐qPCR. Alizarin red staining was conducted to evaluate the mineralized nodule formation. Dentin slices were submerged in PBS (negative control), 17% EDTA (positive …
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Differential expression and phenotypic activities of osterix in equine mesenchymal stem cell populations
… factors, runt-related transcription factor 2 (RUNX2) and Osterix (OSX), with interplay from signaling pathways such as the Bone Morphogenetic Protein (BMP) network. MSCs isolated from bone marrow (BM) and adipose tissue (ADI) are most commonly utilized in human and veterinary regenerative …
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Developing Novel Approaches to Improve Response to T Cell Based Cancer Immunotherapy
… Amongst them, was the transcription factors Runx2, a gene whose role has not been described in T cells, to be one of the genes that were differentially expressed. In addition, we found that when Runx2 was absent in T cells they did a better job at controlling tumour growth and vice versa. …
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The role of p53 in virus-induced and multi-step lymphomagenesis
… used; a cohort of MMLV-infected mice and also a Runx2/Myc surrogate model which develop tumours after a significantly reduced latent period. The data suggested that whilst p53 loss is obligatory for in vitro culture of tumour cells, it is not required for the growth of tumours passaged in vivo. …
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… matrix stiffness promoted increased nuclear RUNX2 levels, increased DDR1 activation and expression, increased Vav2-RhoA activity, and increased stress fibre formation in Ddr1+/+ but not Ddr1-/- VSMCs. RhoA activation increased DDR1 expression and activity independent of ligand, whereas …
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THE ROLE OF ENDOTHELIAL CELLS IN VASCULAR CALCIFICATION
… induces osteoblastic differentiation with RUNX2 and BMP2 mRNA up-regulation up to day 7, osteopontin increased protein expression and positive Alcian Blu staining. In calcified ECs mesenchymal and endothelial markers, such as α-SMA, SM22α, FSP-1 and Fibronectin or vWF progressively …
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The Effect of Lycii Radicis Cortex Extract on Bone Formation in vitro and in vivo
… expression of bone metabolic markers Alpl, Runx2, and Bglap genes in both cell lines. There was no effect on the osteoclastic differentiation of primary-cultured monocytes from the mouse bone marrows. Furthermore, the effect of LRC extract in vivo was examined in ovariectomized (OVX) mice. …
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The roles of Rb, p107, and E2f4 in bone formation and embryonic development
… of pro-osteoblastic genes, including Bmp2, Msx2, Runx2 and Osterix. By using the same strategy to conditionally delete Rb in p107/- embryos, we observe lethality at approximately e14.5 during development.
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SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
… and increases the transactivation potential of Runx2. In osteoclasts, SirT1 inhibits differentiation largely through repression of the p65/RelA subunit of NF[kappa]B. Finally, we show that calorie restriction (CR) results in increased bone mass that is associated with higher osteoblast and lower …
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Etablierung einer Zellkultur von PDL-Fibroblasten aus parodontal erkranktem Zahnhalteapparat des Menschen
… eine Herunterregulation von Kollagen Typ I und Runx2 im Vergleich zu gesunden PDL-Zellen. Eine unveränderte Expression stellt sich für CD13 und CD73 als Faktoren, welche die Immunantwort modulieren, und für CD44 und CD29 als Adhäsionsmoleküle dar. Die statistische Auswertung der FACS-Ergebnisse …
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