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Showing 1 to 20 of 176 for “"Ribose"”.

  1. Ribose nucleic acid and the cell nucleus

    Roy, Alexander B.The University of Edinburgh1949

    1. Methods of estimation of ribose nucleic acid are discussed and a reliable method for the estimation of that substance in isolated cell nuclei described.

    edinburgh Repository record

  2. Ribose-5-Phosphate Degradation in Microbacterium Lacticum

    Krichevsky, Micah IsaacUniversity of Illinois at Urbana-Champaign2014

    Made available in DSpace on 2014-12-05T23:07:53Z (GMT). No. of bitstreams: 1 5900535.pdf: 4094040 bytes, checksum: 7ee41e468353def5f6b25488194dbc8f (MD5) Previous issue date: 1958

    uiuc Repository record

  3. Enzymatic synthesis of defined-length poly(ADP-ribose) and the investigation of cell-permeable poly(ADP-ribose) glycohydrolase inhibitors

    Yang, WoojinUniversity of Illinois at Urbana-Champaign2016

    … cancer cells. To this end, various Poly(ADP-ribose) Polymerase (PARP) inhibitors have been developed to induce sensitivity to genotoxic stress in BRCA-mutated cancer cells, and Poly(ADP-ribose) Glycohydrolase (PARG) inhibition is investigated as an alternate pathway to PARP inhibition in …

    uiuc Repository record

  4. Learning the ABC's of Ribose Transport Using Biophysical Methods

    Erramilli, Satchal K

    … understanding the motor protein of the bacterial ribose ABC transporter in the context of transport. This complex is required for the uptake of the nucleotide precursor, ribose. Using biophysical methods, we seek to better understand the protein conformational changes and dynamics that link ATP …

    purdue-thes Repository record

  5. Purification and Properties of Poly (Adenosine Diphosphate Ribose) Synthetase

    Okayama, HirotoKyoto University1978

    kyoto Repository record

  6. The chemical and enzymatic synthesis of poly(ADP-ribose)

    Lambrecht, MichaelUniversity of Illinois at Urbana-Champaign2016

    Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are …

    uiuc Repository record

  7. Production of furfuraldehyde from d-lyxose and d-ribose

    Guttag, AlvinMassachusetts Institute of Technology1940

    Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1940.

    mit Repository record

  8. Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization

    Pater, JustinUniversity of Saskatchewan2013

    … adapter protein. Nuclear enzyme Poly ADP-ribose Polymerase-1 (PARP-1) and the transcriptional repressor Snail-1 work with ILK to downregulate epithelial cell-cell adhesion. This process would also be necessary for proper trophoblast syncytialization. Thus, it was hypothesized that PARP-1 …

    sask Repository record

  9. DEVELOPING SMALL-MOLECULE PROBES AND INHIBITORS FOR ADP-RIBOSE-BINDING PROTEINS

    Peng, KewenCornell University2025

    … drug development for two classes of ADP-ribose-binding proteins has been lacking. The first one is viral macrodomains (Mac), which can bind and hydrolyze host cell protein MARylation induced by interferon (IFN) signaling and thus counter host immune response. Although several …

    cornell Repository record

  10. Structure and function of the human Poly(ADP-ribose) polymerase enzyme family

    Rood, Jennifer E. (Jennifer Evelyn)Massachusetts Institute of Technology2013

    The poly(ADP-ribose) polymerase (PARP) family of enzymes in humans is comprised of 17 proteins. PARP-1, the first member of the family, synthesizes a large, complex post-translational modification, poly(ADP-ribose). While PARP-1 and some other PARPs have been extensively functionally characterized, …

    mit Repository record

  11. A reverse genetics study of the Human Coronavirus 229E ADP-ribose-1"-phosphatase

    Dammann, SabineQueen's University Belfast2011

    … a conserved nsp3 domain called ADRP (ADP-ribose -1”-phosphatase) was investigated using a reverse genetics approach. To better understand the role of the ADRP in viral replication, a set of HCoV-229E ADRP mutants was generated, including viruses with a (i) mutation in the putative ADRP …

    qu-belfast Repository record

  12. Development of poly(ADP-ribose) glycohydrolase inhibitors and tetracyclic indoles as anticancer compounds

    Knezevic, ClaireUniversity of Illinois at Urbana-Champaign2014

    … is the target-based development of poly(ADP-ribose) glycohydrolase (PARG) inhibitors as putative anticancer compounds as well as the discovery of a class of potent anticancer tetracyclic indoles through a phenotypic screen. PARG plays a crucial role in DNA damage repair, and lack of PARG …

    uiuc Repository record

  13. The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death

    Finch, Kristin E.University of Illinois at Urbana-Champaign2011

    … of single strand DNA breaks by the poly(ADP-ribose) (PAR) cycle, which is an enzymatic cycle that promotes DNA repair after mild DNA damage. In contrast, upon severe DNA damage, the PAR cycle is known to promote acute cell death, which can result in ischemia or neurological diseases. …

    uiuc Repository record

  14. Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family

    Vyas, Sejal (Sejal Kamlesh)Massachusetts Institute of Technology2014

    The poly(ADP-ribose) polymerase (PARP) protein family consists of seventeen enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs in the nucleus, such as in DNA damage repair and transcriptional regulation, …

    mit Repository record

  15. Poly (Adp) Ribose Polymerase Inhibitors For The Treatment of Malignant Peripheral Nerve Sheath Tumor

    Kivlin, Christine M2016

    … the outcome for MPNST patients. Poly (ADP) ribose polymerase (PARP) inhibitors were first reported over a decade ago to have substantial anti-tumorigenic effects in malignancies with defective DNA repair, specifically those with <em>BRCA1/2</em> (breast cancer, early onset 1/2)<em> …

    uthsc Repository record

  16. Functional characterization of poly(ADP-ribose) dependent ubiquitin E3 ligase in the DNA damage response

    김, 재진2016

    Ⅰ. INTRODUCTION 1 A. DNA damage response 1 B. DNA damage repair 3 1. Homologous recombination (HR) 4 2. Nonhomologous end joining (NHEJ) 5 C. Ubiquitylation mediated DNA damage response signaling 6 1. Ubiquitylation 6 2. Post-translational modification mediated DNA damage response 7 3. RNF4 …

    ajou Repository record

  17. A Solid State NMR Investigation of Poly (ADP-ribose) and Its Involvement in Tissue Calcification

    Murgoci, AdrianUniversity of Cambridge2022

    … The Duer group discovered that poly (ADP-ribose) (PAR), a biological polymer produced in response to DNA damage, is deposited in the calcified matrix of bone and pathologically mineralised arteries and could play an important role in mineralisation. PAR has affinity for calcium, forming …

    cambridge Repository record

  18. Production of poly(adenosine diphosphate-ribose) polymerase-1: development of an efficient production and purification protocol

    Knight, MatthewVictoria University of Technology2003

    PARP-1 is a nuclear enzyme involved in a range of activities associated with DNA metabolism, playing a key role in maintaining the integrity of DNA and chromatin structure. As such, this enzyme is likely to provide a useful target when using a rationale drug design approach to develop …

    vu-aus Repository record

  19. Untersuchungen zur Inhibierung der Expression der Poly(ADP-ribose)Polymerase (PARP) nach Infektion mit Toxoplasma gondii

    Gais, Andrea Nadja2012

    … auch die Inhibierung der Expression der Poly(ADP-Ribose) Polymerase (PARP)-1. PARP-1 ist ein nukleäres Protein und spielt eine wichtige Rolle in verschiedenen zellulären Abläufen einschließlich DNA Reparatur, Apoptose, Nekrose und Regulation der Genexpression. Außerdem ist es an der Pathogenese …

    goettingen Repository record

  20. Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target

    Botta, DavideThe University of Arizona.2010

    … regulated by the synthesizing enzymes poly(ADP-ribose) polymerases (PARPs) and the degrading enzyme poly(ADP-ribose) glycohydrolase (PARG). PARP-1, the first-discovered and major PARP, has been the focus of many studies aimed at clarifying the biological function of poly(ADP-ribose) (PAR). This …

    arizona-thes Repository record

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