Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 72 for “"RelA"”.
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Developing Novel Models and Therapeutics for ZFTA-RELA Ependymoma
… brain tumours are the leading cause of cancer related death in children. Ependymomas are the third most common brain tumour in children. These tumours are found to be incurable in 40% of cases, in large part because of a lack on new treatments. Thirty percent of all ependymomas occur in the …
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ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
… A (PKAc), a ribosmal S6 kinase that controls RelA Ser 276 phosphorylation. In ATM knockdown cells, TNF-induced RelA Ser 276 phosphorylation is significantly decreased. We further observed decreased binding and recruitment of the transcriptional elongation complex containing cyclin dependent …
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PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY
RelA/p65 is a main subunit of nuclear factor-kappaB (NF-kappaB) that regulates expression of genes involved in cell growth and survival, stress response, and inflammation, but its oncogenic or tumor-suppressive function in tumorigenesis has been highly controversial. Hundreds of NF-kappaB …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… transcription factor nuclear factor- kappa B/ RelA, which binds to the IL-6 promoter and promotes transcription. To investigate the role of fibroblast-RelA in Ang II mediated AAA formation, I aimed to generate fibroblast-specific RelA-deficient mice using Cre-Lox technology. Mice containing Cre …
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The IRAK-1 binding protein SIMPL functions as a p65/RELA co-activator in NF-KB dependent gene expression following tumor necrosis factor-alpha stimulation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Molecular Mechanisms of C11orf95 translocations in cancer.
… of the C11orf95 gene of unknown function and RELA, the canonical nuclear effector of NF-B signalling. Subsequent studies have reinforced our original findings on the frequency (>70%) of these C11orf95-RELA (C11-RELA) fusions in human disease, as well as their transformative potential in …
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Novel Diagnostics and Therapeutic Approaches for Supratentorial Ependymoma
… is characterised by a fusion of C11orf95 and RELA, or less commonly, YAP1. The C11orf95-RELA fusion protein acts as a potent driver of oncogenesis in mouse models, and patients with this form of the disease have a particularly poor prognosis. Here, I describe research to develop a new …
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Host cell signaling in response to RSV infection
… the activating phosphorylation of NF-kappa B /RelA at serine residue 276.\r\nSecondly, I first demonstrated that RIG-I was involved in the activation of NIK/IKK alpha complex, two key noncanonical kinases that induce the protelytic processing of an I kappa B alpha-like inhibitor p100 to p52. I …
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Estudio de genómica comparada de genes bacterianos relacionados con la proliferación en la rizosfera
… of the most studied species for its mutualistic relationship with plants at the rhizosphere level, Pseudomonas putida. It is considered a rhizobacteria that promotes plant growth, also knows as a PGPR (Plant-Growth Promoting Rhizobacteria). The different stages of colonization have been defined, …
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The unfolded protein response regulates hepatocellular injury during the pathogenesis of nonalcoholic steatohepatitis
… inflammation. Depletion of either CHOP or the RELA subunit of NF-κB in hepatocytes alleviated autophagy and cytokine secretion, resulting in enhanced cell viability and lowered inflammatory responses during exposure to saturated FFAs. We carried out next generation sequencing on cells deleted …
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Transcription in Mycoplasma pneumoniae
… weitläufig in Bakterien konservierten Proteine RelA und WhiA fehlen, konnten isoliert werden. Außerdem konnte eine Interaktion zwischen dem Protein Mpn266 und der α-Untereinheit der RNA-Polymerase nachgewiesen werden, ein Hinweis darauf, dass Protein Mpn266 ein Ortholog des …
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… pathways, in particular increase in nuclear p65/RelA and phospho-p65/RelA leading to an increase in NFκB and AP-1 binding to DNA and sustained and hyperactive NFκB response in Arih2-/- dendritic cells. Overall, Ariadne 2 is shown to be a negative regulator in the activation of immune cells, in …
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O horário de verão afeta o desempenho do aluno? Evidência para o Brasil
… identificadas em áreas não diretamente rela- cionadas ao consumo de energia, como ocorre, por exemplo, em educação. Até então, essa política não possuía nenhum impacto em desempenho estudantil ao considerar uma distân- cia em dias entre o início do HV e a realização de testes …
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<i>Haemophilus influenzae</i> modulins in chronic obstructive pulmonary disease airway inflammation
… of four proteins, ClpB, OmpP2, TonB, and RelA, suggested a potential role in the IL-8 response. A fifth protein, FtsH, showed no such response. Study of the other 22 proteins is required to understand their role in cytokine induction. These results suggest that factors other than …
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Estrutura da variação craniana em populações de Bolomys lasiurus (Lund, 1841) (Rodentia: Cricetidae) do Nordeste do Brasil
… Brazil is investigated. ln a first step, the correlation structures between tooth wear and suture ossification indexes are evaluated to access possible effects of sex, vegetation, season and local variation among samples of 31 sites on craniodental estimators of rela tive age and to improve age …
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Characterization of the vaccinia virus ankyrin repeat protein K1 on NF-κB inhibition and its contributions to viral pathogenesis
… for K1: K1 inhibited nuclear acetylation of the RelA (p65) subunit of NF-κB. Moreover, p65-CBP interactions were blocked in the presence of K1. However, K1 did not preclude NF-κB binding to oligonucleotides containing B binding sites. This implies that NF-κB-promoter interactions still occurred …
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Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… of 16 genes including FGR (P=0.003), RELA (P=0.049), LTBP3 (P=0.050), and RIN1 (P=0.023) were significantly associated with shorter time to tumor recurrence. On multivariate analysis, FGR and XPA were independent risk factor of early recurrence and poor overall survival respectively. …
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Vitamin D and Immunomodulation in Bronchial Asthma
… genes and inflammatory mediators. The p50 and RelA subunits of NF-κB are translocated to the nucleus by importin α3 and importin α4. The potent immunomodulatory role of Vitamin D in both innate and adaptive immunity has recently been appreciated. Calcitriol exerts its action through the Vitamin …
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