Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"Randomized Controlled Trials"”.
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On the measurement of blinding in randomized, controlled trials.
A key feature to many randomized, controlled trials is that they implement a blind; that is, subjects, experimenters, or both are unaware as to which treatment arm an individual has been assigned. The purpose of the blind is to reduce bias and improve retention. The importance of blinding has been …
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Methods for Exploring Heterogeneity in Systematic Reviews of Randomized Controlled Trials
… of three major components: 1. A sample of randomized controlled trials of herbal medicines was collected and assessed with a recently developed extension of the CONSORT statement for herbal medicine trials. 2. A methodological review of proposed methods of assessing clinical heterogeneity …
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EVERYONE IS DOING IT: THE EFFECTIVENESS OF BODY-WORN CAMERAS BEYOND RANDOMIZED CONTROLLED TRIALS
… in two major police departments in which randomized controlled trials (RCTs) of body-worn cameras produced differing results. One RCT showed that the technology reduced the use of force and complaints while the other did not. By examining the effectiveness of other police reform …
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Accounting for Correlation in the Analysis of Randomized Controlled Trials with Multiple Layers of Clustering
… the analysis of data from such clinical trials often omits several aspects of the study design, leading to incorrect or misleading conclusions. In this paper, a major objective is to show via case studies that randomized controlled trials with longitudinal designs must account for …
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Conducting Cluster Randomized Controlled Trials in Hospitals: Barriers and Enablers Assessment and Strategies to Facilitate Delivery
Background: Cluster randomized control trials (cRCTs) are useful for asking about system-level interventions compared to other types of clinical research design, however they present unique challenges with conduct and delivery. Numerous cRCTs in hospitals have encountered challenges and time delays …
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The Efficacy and Attrition Risk of Video-Based Versus In-Person Psychotherapy for Depression: A Meta-Analysis of Randomized Controlled Trials
… PSYCinfo, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for articles from January 1, 2000 to May 1, 2020. A random-effects meta-analysis was conducted to evaluate potential differences in efficacy rates between the videoconferencing and in-person …
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How much compliance is enough? Examining the effect of different definitions of compliance on estimates of treatment efficacy in randomized controlled trials.
… being classified as compliers if they had been randomized to treatment. No studies have systematically examined how sensitive CACE estimates are to different definitions of compliance. This study hypothesizes that incorrect definitions of compliance can bias CACE estimates and seeks to determine …
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Does direct observation of antiretroviral therapy improve outcomes for HIV/AIDS patients compared to non-observed therapy?: A systematic review and meta-analysis of randomized-controlled trials
Highly active antiretroviral therapy (HAART) has dramatically affected the course of HIV disease, resulting in a significant reduction in AIDS-related morbidity and mortality in both developed and developing countries.
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Enhancing decision making in Randomized Controlled Trials via efficient use of internal and external information - Miglioramento del processo decisionale negli studi clinici randomizzati tramite un uso efficiente delle informazioni interne ed esterne
L'abstract è presente nell'allegato / the abstract is in the attachment
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Effectiveness of Exercise Interventions in Reducing Depressive Symptoms Among Caregivers of People with Dementia: A Systematic Review
… review was to synthesize evidence from randomized controlled trials examining the effects of exercise interventions on depressive symptoms among informal dementia caregivers and to explore potential moderators related to intervention, participant, and methodological characteristics. A …
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Causal inference for complex data: randomization inference for treatment effect heterogeneity, network outcomes, and subgroup specific effects
… presents three new methodologies for analyzing randomized controlled trials using the researcher controlled randomization mechanism as the basis for inference. The first method extends inference for the ``attributable effect'', the total of the difference of outcomes if the treatment group had …
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Surveillance Imaging Following Curative-Intent Surgery for Non-Small Cell Lung Carcinoma: A Systematic Review
… studies were included in this analysis. No randomized controlled trials were identified. A total of 1019 recurrences and second primary lung cancers were detected among 2716 patients. 53.1% of cases were detected by surveillance protocol (OR 1.28, 95% CI 0.97-1.69). 34.9% of patients were …
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Evidence aggregation in development economics via Bayesian hierarchical models
… or risk ratios. The applications considered are randomized controlled trials of expanding access to microcredit and randomized access to vitamin A supplementation in developing nations.
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Barriers to patient enrolment in oncology clinical trials at a Canadian regional cancer centre: a mixed methods study
Background: Randomized controlled trials are required to assess the safety and efficacy of new cancer medications in humans for marketing approval. Thereby, efforts to inform strategies to improve low enrolment rates are imperative to prevent slower rates and increased cost of development. The aim …
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Cost effectiveness analysis of abacavirlamivudine versus tenofoviremtricitabine combination therapy as part of highly active antiretroviral therapy in treatment naive HIV-infected patients
… literature was performed to identify relevant randomized controlled trials and economic models. The economic model described by Richter using maximal virologic response and rate of failure as efficacy parameters was adapted to take into consideration the effect of HLA-B*5701 genotyping. …
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RANDOMISED CONTROLLED TRIALS ON PSYCHOLOGICAL INTERVENTIONS TO PROMOTE MENTAL HEALTH OF COMMUNITY-DWELLING ELDERLY
… well-being, prompted us to initiate two randomized-controlled trials. Methods: Systematic review and meta-analysis were employed to examine aggregate serum BDNF levels. Subsequently, to examine the effects of the interventions, biomarkers candidates and psychometric measures were …
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Towards Precision Oncology: A Predictive and Causal Lens
… these methods with experimental data from Randomized Controlled Trials (RCTs), quantifying the uncertainty in the predictions, and finally, exploring how these elements can be woven together into a clinical decision support tool. In this thesis, I explore each of these aspects in turn: i) …
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TB or Not TB: Treatment of Latent Tuberculosis Infection in Harlem, New York
… completion of, LTBI treatment in two separate randomized controlled trials. Data for these analyses are drawn from two sequential randomized controlled trials designed to compare a peer-based intervention to usual care for ensuring completion of treatment for LTBI in an urban clinic setting: …
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Characterisation of mucosal tissue in the foreskin after voluntary medical male circumcision
… acquisition by up to 60% as shown in a number of randomized controlled trials in Uganda, Kenya and South Africa. MMC has also been shown to reduce the prevalence of other sexually transmitted infections (STIs) like Herpes Simplex Virus (HSV) -2 and Human Papillomavirus (HPV) by 25% and 35% …
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Role of Lifestyle Modifications in the Management of Hidradenitis Suppurativa in Adults: A Systematic Review [paper]
… mitigated with lifestyle modifications. However, randomized controlled trials are needed to determine how much lifestyle modification independently affects hidradenitis suppurativa.
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