Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 138 for “"RAF"”.
-
Role of Raf family members in mouse development
Raf Proteine sind Serin/Threonin Kinasen, die als zentrale Elemente des Ras, Raf, Mek, Map Kinase Wegs, an der Weiterleitung von extrazellulären Signalen von der Zellmembran zu nukleären Effektoren beteiligt sind. Auf diese Weise kontrollieren sie elementare Prozesse wie Proliferation, …
-
The Role of Raf-mediated Signalling Pathways for Motoneuron
… of intracellular signalling proteins. The Ras/Raf/MEK/MAPK signalling pathway has been shown to control the expression of genes which are crucial for the physiological regulation of cell proliferation, differentiation and apoptosis. Within this signalling cascade, the Raf protein family of …
-
Regulation of C-RAF stability by the RanBPM/CTLH complex
… the ERK1/2 pathway through the modulation of C-RAF protein levels. This study shows that RanBPM-mediated degradation of C-RAF occurs through the proteasome and the entire CRA domain of RanBPM is necessary for direct interaction with C-RAF and for effective downregulation of C-RAF in human cells. …
-
Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
RKIP (Raf-1 kinase inhibitory protein) is a novel potent metastasis suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory …
-
Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
RKIP (Raf-1 kinase inhibitory protein) is a novel potent metastasis suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of many different cancers and inflammatory …
-
Grassland Dynamics on Revetments at RAF Caerwent, Monmouthshire, South Wales
A chronosequence method was used to study plant community changes over successional time in a replicated design over an interval of 56 years. Artificial earthworks (revetments) constructed in 1939 and 1968 within a military manufacturing facility have been maintained under a constant regime of …
-
Combat stress reaction and morale in RFC/RAF aircrew 1914-1918
… issues, on the technical development of aircraft or the skill and daring of the aircrew concerned. The effects of the dangers of flying and air combat, which tested aircrew to their limits both physical and mental with consequent psychological disorders have been ignored. This study examined …
-
Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
… proteins and mediate T cell migration and trafficking by binding to ECM or other cells, as well as initiating intracellular signaling cascades promoting survival or activation. The mitogen activated-protein kinase (MAPK) pathway is known to be downstream from integrins and regulate survival, …
-
RAF-1 kinase inhibitor protein-mediated cholecystokinin-2 receptor desensitization and extracellular signal-regulated kinase activation
Raf-1 kinase inhibitor protein (RKIP) is initially known as a suppressor for Raf-1-mediated ERK activation. Moreover, recent findings indicate that RKIP also has a role in G-protein-coupled receptor (GPCR) desensitization. Protein kinase C (PKC)-mediated phosphorylation at Serine 153 (S153) on RKIP …
-
Dialogue and Resistance. An Evaluation of Two Approaches to Peace Campaigning at RAF Molesworth (1980-1987)
… was put to the test over a seven-year period at RAF Molesworth in Cambridgeshire, in a series of campaigns which were attempting to stop deployment of Cruise Missiles there. Some campaigns concentrated on efforts to convert, others relied on the power of nonviolent direct action to coerce. None …
-
Why Was the RAF So Committed to the "Area Bombing" of Germany in the Second World War?
'To a handful of individuals invested with the disproportionate powers conferred by totalitarian war, millions of Germans, Italians and French owe the devastation of beautiful historic towns, and thousands of families in enemy occupied countries the death, injury, or mental derangement of young, …
-
Mouse Oocyte Maturation and Embryo Development After Exposure to Vemurafenib (PLX4032), an Anti-Melanoma B-RAF V600E Inhibitor
<p>Vemurafenib is a selective B-Raf<sup>V600E</sup> inhibitor in melanoma targeted therapy which also inhibits the wild type B- and C-Raf. In oocyte maturation, the C-Raf/MAPK pathway acts as an important self-enhancing and promoting system, w hereas in embryo development, the C-Raf/M APK pathway …
-
Lessons learned and unlearned, the theory and practice of employing airpower in small wars, the RAF, 1910 – 2010.
… determine whether or not during this period the RAF can be considered a learning organisation. By undertanding this a better determination can be made as to the effectiveness of the RAF in a small wars environment in the past, and its ability to be succesful in current and future operations. This …
-
Kartierung krebsrelevanter Signalwege
… und Apoptose beteiligt. Proteinkinasen der Raf-Familie wirken dort als signalübertragende Elemente, welche Membranrezeptoren nachgeschaltet sind. Diese Proteine fungieren als Proto-Onkogene, eine Veränderung dieser Proteine kann sie in Onkogene überführen und sind wesentlich an der …
Page 1 of 7