Global ETD Search

1. 1

   Synthesis of Bicyclic Thieno[2,3-d]Pyrimidines, Tricyclic Thieno[2,3-d]Pyrimidines and Thieno[3,2-d]Pyrimidines as Classical and Nonclassical Antifolates

   Zhou, Xilin2018

   … d /italic ]- and theino[3, 2- italic d /italic ]pyrimidines were synthesized as antimitotic agents. These compounds allowed potent inhibition of tumor cells in culture and extended the structure-activity relationship in the antimitotic area.

   duquesne Repository record for Synthesis of Bicyclic Thieno[2,3-d]Pyrimidines, Tricyclic Thieno[2,3-d]Pyrimidines and Thieno[3,2-d]Pyrimidines as Classical and Nonclassical Antifolates (opens in a new tab)

2. 2

   Synthesis of pyrrolo[2,3-d]pyrimidines and pyrazino[2,3-d]pyrimidines and their biological activities

   Lee, Jeong-HwanUniversity of Strathclyde2010

   Pyrrolo[2,3-d]pyrimidines and pyrazino[2,3-d]pyrimidines were synthesised to investigate their biological activities to eventually produce potential new antifolates. Funtionalised nitroalkenes were successfully added to the C5 of 2-thioalkyl-6-amino-4-oxopyrimidines via a Michael reaction. …

   strathclyde Repository record for Synthesis of pyrrolo[2,3-d]pyrimidines and pyrazino[2,3-d]pyrimidines and their biological activities (opens in a new tab)

3. 3

   Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.

   Hildick, Brian G.University of Bradford2010

   … uracils, pyrazoles and pyrazolo [3,4-d] - pyrimidines with alkyl, aryl and glycosyl substituents such that the nature of the ring substituents is easily varied. To this end a number of ethoxymethylene reagents were prepared which, by reaction with primary amines and hydrazines, would give …

   bradford Repository record for Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives. (opens in a new tab)

4. 4

   Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents

   Zhang, Xin2018

   … for activity. Fifty - seven furo[2,3- d ]pyrimidines and six thieno[2,3- d ]pyrimidines were designed on iv the basis of crustal structures and synthesized as potential RTK inhibitors with antimitotic antitumor activity. Four pyrrolo[2,3- d ]pyrimidines were design ed and synthesized as …

   duquesne Repository record for Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents (opens in a new tab)

5. 5

   Reactions of pyrimidines and purines with hydroxylamine

   Osborne, Martin RoyUniversity of Cambridge1971

   cambridge Repository record for Reactions of pyrimidines and purines with hydroxylamine (opens in a new tab)

6. 6

   Syntheses and reactions of thieno [2,3-d] pyrimidines

   Shahhet, MS2026

   Thieno [2,3-d] pyrimidines have, so far, been synthesised mainly from thiophen derivatives. The work described in this thesis is largely concerned with a search for general methods of synthesising substituted thieno [2,3-d] pyrimidines from pyrimidines.

   salford Repository record for Syntheses and reactions of thieno [2,3-d] pyrimidines (opens in a new tab)

7. 7

   Pyrimidines and the X-Ray Response of Tribolium Confusum

   Hogan, Gene RichardUniversity of Illinois at Urbana-Champaign2014

   Made available in DSpace on 2014-12-09T23:33:55Z (GMT). No. of bitstreams: 1 6607754.pdf: 3788031 bytes, checksum: 148e9f57695531488fd448035e33dede (MD5) Previous issue date: 1966

   uiuc Repository record for Pyrimidines and the X-Ray Response of Tribolium Confusum (opens in a new tab)

8. 8

   Dimroth rearrangement in 4(6)-imino-pyrimidines and related systems

   Ienaga, Kazuharu1975

   aus-cath Repository record for Dimroth rearrangement in 4(6)-imino-pyrimidines and related systems (opens in a new tab)

9. 9

   Dimroth rearrangement in 4(6)-imino-pyrimidines and related systems

   Ienaga, Kazuharu1975

   anu Repository record for Dimroth rearrangement in 4(6)-imino-pyrimidines and related systems (opens in a new tab)

10. 10

    Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents

    Yang, Si2018

    … of synthesizing these pyrrolo[2,3-<em>d</em>]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-<em>d</em>]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to achieve better yield.</p>

    duquesne Repository record for Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents (opens in a new tab)

11. 11

    THE ROLE OF PURINES AND PYRIMIDINES IN BOVINE RED BLOOD CELL METABOLISM

    Seider, Michael John, 1951-The University of Arizona.1977

    arizona-thes Repository record for THE ROLE OF PURINES AND PYRIMIDINES IN BOVINE RED BLOOD CELL METABOLISM (opens in a new tab)

12. 12

    Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors

    Lin, Lu2018

    … on the synthesis of substituted pyrrolo[2, 3-d]pyrimidines as potential anticancer agents that act via microtubule inhibition or HSP90 inhibition..</p><p> Microtubule-binding agents are effective against a broad range of tumors and lymphomas and have been common components of combination …

    duquesne Repository record for Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors (opens in a new tab)

13. 13

    The Effect of Pressure on The Electronic Structure of Some Purines, Pyrimidines, and Aromatic Hydrocarbons

    Okamoto, Byron YoshiharuUniversity of Illinois at Urbana-Champaign2015

    Made available in DSpace on 2015-05-12T22:32:05Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7511564.PDF: 4395169 bytes, checksum: ac96475062316eaf2fc516c99689a05d (MD5) Previous issue date: 1974

    uiuc Repository record for The Effect of Pressure on The Electronic Structure of Some Purines, Pyrimidines, and Aromatic Hydrocarbons (opens in a new tab)

14. 14

    Stereoselective monoalkyl diazene synthesis for mild reductive transformations : direct synthesis of densely substituted pyridines and pyrimidines

    Ahmad, Omar K. (Omar Khaled)Massachusetts Institute of Technology2011

    … the corresponding C4-heteroatom substituted pyrimidines is described. The use of cyanic bromide and thiocyanatomethane in this chemistry provides versatile azaheterocycles poised for further derivatization. The synthesis of a variety of previously inaccessible C2- and C4- pyrimidine …

    mit Repository record for Stereoselective monoalkyl diazene synthesis for mild reductive transformations : direct synthesis of densely substituted pyridines and pyrimidines (opens in a new tab)

15. 15

    The Synthesis of Bicyclic Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases, Microtubules or HSP90

    Kurup, Sonali2019

    <p>Abstract withheld</p>

    duquesne Repository record for The Synthesis of Bicyclic Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases, Microtubules or HSP90 (opens in a new tab)

16. 16

    Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection

    Shah, Khushbu2018

    … dissertation discusses the development of fused pyrimidines, aimed to inhibit tubulin polymerization as well as act as antiangiogenic agents which inhibit one or more of the receptor tyrosine kinases (RTKs)- vascular endothelial growth factor receptor-2 (VEGFR2), platelet derived growth factor …

    duquesne Repository record for Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection (opens in a new tab)

17. 17

    Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies

    Wang, Yiqiang2018

    … 5-, 6- and 7-substituted pyrrolo[2, 3-d]pyrimidines were designed and synthesized. Extensive structure modifications of the pyrrolo[2, 3-d] pyrimidine scaffold were investigated to determine selective transport via FR or/and PCFT and tumor targeted antifolates with GARFTase or multiple …

    duquesne Repository record for Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies (opens in a new tab)

18. 18

    The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions

    Namjoshi, Ojas2019

    <p>Abstract withheld</p>

    duquesne Repository record for The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions (opens in a new tab)

19. 19

    Synthesis of 2,4-Diaminopyrido [2,3-d] pyrimidines and 2,4-Diaminoquinazolines as Inhibitors of Dihydrofolate Reductase and as Anti-tumor Agents

    Adair, Ona2019

    <p>Abstract withheld</p>

    duquesne Repository record for Synthesis of 2,4-Diaminopyrido [2,3-d] pyrimidines and 2,4-Diaminoquinazolines as Inhibitors of Dihydrofolate Reductase and as Anti-tumor Agents (opens in a new tab)

20. 20

    Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies

    Li, Xinxin2019

    … classical 6- substituted pyrrolo[2,3-<em>d</em>]pyrimidines and 5-substituted pyrrolo[2,3-<em>d</em>]pyrimidines as potential antifolates have been described. The design variations include: methylated thiophene regioisomers, fluorinated phenyl regioisomers, thionyl regioisomers on the side chain …

    duquesne Repository record for Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies (opens in a new tab)

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