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Showing 1 to 20 of 45 for “"Prothrombin"”.
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Quantitative estimates of prothrombin components
Thesis (M.S.)--Michigan State University. Dept. of Pathology, 1969
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Study of prothrombin activation by taipan snake venom using light beating spectroscopy
… first time to measure the dynamic properties of prothrombin and its activation kinetics via Taipan Snake Venom, micellar phospholipid and Ca++. The correlation times fCc) on the samples of human prothrombin, which were prepared by membrance filtering techniques, were measured as a function of …
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Studies of structure-function relationships in two human coagulation proteins: factor XII and prothrombin
… inhibiting activation. During activation of prothrombin by the prothrombinase complex (FXa, FVa, phospholipids and Ca++), transient activation intermediates are produced. The intermediate meizothrombin has enzymatic activity but very little coagulant activity while intermediate prethrombin-2 …
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Studies on the Mechanism of Polyamine-and Prothrombin kringle-2-induced Degeneration of Neuron and Microglia
… on dopaminergic neurons in vivo and in vitro. Prothrombin kringle-2 acts as an proinflammtory agent that activates microglia to release pro-inflammatory mediators. Intracortical injection of pKr-2 caused significant loss of cortical neurons in vivo after seven days, as evident from Nissl …
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Poor anticoagulation control in patients taking warfarin at a tertiary and district-level prothrombin clinic in Cape Town, South Africa
Background. Warfarin is the most commonly used anticoagulant for both primary and secondary prevention of thromboembolism. For anticoagulation efficacy, the international normalised ratio (INR) needs to be within the therapeutic range for at least 65% of time on warfarin. Objectives. To describe …
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Urinary prothrombin fragment 1 : a potential role-player in the protection of South African blacks from calcium oxalate kidney stone disease
… of the inhibitory role of the protein, urinary prothrombin fragment 1 (UPTFI ), and its biochemical characterisation in both population groups. In a preliminary study, the urine composition and inhibitory activity of urine and urinary macromolecules from healthy white and black subjects was …
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Comparisons among genetically diverse lines of chickens for blood coagulation factors
… of specific coagulation factors was warranted. Prothrombin time, thrombocyte concentration and plasma fibrinogen concentration was investigated in two of the most diverse lines to determine their relative contribution towards variation in coagulation time. Highly significant differences between …
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Studies of Coagulation and Fibrinolysis
The mechanism and regulation of prothrombinase function in the activation of prothrombin and prethrombin-1 were studied. In addition, the kinetics of plasmin-mediated fibrin degredation were determined. First, the mechanism of prothrombin activation by prothrombinase was investigated using two …
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Kapilläre Thromboplastinzeit : Untersuchung zur Validität des INR-Wertes aus Kapillarblut bei Kindern mit und ohne Marcumartherapie mit Hilfe des CoaguChek-Systems
… were developed in the last years to measure the prothrombin time with capillary blood. To evaluate the reliability of this method during childhood we examined in a prospective study 334 blood samples (175 capillary, 149 venous, 10 arterial blood) of 94 children (age: 1-18; median: 6,11 years) …
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Studies on the pathology of arsanilic acid toxicity in calves
… the last two or three days preceding death. 4) Prothrombin time is gradually increased from the first ingestion of arsanilic acid reaching the highest values two days before death. Increases in prothrombin time occurred even on low levels of arsanilic acid which produced no other clinical or …
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FUNCTIONAL STUDIES WITH DIRECT ORAL ANTICOAGULANTS: INVESTIGATION OF THE REGULATION OF KEY BLOOD COAGULATION PROTEASES
… the key upstream propagator of thrombin, the prothrombinase enzyme complex, is also resistant to the AT-heparin. Our data show that further upstream of prothrombinase, the intrinsic tenase is only moderately protected, while there is no protection at the level of the initiator complex, …
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Neue Strategien zum Nachweis klinisch relevanter Polymorphismen
… Parametern (HPA-1, Gerinnungsfaktor V, Prothrombin, ACE) und dem Auftreten eines Myokardinfarktes aufweisen. Allerdings konnte gezeigt werden, daß es zu einem signifikant höherem Herzinfarktrisiko bei einer Kombination von Diabetes und dem HPA-1b Typ kommt und die Frequenz der …
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Perioperative Veränderungen der Hämostase bei langdauernden onko-gynäkologischen Operationen
… included partial thromboplastin time (PTT), prothrombin time (PT), thrombin time (TT), fibrinogen, D-dimer, antithrombin III and fibrin monomer. All patients showed signs of haemostatic abnormality. Preoperatively, compensated DIC with signs of hypercoagulation were evident. Postoperatively, …
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Choline Inhibition of Prothrombinase
… site of inhibition being the step that converts prothrombin (II) to thrombin (IIa).</p> <p>In order to quantitate the effects of choline on prothrombinase activity, bovine factor V and human factor II were isolated in this laboratory by established methods, and other prothrombinase components …
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Thrombelastographische Blutgerinnungsuntersuchungen gesunder Schweine unter Xenonmono- bzw. einer Kombinationsnarkose aus Xenon und den volatilen Inhalationsanästhetika Isofluran, Sevofluran, Halothan und Enfluran
… tests (activated thromboplastin time, prothrombin time, fibrinogen concentrations, platelet count) and thrombelastographic measurements were made. Thrombelastography has proven to be a useful monitor of the coagulation process from initiation of clotting to the final stages of clot …
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The regulation of blood coagulation by high-density lipoprotein particles
… HDL was studied in its ability to stimulate prothrombin activation. Anionic phospholipids lost their procoagulant function when incorporated into reconstituted HDL particles. The anionic phospholipids of these particles were unable to support binding to activated factor V (FVa). Serum was …
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Changes in the clotting viscoelasticity caused by cardiopulmonary bypass (CPB) surgery
… ([eta]'max) and the coagulation parameters prothrombin time (PT), platelet count, fibrinogen concentration and hematocrit are all affected by CPB; 3) The TVE-derived parameters were all substantially affected by incubation of the blood with the platelet GP inhibitor suggesting that these …
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Evaluation of hemostasis in hyperthyroid cats
… euthyroid cats > 8 years of age were studied. Prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, antithrombin (AT), D-dimers, thrombin-antithrombin complexes (TAT), von Willebrand Factor antigen (vWF:Ag), and activity of factors VIII and IX were measured. An …
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Thrombophilie als mögliche Ursache für vorzeitige Plazentalösung
… (46.43%) had either a factor V suffering, a prothrombin or MTHFR mutation or were carrier of the PAI 4G/4G polymorphism. Combined genetic defects only occurred with the 4G/4G variant in the PAI gene. Compared to information based on contemporary literature all mutations, except for the MTHFR …
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