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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Prothrombin"”.
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Quantitative estimates of prothrombin components
Thesis (M.S.)--Michigan State University. Dept. of Pathology, 1969
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Study of prothrombin activation by taipan snake venom using light beating spectroscopy
… first time to measure the dynamic properties of prothrombin and its activation kinetics via Taipan Snake Venom, micellar phospholipid and Ca++. The correlation times fCc) on the samples of human prothrombin, which were prepared by membrance filtering techniques, were measured as a function of …
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Studies of structure-function relationships in two human coagulation proteins: factor XII and prothrombin
… inhibiting activation. During activation of prothrombin by the prothrombinase complex (FXa, FVa, phospholipids and Ca++), transient activation intermediates are produced. The intermediate meizothrombin has enzymatic activity but very little coagulant activity while intermediate prethrombin-2 …
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Studies on the Mechanism of Polyamine-and Prothrombin kringle-2-induced Degeneration of Neuron and Microglia
… on dopaminergic neurons in vivo and in vitro. Prothrombin kringle-2 acts as an proinflammtory agent that activates microglia to release pro-inflammatory mediators. Intracortical injection of pKr-2 caused significant loss of cortical neurons in vivo after seven days, as evident from Nissl …
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Poor anticoagulation control in patients taking warfarin at a tertiary and district-level prothrombin clinic in Cape Town, South Africa
Background. Warfarin is the most commonly used anticoagulant for both primary and secondary prevention of thromboembolism. For anticoagulation efficacy, the international normalised ratio (INR) needs to be within the therapeutic range for at least 65% of time on warfarin. Objectives. To describe …
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Comparisons among genetically diverse lines of chickens for blood coagulation factors
… of specific coagulation factors was warranted. Prothrombin time, thrombocyte concentration and plasma fibrinogen concentration was investigated in two of the most diverse lines to determine their relative contribution towards variation in coagulation time. Highly significant differences between …
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Urinary prothrombin fragment 1 : a potential role-player in the protection of South African blacks from calcium oxalate kidney stone disease
… of the inhibitory role of the protein, urinary prothrombin fragment 1 (UPTFI ), and its biochemical characterisation in both population groups. In a preliminary study, the urine composition and inhibitory activity of urine and urinary macromolecules from healthy white and black subjects was …
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Studies of Coagulation and Fibrinolysis
The mechanism and regulation of prothrombinase function in the activation of prothrombin and prethrombin-1 were studied. In addition, the kinetics of plasmin-mediated fibrin degredation were determined. First, the mechanism of prothrombin activation by prothrombinase was investigated using two …
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Studies on the pathology of arsanilic acid toxicity in calves
… the last two or three days preceding death. 4) Prothrombin time is gradually increased from the first ingestion of arsanilic acid reaching the highest values two days before death. Increases in prothrombin time occurred even on low levels of arsanilic acid which produced no other clinical or …
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Neue Strategien zum Nachweis klinisch relevanter Polymorphismen
… Parametern (HPA-1, Gerinnungsfaktor V, Prothrombin, ACE) und dem Auftreten eines Myokardinfarktes aufweisen. Allerdings konnte gezeigt werden, daß es zu einem signifikant höherem Herzinfarktrisiko bei einer Kombination von Diabetes und dem HPA-1b Typ kommt und die Frequenz der …
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Choline Inhibition of Prothrombinase
… site of inhibition being the step that converts prothrombin (II) to thrombin (IIa).</p> <p>In order to quantitate the effects of choline on prothrombinase activity, bovine factor V and human factor II were isolated in this laboratory by established methods, and other prothrombinase components …
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The regulation of blood coagulation by high-density lipoprotein particles
… HDL was studied in its ability to stimulate prothrombin activation. Anionic phospholipids lost their procoagulant function when incorporated into reconstituted HDL particles. The anionic phospholipids of these particles were unable to support binding to activated factor V (FVa). Serum was …
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Changes in the clotting viscoelasticity caused by cardiopulmonary bypass (CPB) surgery
… ([eta]'max) and the coagulation parameters prothrombin time (PT), platelet count, fibrinogen concentration and hematocrit are all affected by CPB; 3) The TVE-derived parameters were all substantially affected by incubation of the blood with the platelet GP inhibitor suggesting that these …
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Evaluation of hemostasis in hyperthyroid cats
… euthyroid cats > 8 years of age were studied. Prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, antithrombin (AT), D-dimers, thrombin-antithrombin complexes (TAT), von Willebrand Factor antigen (vWF:Ag), and activity of factors VIII and IX were measured. An …
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Characterization of a secreted escherichia coli 086a:K61 protease that inactivates human coagulation FV
… FVa, functions in prothombinase to accelerate prothrombin to thrombin conversion by 300,000-fold. The ability of E.coli O86a:K61 to cause intestinal hemorrhage is of interest because previous research demonstrated that during E.coli O86a:K61 sepsis in baboons, a dose-dependent inactivation of …
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… reduced thrombus mass and prolonged both prothrombin time (PT) and activated partial thromboplastin time (aPTT). Overall, our results indicate that PF-04886847 is a novel, potent small molecule inhibitor of plasma kallikrein that would be useful for the treatment of kallikrein-mediated …
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Chrysophanol-8-O-glucoside Attenuates Platelet Activation Through Inhibiting MAPK and PKCε
… tests, CP-8-O-glcglucoside did not alter prothrombin time (PT), and it prolonged the activated partial thromboplastin time (aPTT). However, CP-8-O-glc only inhibited platelet phosphatidylserine exposure, but not direct inhibition on intrinsic factors. To reveal the inhibition mechanism of …
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A Prospective, Descriptive Study Evaluating The Evolution Of Covid-19 Associated Coagulopathy In Mechanically Ventilated, Critically-Ill Patients Using Standard Laboratory Coagulation Studies And Thromboelastography
… D-dimer and fibrinogen levels, prolonged prothrombin times (PT), normal platelet counts and activated partial thromboplastin times (aPTT). No significant differences in laboratory coagulation studies and TEG analysis were noted between survivors and non-survivors on admission. The …
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Contribution of different types of phospholipids in blood coagulation
… (GLA) domains of factor X (fX) and prothrombin as representative GLA domains of clotting factors, which have been the subject of several protein-phospholipid interaction studies. Based on the results of this project, we proposed a new mechanism for the binding of GLA domains of …
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