Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 939 for “"Pro-inflammatory"”.
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Suppression of pro-inflammatory signalling pathways by sulforaphane
… disease mortality and circulating levels of pro-inflammatory cytokines. Sulforaphane (SF), an isothiocyanate obtained from broccoli, has many biological functions. The aim of this thesis was to test whether SF was able to suppress pro-inflammatory signalling using in vitro models of chronic …
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Targeting pro-inflammatory mediators to treat visceral pain
Visceral pain is a prominent cause of morbidity in gastrointestinal (GI) diseases, like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), but many current analgesics produce GI side effects. To develop much needed, novel treatments, further understanding of the pro-inflammatory …
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Elucidating Purinergic and Pro-inflammatory Signaling Mechanisms in Breast Cancer
… Concomitantly, tumor-stromal interactions promote the accumulation of stimulatory factors that augment the wound healing response, inflammation, and metastatic dissemination. While the convergence of these signaling compartments is known to preface malignancy, the molecular mechanisms that …
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Human S100A8 and S100A9 Scavenge Pro-inflammatory Hypohalous Acids in Disease
… S100A9 and S100A12 are generally considered pro-inflammatory proteins because their expression is elevated in chronic inflammatory disorders. Hypohalous acids generated by activated phagocytes are scavenged by murine S100A8 and S100A9, suggesting a protective role in oxidative stress, but …
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MODELING PRO-INFLAMMATORY CROSSTALK BETWEEN MICROGLIA AND ASTROCYTES DURING HIV INFECTION
… We have shown that our iMg also support productive HIV infection, though at a reduced level compared to macrophages. Additionally, we show that iMg exhibit a weaker immune response to HIV challenge than macrophages. Based on this observation, we included iPSC-derived astrocytes (iAst) in …
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Elucidating the mechanism of mitochondrial superoxide production in pro-inflammatory macrophages
Pro-inflammatory macrophages produce reactive oxygen species (ROS) which act as bactericidal agents and redox signals. Recently, mitochondria were identified as an important source of ROS in pro-inflammatory macrophages and it has been proposed that lipopolysaccharide (LPS) stimulated macrophages …
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Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy
… are steroid hormones widely prescribed to treat inflammatory disorders and are regarded as anti-inflammatory molecules. GCs classically induce the expression of antiinflammatory genes, while repressing pro-inflammatory genes via its endogenous cell receptor; the glucocorticoid receptor (GR). …
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Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide
… which induce a strong but transient induction of pro-inflammatory mediators, low doses of endotoxin result in a mild but chronic induction of pro-inflammatory genes. The central hypothesis of our study was that if low doses of endotoxin are capable of inducing mild prolonged inflammation, then a …
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Acute Pro-inflammatory Immune Response Following Different Resistance Exercise Protocols in Trained Men
… CD14++CD16- monocytes that support the proliferation and differentiation of myogenic precursor cells. Physiologically, the magnitude of the cellular response following resistance exercise is dictated by the level of receptor expression on the plasma membrane of the monocyte, as well as …
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Metabolism in Vascular Endothelial Cells: Effects of Hyperglycaemia, Pro-Inflammatory Cytokines and Polyphenols
… the deleterious effects of hyperglycaemic or inflammatory conditions on the vascular endothelium by modulating endothelial cell metabolism. Results: First, the effects of high-glucose concentrations, inflammatory cytokines and polyphenols on markers of endothelial cell function in HUVECs were …
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High MUC2 Biosynthesis and Production Augment Pro-Inflammatory Responses in Colonic Goblet Cells
… amoebiasis, caused by the human intestinal protozoan parasite, Entamoeba histolytica, goblet cells hypersecrete and become depleted of MUC2 mucin, impairing the protective mucus barrier to allow the parasite to contact the colonic epithelium and induce a robust pro-inflammatory cytokine …
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Non-resolving pro-inflammatory macrophage polarization by super-low doses of bacterial endotoxin
… been observed in patients suffering from chronic inflammatory diseases such as atherosclerosis, diabetes, and obesity. However, the link between this condition and chronic inflammation is poorly understood. Previous work from our lab has shown that chronic exposure to super-low doses of bacterial …
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Examining effects of milk ferment components on endothelial cell signaling in pro-inflammatory pathways
Atherosclerosis is a complex, multifactorial, inflammatory disease involving cholesterol, endothelial cells, smooth muscle cells, macrophages and platelets. Atherosclerosis, and the associated cardiovascular diseases it contributes to, has been a growing health care and economic concern over the …
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
… on DC activation by measuring TNFα and IL-12 production. There was no significant production of TNFα or IL-12 by bone marrow derived DCs (BMDC) after exposure to PrPSc infected brain homogenate, however, BMDCs had lower capacity to produce IL-12 after secondary stimulation with LPS. …
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Cell death and Pro-inflammatory Cytokine Release of Rat Microglial Cells by Naegleria fowleri
… by (51)^Cr release assay. In addition, the pro-inflammatory cytokine release from microglial cells in co-culture system was estimated. As results with a light and electron microscopes, most of microglial cells were severely destroyed by N. fowleri lysate, showing the necrotic (above 85%) and …
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Thymoquinone is a Novel Ligand which Activates Neu4 Sialidase to Promote a Pro-Inflammatory Response
… and prevention. TQ is believed to share similar properties to the benzoquinones already in use as therapeutic drugs. Based on previous reports on the anti-inflammatory properties of black seed oil and TQ, it was originally hypothesized that TQ would inhibit lipopolysaccharide (LPS)-induced …
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Role of Activated Macrophages and Pro-Inflammatory Cytokines in Placental Trophoblast Invasion and Fetal Outcome
… also been linked to an increased presence of pro-inflammatory cytokine-secreting (activated) macrophages at the fetal-maternal interface. In particular, increased production of tumour necrosis factor-alpha (TNF) by activated macrophages has been implicated as a causative factor mediating …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… neuronal cell death [3]. The pathologic process that develops after stroke is divided into acute (within hours), sub-acute (hours to days), and chronic (days to months) phases [4, 5]. Obviously, the most effective therapy requires the earliest possible intervention e.g. with removal of a …
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Effects of vitamin D on pro-inflammatory cytokines associated with Non-alcoholic fatty liver disease
… liver disorder in the United States, affecting approximately one-third of the population. The prevalence of NAFLD increases to 90% in morbidly obese individuals. Many studies have shown a negative association between NAFLD and vitamin D levels. In fact, low vitamin D levels were correlated to …
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