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Showing 1 to 20 of 83 for “"Pml"”.
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Regulation of NF-κB by PML and PML-RARα
… activity of NF-κB. Promyelocytic Leukemia (PML) is a nuclear protein that forms nuclear bodies (PML NBs), sub-nuclear structures that are associated with transcriptionally active genomic regions that have been implicated in multiple processes such as apoptosis, senescence and anti-viral …
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Defining the mechanism of arsenic-induced degradation of PML
… which fuses the promyelocytic leukaemia (PML) protein to the retinoic receptor alpha (RARa). The PML-RARa oncoprotein disrupts normal retinoic acid signalling and the function of PML nuclear bodies (PML-NBs), subnuclear protein complexes with roles in control of apoptosis and cellular …
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Effective development of cylindrical finite-difference time-domain for electromagnetics applications
… Thus, a conventional perfectly matched layer (PML) can be used to truncate computational regions in numerical methods. This will reduce the memory size and the time to complete the run. However, the accuracy of the PML is necessary in finite-difference time-domain (FDTD) method. It has been …
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Perfectly Matched Layer Absorbing Boundary Conditions for the Discrete Velocity Boltzmann-BGK Equation
<p>Perfectly Matched Layer (PML) absorbing boundary conditions were first proposed by Berenger in 1994 for the Maxwell's equations of electromagnetics. Since Hu first applied the method to Euler's equations in 1996, progress made in the application of PML to Computational Aeroacoustics (CAA) …
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A Higher-Order Perfectly Matched Layer for Open-Region, Waveguide, and Periodic Electromagnetic Problems
… idea of a higher-order perfectly matched layer (PML) is proposed. Using a metric coefficient that includes both the regular and the complex frequency shifted (CFS) PMLs, it is possible to obtain a PML that includes the advantages of both of them. The second-order PML is applied to waveguide, …
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Investigations of cellular stress-responsive proteins and PGF gene expression in human trophoblast
… regulation of mRNA stability, and regulation of PML sequestering protein. We investigate whether these mechanisms occur in hypoxic stressed trophoblast and preeclamptic placenta. Methods: To determine transcript stability, PGF mRNA was measured in normal vs. stressed conditions, and the PGF 3'UTR …
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Lokalisation des antiviralen Mx1 Proteins und seiner assoziierten Proteinkinase in nukleären Einschlusskörperchen
… des SUMO-1-Systems und der sogenannten PML Nuclear Bodies (PML NBs). <br>Im Rahmen der vorliegenden Dissertation konnte durch konfokale Mikroskopie eine enge morphologische Assoziation von Mx1 zu den Proteinen der PML NBs und des SUMO-1-Systems gezeigt werden. Diese morphologischen …
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A study of the john Cunningham virus (jcv) seroprevalence among Zambian adults presenting with “meningoencephalitis” to the university teaching hospital, Lusaka, Zambia
… of progressive multifocal leukoencephalopathy (PML). Infection with the JCV occurs in childhood and the virus remains quiescent in the body, activating during immunosuppression. Exposure to the virus can be detected by testing for JC virus specific antibodies in an ELISA test. One of the major …
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A study of the john Cunningham virus (jcv) seroprevalence among Zambian adults presenting with “meningoencephalitis” to the university teaching hospital, Lusaka, Zambia
… of progressive multifocal leukoencephalopathy (PML). Infection with the JCV occurs in childhood and the virus remains quiescent in the body, activating during immunosuppression. Exposure to the virus can be detected by testing for JC virus specific antibodies in an ELISA test. One of the major …
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Analysis and Application of Perfectly Matched Layer Absorbing Boundary Conditions for Computational Aeroacoustics
<p>The Perfectly Matched Layer (PML) was originally proposed by Berenger as an absorbing boundary condition for Maxwell's equations in 1994 and is still used extensively in the field of electromagnetics. The idea was extended to Computational Aeroacoustics in 1996, when Hu applied the method to …
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EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿
… (AML) driven by the oncogenic fusion protein PML-RAR, which acts as an aberrant transcription factor and blocks myeloid maturation at the promyelocyte stage. In vivo, the expression of PML-RAR is necessary but not sufficient for full-blown leukemia: knock-in (KI) mouse models of APL undergo …
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Penalized maximum likelihood method for reducing limited-angle artifacts in image reconstructions for a dual-panel high-spatial-resolution pet system
… work, we study a penalized maximum likelihood (PML) image reconstruction method for reducing the limited-angle artifacts arising from the insufficient angular sampling. A prior image is pre-reconstructed from a whole-body low-spatial-resolution PET scan. A PML image reconstruction is then …
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Compositional Control of Phase-Separated Cellular Bodies
Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase separated liquids organized by multivalent interactions among proteins and RNA molecules. Although many components of various cellular bodies are known, general principles that define body composition are lacking. …
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A produção mais limpa como geradora de inovação e competitividade : o caso da fazenda Cerro do Tigre
… os principais objetivos da Produção Mais Limpa (PML). Com a adoção da Produção Mais Limpa ainda podem ocorrer impactos ao meio ambiente. Contudo, estes impactos começam a ser revistos, de forma a serem minimizados ou eliminados. O tema desta pesquisa refere-se à Produção Mais Limpa como geradora …
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Novel Concepts for Differential -Equation-Based Electromagnetic Field Simulations
The PML concept is then studied within the language of differential forms to unify the various PML formulations. Finally, the language of differential forms is also utilized to provide a coordinate-free description and analyze consistency properties of the electromagnetic theory on lattice, for PDE …
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Role of Abberant Proteolysis in the Pathogenesis of APL
… of acute myeloid leukemia (AML), is caused by PML-RARN1, a fusion protein resulting from chromosomal translocation involving the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear hormone receptor corepressor (N-CoR) and that …
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A Higher-Order Finite Element Method for Computing the Radar Cross Section of Bodies of Revolution
… The first method is the perfectly matched layer (PML). This method has a number of parameters that must be optimized to obtain good results. Furthermore, the PML must be kept a reasonable distance away from the scatterer, which causes the number of unknowns to be relatively high. To decrease the …
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The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia
… in the fusion of the promyelocytic leukemia: PML) gene with the retinoic acid receptor alpha: RARA) gene. The fusion product, PML-RARA, encodes a functionally altered transcription factor that is the initiating event in APL. To better understand the transcriptional changes associated with APL …
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Efficient mesh truncation techniques for the solution of Maxwell's equations using the finite-difference time domain method
… domain. The Berenger perfectly matched layer (PML) technique is shown to offer the potential for near reflectionless absorption of propagating waves at the expense of additional layers of absorbing material with twice the number of unknowns as in the interior domain. However, since the PML …
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