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Showing 1 to 20 of 31 for “"Pin1"”.
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Pin1 Catalytic and WW Domain Ligands
Pin1 is a peptidyl prolyl isomerase (PPIase) enzyme with two domains, the catalytic domain and the WW domain. Both domains specifically bind pSer/pThr–Pro motifs. Pin1 plays an important role in regulating the cell cycle, and it is involved in many diseases, such as cancer, HIV-1, Alzheimer's …
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Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
An important role of Pin1 is to catalyze the cis-trans isomerization of pSer/Thr-Pro bonds; as such, it plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including Cdc25, c-Jun, and p53. The expression of Pin1 …
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Prolyl Isomerase Pin1 Is a Conditional Tumor Suppressor
<p><p>Pin1 specifically binds to and catalyzes the <i>cis-trans</i> isomerization of phosphorylated-Ser/Thr-Pro motifs, which modulate the stability, localization, and function of numerous Pin1 substrates involved in cell cycle and tumorigenesis. During cell cycle progression, the timely synthesis …
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Pin1: WW domain ligands, catalytic inhibitors, and the mechanism
… that might arrest cancer proliferation. Pin1 is the first phosphorylation-dependent PPIase enzyme to be discovered. The Pin1 regulatory mechanism, acting on other mitotic proteins in vivo and in vitro, remains largely unknown. For the study of Pin1 function, two types of assays were used …
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Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors
Pin1 (protein interacting with NIMA 1) is a peptidyl-prolyl isomerase involved in mitosis. As a potential anti-cancer drug target, Pin1 interacts and regulates the activity of an increasing number of cell cycle enzymes by an unknown mechanism. These cell cycle enzymes include Cdc25, Cdc27, Cyclin …
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The peptidyl-prolyl isomerase Pin1 is required for maintenance of the spindle assembly checkpoint
… curtailing is associated with tumour formation. Pin1 is a peptidyl-prolyl-isomerase with strong preference for phosphorylated Ser-Pro or Thr-Pro motives within its protein substrates. In the present thesis, evidence for the involvement of Pin1 in the maintenance of a robust SAC response is …
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Part 1 Design, Synthesis and Bioactivity of a Phosphorylated Prodrug for the Inhibition of Pin1; Part 2 Conformational Specificity of Cdc25c Substrate for Cdc2 Kinase using LC-MS/MS
… PPIase (peptidyl prolyl isomerase), Pin1 (Protein interacting with NIMA#1), has been found to regulate cell cycle through a simple conformational change, the cis-trans isomerization of phospho-Ser/Thr-Pro amide bonds. A variety of key cell cycle regulatory phosphoproteins, including …
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A mikrocisztin-LR sejtszintű hatásainak vizsgálata Vicia faba modellnövényben és a PIN1 fehérje lokalizációjának kimutatása Arabidopsis thaliana modellnövényben
Szakdolgozatomban a mikrocisztin-LR cianobakteriális toxin hatásait vizsgáltam Arabidopsis thaliana és Vicia faba modellnövényekben.
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The hormonal regulation of PIN protein localisation and its relevance to shoot architecture
… evidence of an age-dependent aspect to PIN1 behaviour. I then demonstrate that NPA-sensitive auxin flux or auxin concentration are insufficient to explain PIN1 behaviour and attempt to identify a mechanism by which PIN1 senses and responds to auxin at a sub-cellular level. Following …
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Integrative high-throughput analyses of aerial morphodynamics in plants
… the patterning of the auxin efflux transporter PIN1 in plant shoots, specifically in the context of flower organ initiation. A method is developed to investigate molecular patterning data of PIN1 from many samples, in 3D. The results indicate that PIN1 patterning is tightly linked to the …
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Regulation of RUNX3 in gastric and breast cancer
… as a tumor suppressor in breast cancer. Pin1 is an isomerase that is over-expressed in human breast cancer. Pin1 specifically isomerizes only the Ser/Thr-Pro bonds in certain proteins, which allows it to act as a molecular switch controlling protein functions. In the second part of this …
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The role of auxin transport in the control of shoot branching
… of the auxin transporter PIN-FORMED1 (PIN1). Buds need to export their auxin across the stem towards the PATS in order to activate, but since PIN1 is mainly expressed in narrow files of cells associated with the stem vasculature, PIN1 itself it is unlikely to facilitate this …
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SECURE PLANT FERTILITY IN A CHANGING CLIMATE
… ANT is a repressor of the auxin transporter PIN1, in this way the ANT repression allows PIN1 expression in the nucellus. In this work, PIN1 is described to be fundamental for auxin transport at the tip of ovule primordia. Here, thanks to the ARF transcription factors, auxin promotes the …
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Functional Analysis of AtVAMP714 gene in Arabidopsis
… AtVAMP714 overexpressors. Immunolocalization of PIN1 and PIN2 showed strong defects in localization. To characterize the development role of VAMP714, SALK null mutants of the AtVAMP714 gene were identified. The mutant phenotype showed an abnormal branching and short root phenotype and PIN1, PIN2 …
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The Role of the SCD1 Protein in Targeting PIN2 Protein in Arabidopsis Thaliana
… the localization of auxin transport proteins PIN1, PIN2, PIN3, MDR1, and AUX1 fused to fluorescent proteins. The PIN protein reporters were expressed in fewer cells at lower intensity in <italic>scd1-1<italic> at 25° C. PIN1 and PIN2 exhibited altered localization and accumulation in …
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The role of auxin and ethylene in adventitious root formation in Arabidopsis and tomato
… the auxin transport proteins ABCB19 and PIN1, are required for efficient adventitious root formation. Transcript levels of PIN1 increased with root excision in hypocotyls, while neither ABCB19 transcripts nor pABCB19:GFP fluorescence was found to change. In contrast, pABCB19
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Regulatory dynamics of axillary bud competition in Arabidopsis
… both BRC1 expression and the removal of the PIN1 auxin transporter from the plasma membrane. The relative influences of these two arms of strigolactone signaling is poorly understood, because they have mostly been studied separately. In this thesis, I first show that both hubs of regulation …
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New Synthetic Polyamines as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease and Cancer: Design, Synthesis and Biological Evaluation
… through caspases activation and to inhibit PIN1 (preliminary result). This last protein is a very promising target because it is overexpressed in many human cancers, it functions as critical catalyst for multiple oncogenic pathways and in several cancer cell lines depletion of PIN1 …
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