Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Phenylephrine"”.
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The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section
… examined whether the prior administration of phenylephrine obtunds these unwanted haemodynamic effects. Methods: Forty pregnant women undergoing elective caesarean section under spinal anaesthesia were randomised to receive either a 50 μg bolus of phenylephrine (Group P) or saline (Group S) …
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ASSESSMENT OF THE FEASIBILITY OF CO-ADMINISTRATION OF PHENOLIC DIETARY COMPOUNDS WITH PHENYLEPHRINE TO INCREASE ITS BIOAVAILABILITY
<p>R-(-)-Phenylephrine (PE) is the most commonly used nonprescription oral nasal decongestant in the United States. It is a selective α1-adrenergic receptor agonist and has many years of safe usage. However, the efficacy of PE is controversial, due to its extensive pre-systemic metabolism, which …
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Autoregulation of Cortical Blood Flow in Response to Phenylephrine Induced Hypertension in the Normocapnic and Hypercapnic Cat
… blood flow in 17 cats during episodes of phenylephrine-induced hypertension, under conditions of normocapnia and, in some cases, hypercapnia. Arterial blood pressure and voltage output from the flow probe thermocouples were recorded continuously with a Physiograph-six monitor.</p> <p>We …
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Investigations into the Actions of Vasopressin Histamine, Isoproterenol, Phentolamine, Phenylephrine, and Propronalol on Flow Through Perfused Rat Livers
The problem. The experiments were intended to elucidate any intrahepatic actions of the drugs employed as presinusoidal or postsinusoidal and to identify any antagonism of the drugs to others. Procedure. Livers were excised and perfused at a constant rate through the portal vein with different …
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Maternal and cardiac output response to vasopressor therapy during spinal anaesthesia for Caesarean Section in severe preeclampsia
… effects of the vasopressors ephedrine and phenylephrine during spinal anaesthesia. Methods: Thirty nine women with treated severe preeclampsia presenting for spinal anaesthesia for caesarean section for a maternal indication, were studied. Baseline maternal haemodynamics were measured in …
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Effect of Long-Term Hypoxia on Myocardial Alpha1- Receptors
… response to the α<sub>1</sub>-adrenergic agonist phenylephrine did not differ significantly between the fetal and adult ventricles.</p> <p>The present study also investigated the effect of long-term high-altitude hypoxemia on the α<sub>1</sub>- and β<sub>1</sub>-adrenergic receptor interaction in …
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A randomised comparison of bolus phenylephrine and ephedrine for the management of spinal hypotension in patients with severe preeclampsia and a non-reassuring fetal heart rate trace
… with increased fetal acidosis compared with phenylephrine. This has not been investigated prospectively in severe preeclampsia. Methods: Patients with severe preeclampsia requiring caesarean delivery for a non- reassuring fetal heart tracing were randomised to receive bolus ephedrine (7.5-15 …
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Adrenergic-cholinergic interactions in the heart
… IBMX, a phosphodiesterase inhibitor, and phenylephrine, an a-adrenoceptor agonist. While the inhibitory effect of carbacholon the isoproterenol-stimulated cAMP generation is believed to contribute to the negative inotropic effect of carbachol in the presence of isoproterenol, it is not …
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Comparação da midríase medicamentosa obtida em pacientes diabéticos tipo 2 sem neuropatia e não-diabéticos
… Evaluate and compare obtained mydriasis with phenylephrine 10% associated with tropicamide 1%, in type 2 diabetics and non-diabetic patients. Methods: A total of 60 patients (120 eyes) scheduled for fundoscopy were dilated with phenylephrine 10% and tropicamide 1% (group 0, n=30 type 2 …
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Cocaine- and Amphetamine-Regulated Transcript Peptide Attenuates Baroreflex in the Rat.
… in rats. Rats were intravenously administered phenylephrine every 10 min to elicit a baroreflex. CARTp (0.1- 3 nmol) by intracisternal or bilateral intra-NTS microinjection consistently attenuated the phenylephrineinduced bradycardia. In contrast, CARTp antibody potentiated the bradycardia …
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Haemodynamic consequences of Spinal Anaesthesia for non-emergency Caesarean section
… effects of the vasoactive agents ephedrine, phenylephrine and oxytocin during spinal anaesthesia for caesarean section in healthy patients and in patients with preeclampsia, and short term neonatal outcome after spinal anaesthesia in patients with severe preeclampsia. Research methodology …
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The regulation of protein synthesis in adult rat cardiomyocytes
… such as insulin and also by other agents such as phenylephrine (PE) that activates hypertrophy in the heart. Cardiac hypertrophy involves an increase in the muscle mass of the heart, principally in the left ventricular muscle, and the increase is due to enlarged cell size, not increased cell …
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The influence of body mass index on sensorimotor block and vasopressor requirement during spinal anaesthesia for elective caesarean section
… to ethyl chloride. The primary outcomes were phenylephrine requirement in the first thirty minutes following spinal anesthesia, and maximum block height, measured by the sensation of touch and cold. Secondary outcomes were total phenylephrine dose required, changes in hand grip strength, and …
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Sympathetic control of carotid body excitability in hypertension: A preclinical study
… body injections of α1-adrenoreceptors agonist (phenylephrine, 50 μL, 1 mM) in Wistar and antagonist (tamsulosin, 50 μL, 1 mM) in SH rats. Blind whole-cell patch-clamp recordings of chemoreceptive petrosal ganglion (PG) Neurones and in vivo radio-telemetric recordings were also carried out to …
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Effects of organophosphate esters on blood vessels: a physiological, pharmacological, and histological assessment of involvement in organophosphorus-induced delayed neuropathy (OPIDN)
… agonist, acetylcholine; the α1 agonist, phenylephrine; and the β2 agonist, salbutamol). These responses were compared before and 1, 3, 7, and 21 days after hens were administered cyclic phenyl saligenin phosphate (PSP, 2.5 mg/kg i.m.), an OP that induces OPIDN but does not significantly …
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Study on the effects of bitter taste receptor on the rat pulmonary artery
… rat pulmonary artery rings pre-contracted with phenylephrine or U46619 to study the pharmacological effect of bitter taste agonists as well as to investigate the possible mechanisms involved in their effects. The calcium fluorescence dye Cal-520 AM was used to measure the intracellular calcium …
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Altered Autonomic Nervous System Function in Chickens Divergently Selected for Body Weight
… rate and blood pressure after the injection of phenylephrine showed significant difference between these two lines of birds, but not when phenylephrine was injected following atropine. This result indicated that HWS are more dependent on the parasympathetic nervous system to regulate the …
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Effects of Senescence on Vascular Smooth Muscle in the Yellow Mud Turtle "Kinosternon flavescens" (Family "Kinosternidae")
… turtles were stimulated with potassium chloride, phenylephrine, acetylcholine, and isoproterenol to identify physiological responses in the vascular smooth muscle. No statistically significant changes in response related to aging were observed. Contractions were produced by acetylcholine, a …
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Aspects of the interrelation between hypertension and insulin resistance: A preliminary study
… future be used to study vascular reactivity to phenylephrine (PHE), acetylcholinc (AC!-1) and sodium ni troprusside (S~P) in hypertensive animals in the absence or presence of insulin resistance and in normotensive insulin resistant animals.
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Steps Towards a Closed-Loop System for Blood Pressure Control
… drugs. We use two actuators in our framework: phenylephrine, to raise blood pressure, and nicardipine, to lower blood pressure. We emphasize our use of the two-element Windkessel model in our pharmacodynamic component. We then build a model predictive control framework given this …
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