Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Pericardium"”.
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A description of the pharmacokinetics of first line anti-tuberculosis drugs and adjunctive corticosteroid therapy in the pericardial compartment and their effect on cytokine profiles in the pericardial compartment of patients with tuberculous pericarditis
… by Mycobacterium tuberculosis infection of the pericardium, which is associated with a higher mortality, compared with pulmonary tuberculosis. Constrictive pericarditis, a significant complication of tuberculous pericarditis, contributes to this elevated mortality. Adjunctive corticosteroid …
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A novel polymeric prosthetic heart valve: design, manufacture, and testing
… worse than expanded polytetrafluoroethylene and pericardium graft materials. In measures of inflammation, the BCPs and polytetrafluoroethylene were better than polyester and pericardium. A durable heparin coating gave SEPS22 superior haemocompatibility compared to all the reference materials. The …
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Immunological analysis of pericardial tuberculosis
… novel insight into the immune response in the pericardium to TB infection. Furthermore, HIV-1 infection caused a dysregulation of the immune response.
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Biomechanical structure-function relationships of collagen tissues, B Cell membranes, and amyloid fibers
… collagen tissues such as ligaments, tendons, and pericardium that serve as load bearing components in biological systems. A novel micromechanical model describing the force-extension of wavy fibers comprising these tissues is integrated with bundle and network frameworks. The developed models …
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Fully Coupled Fluid Structure Interaction Simulation of Bioprosthetic Heart Valves: A Numerical and Experimental Analysis
… Previous computational studies assumed (bovine pericardium) BP used in BHVs density was comparable to water or blood. Yet, BP is subjected to multiple treatments like fixation and anti-calcification. In Chapter 2, I measured BP density and its effect on BHV leaflet stress and strain. In the …
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Surgical techniques used for closure of perimembranous ventricular septal defects
… (n=71). Five patients in Group I had bovine pericardium used and 1 patient's VSD was closed by a direct suture technique. Group II consisted of 93 children operated on between 1995 to 1998, and had their VSDs closed with a 0.6% glutaraldehyde-treated autologous pericardial patch using 5.0 …
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The tetrapeptide Ac-SDKP and angiotensin converting enzyme in tuberculous pericarditis and fibrosis
… the metabolism of AcSDKP in the tuberculous pericardium. Ac-SDKP levels as measured by ELISA, were significantly decreased (2.3 fold) in TB pericardial fluid as compared to controls. This reduction in Ac-SDKP levels was accompanied by a local 28% increase in the enzymatic activity of ACE, but …
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Performance characteristics of the left ventricle during and following induced extrasystoles
… function of the heart in dogs with the chest and pericardium open, and under strictly controlled conditions. In spite of all the work j done in this field, there still exists some degree of confusion regarding the relative importance of autoregulatory mechanisms and extrinsic factors governing …
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Paravalvular sealing pf percutaneous heart valves
… (THV's) rely on sealing skirts made from treated pericardium or polyethylene terephthalate (PET) fabrics. The current study was aimed at developing novel electrospun skirts for the minimization of PVR in THV's. Thermoplastic polyurethane (TPU) was electrospun onto mandrels and several techniques …
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Cells of the Developing Human Heart and Great Vessels
… and the great vessels. Chapter 6 explores the pericardium and endocardium as the two layers enveloping the myocardium. Ultimately, through the profiling obtained from the atlas, Chapter 7 proposes a framework to generate enhanced stem cell models to mimic the corresponding cells *in vivo*.
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Reduction of Myocardial Stunning by in Situ Genetic Alteration of Myocytes
… heart. Therefore pMTSOD was injected into the pericardium with the expectation that cytoplasmic SOD levels would be elevated resulting in an increased resistance to reperfusion injury. Two days following intrapericardial injection of the plasmid, hearts were subjected to ischemia and …
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Fatigue life modelling of anisotropic styrenic block copolymers for a prosthetic heart valve application
… were significantly lower than on bovine pericardium, which is one of the materials used in clinical prosthesis. Durability of the calcified valve was not affected, indicating that the selected materials have great potential for biomedical applications. Finally, the effect of heparin …
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Investigating the pathways involved in the progression of fibrosis in tuberculous pericarditis
… (TBP) is a severe form of EPTB involving the pericardium that is present in 1-2% of TB cases, and poses diagnostic and therapeutic challenges, with mortality rates ranging between 8-34% despite anti- tuberculous therapy. TBP is the leading cause of pericardial constriction in Africa which is a …
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Investigating the role of macrophages in larval zebrafish heart regeneration
… macrophages to be recruited first from the pericardium and then the caudal haematopoietic tissue, preferentially using the abluminal wall of blood vessels to migrate to the site of injury. I next used macrophage-less irf8-/- larvae and metronidazole-nitroreductase macrophage ablation to test …
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Differently charged polypeptides and their impact on peritoneal and pleural postoperative adhesion formation
… Postoperative adhesions also form in pleura and pericardium after thoracic surgery. Complications include risk of bleeding, organ perforation and prolonged surgery, both in the thorax and abdomen, during reoperations. Previous reports have shown increased healthcare expenditures due to …
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Defining the Developmental Signals of the Cardiac Fibroblast
Cardiac fibroblasts play a central role as a mediator of inflammatory and fibrotic response and also secrete extracellular matrix components that provide structural support for regeneration and remodeling of the wound. Despite the importance of the cardiac fibroblast in heart disease, very little …
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Building a Methodological Framework for Cell Fate Engineering
Cell fate engineering has become an area of intense research in the last fifteen years. A useful framework of cell fate engineering should include three pillars: the discovery of new cell fate-reprogramming cocktails of factors, the evaluation of engineered cells, and the revelation of underlying …
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