Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Pax7"”.
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The developmental function of Pax7 : chromatin-immunoprecipitation discovery of Pax7 target genes
Pax7 plays critical roles in development of brain, spinal cord, neural crest and skeletal muscle. As a sequence-specific DNA-binding transcription factor, the direct functional role played by Pax7 during development is the selection of target genes. To date, an accurate description of the function …
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The role of PAX3/PAX7-FKHR in mesenchymal stem cell myogenic differentiation and rhabdomyosarcomagenesis
… t(1;13) translocations, involving PAX3-FKHR and PAX7-FKHR fusion genes respectively. These genetic events result in a molecular gain of function of the fusion protein, which is proposed to perturb the differentiation of muscle progenitor cells. Since PAX3/7-FKHR fusions result in rearrangements …
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An investigation of the mechanism of PAX7 mediated oncogenesis via in silico and in vitro biology
… of the Pax family, which includes Pax3 and Pax7, encode a second DNA binding domain of the paired-type homeodomain (HD) class. Pax3 and Pax7 are closely related paired box family members specifically expressed in the dorsal neural tube and the developing somites and in proliferating and …
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The role of <em>Pax7</em> in the formation of the superior colliculus and the vertebrate visual system
This thesis has explored the role of Pax7 in formation and maturation of the mouse superior colliculus, an important brain region associated with topographic visual input and the capacity to evoke appropriate visuomotor responses to environmental stimuli. The research performed was explicitly …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
… fibers. The paired box transcription factor 7 (Pax7) is the canonical biomarker for quiescent, activated, and proliferating satellite cells and is rapidly down-regulated upon differentiation into myofibers. However, the factors that regulate the modulation of Pax7 are largely unknown. …
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Strukturelle und funktionelle Untersuchung der Promotorregionen der menschlichen PAX3-, PAX6- und PAX7-Gene: Bedeutung von Polymorphismen für schizophrene Erkrankungen
… der menschlichen PAX3-, PAX6- und PAX7-Gene charakterisiert. Weiterhin wurden funktionelle Folgen der mit diesen Promotoren assoziierten Repeat-Polymorphismen auf die Expression dieser Gene untersucht. Schliesslich wurde die Relevanz für die psychischen Erkrankungen wie die …
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
… expression of the myogenic specification gene Pax7. Mll1 KO results in a minor decrease in Pax7 mRNA and a strong decrease of Pax7 protein. While MLL1 was found to bind the Pax7 promoter, Mll1 KO results in a minor decrease of H3K4me3 at Pax7, supporting a recognized non-HMT role for Mll1 at …
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The role of pax genes in vertebrate segmentation
… of processes in the developing embryo. Pax3 and Pax7 in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the paraxial …
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Role of Fra-2/AP-1 in Myogenic Progenitor Cells
… which harbor satellite cells. We observed Pax7 mRNA level went down accompanied with precocious differentiation upon konckdown of Fra-2, suggesting that Fra-2 may play a role in determining the fate of satellite cells by modifying the expression of the key specification factor, Pax7. In …
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The Role of Pax3 in Neuronal Differentiation of the Ophthalmic (OpV) Trigeminal Placode and Neural Tube during Chicken Embryonic Development
… differentiate. The precise role of Pax3 and Pax7 in the restriction and differentiation of dorsal interneuron progenitors has been difficult to assess due to the many additional factors involved in specification and patterning of the neural tube. We have used electroporation in the chick …
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
… significantly increases the formation of Pax7+ cells in engineered 3D skeletal muscle tissues (“myobundles”). Gene expression analysis suggested that within the myobundle environment the Pax7+ cells adopt a quiescent phenotype (3D SCs), characterized by increased Pax7 expression, cell …
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Functional Genomics Characterization of Six4 During Skeletal Myogenesis
… by expressing the transcription factor Pax7. Once activated, satellite cells repair the muscle damage and replenish the stem cell niche due to the coordinated function of several transcription factors including Pax7 and the myogenic regulatory factors (MRFs). MRFs are skeletal …
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Studying the Molecular Mechanisms for Generating Progenitor Cells during Tail Regeneration in Ambystoma mexicanum
… the neural tube. The transcription factors Msx1, Pax7 and Pax6 are expressed in their respective d/v domains in both the differentiated and the regenerating axolotl spinal cord. Furthermore, the secreted signaling molecule sonic hedgehog (Shh) is expressed in the floor plate in both the …
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The role of myostatin during postnatal myogenesis and sarcopenia
… the myoblast myogenic activity. An increase in a Pax7-only myoblast population from myostatin-null muscle indicated an enhanced satellite cell self-renewal process, consistent with the increased satellite cell number observed on the myostatin-null muscle fibres. Additionally, muscle regeneration …
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Expression and Putative Functions of Fibroblast Growth Factor 10 (Fgf10) in Developing and Adult Skeletal Muscles
… myofibers expresses Fgf10. Immunolabeling with Pax7 antibodies showed that a subpopulation of Fgf10-expressing myonuclei expresses this satellite stem cell marker. To delineate the function of Fgf10, I examined the limbs of newborn Pax3- Cre::Fgf10(flox/-) double transgenic mice, and I …
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Dissecting the Development and Function of C. elegans Glia with Mutations of the mls-2 and vab-3 Genes
… roles for the mls-2/Nkx/Hmx and vab-3/Pax6/Pax7 genes, respectively, in differentiation and expression of the genes hlh-17/Olig and ptr-10/Patched-related. Similar pathways regulate oligodendrocyte generation in vertebrate spinal cords. Using mls-2 and vab-3 mutants, as well as CEPsh …
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Perivascular cell contribution to skeletal muscle repair following physiological injury
… stem cells (MSCs; Sca-1+CD45-) accelerate Pax7+ satellite cell expansion and fiber repair during the initial stages of eccentric exercise training in mice. MSCs are a heterogeneous population of perivascular stromal cells, including but not limited to, pericytes, fibroadipogenic progenitor …
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The effects of furosemide on equine skeletal muscle satellite cell myogenesis and metabolism in vitro
… furosemide group compared to all other groups. Pax7 expression did not differ (P>0.05) between groups. Expression of the differentiation transcription factor myogenin, and embryonic sarcomeric myosin heavy chain decreased (P<0.05) when cells were treated with 100 µg/mL furosemide. Fusion index …
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Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity
PW1+/Pax7– skeletal muscle-derived interstitial progenitor cells (PICs) are myogenic in vitro, efficiently contribute to skeletal muscle regeneration in vivo, and are self-renewing in vivo whilst also giving rise to satellite cells (Mitchell et al. 2010). They have previously been identified in the …
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Serum-free media development using black soldier fly protein isolate and hydrolysate for cultivated meat
… the media composition. Immunostaining using Pax7 and DAPI identified supplemented media-maintained satellite cell identity of Bovine satellite cells, offering crucial insights into cellular proliferation. Furthermore, since each cell type requires varying serum and nutrients, testing these …
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