Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"Pausing"”.
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Regulation of Transcription Through RNA Polymerase II Promoter-Proximal Pausing
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Studies into Transcriptional Pausing Regulators and Drug Resistance in Mycobacterium Tuberculosis
… in the field, later steps like elongation, pausing, and termination remain underexplored. Here, we use structural, biochemical, and functional approaches to characterize later steps of the Mycobacterial transcription cycle. We aim to shed light on vulnerabilities within the cycle that may be …
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Measuring fluency: Temporal variables and pausing patterns in L2 English speech
<p>This paper examines temporal variables and pausing patterns in L2 English speech to investigate fluency as a measurable component of oral proficiency. Fluency can be defined as ‘speed and smoothness of oral delivery’. We can measure the speed of oral delivery through calculating temporal …
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The effects of speaking rate and pausing on comprehensibility of non-native English
… the temporal variables (i.e., speaking rate and pausing) on comprehensibility ratings of second language (L2) speech. Twenty advanced Chinese speakers of English were audio-recorded as they read 3 short airline flight announcement passages. For each passage, the speakers adjusted their speech …
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Control of Pausing in Rich-Lean Transitions by Spatially Localized and Spatially Diffuse Stimuli
… types of schedule-correlated stimuli on pausing in rich-lean transitions using rat subjects. Components had equivalent FR requirements and were each signaled by unique schedule-correlated stimuli. In one component, <em>rich, </em>satisfying the FR requirement produced 3 food pellets. In …
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Second Language Comprehension and Processing Grammatical Form: The Effects of Topic Familiarity, Mode, and Pausing
… mode (written input vs. aural input), and pausing affect comprehension and the ability of L2 learners of Spanish to process a new morphological form (the Spanish future tense) in the input. Two hundred sixty six participants in an accelerated beginning Spanish course were assigned to one of …
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The molecular mechanisms of transcription termination and pausing in the Escherichia coli threonine operon regulatory region
To study the mechanism of transcription termination at a rho-independent terminator, homoduplex and heteroduplex templates that contained mutations in the G + C-rich region of dyad symmetry in the Escherichia coli thr operon attenuator were constructed. Assays of these templates in an in vitro …
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Migratory Timescapes: Experiences of Pausing, Waiting, and Inhabiting the Meanwhile of Migrants and Asylum Seekers in Mexico
<p>Based on ethnographic fieldwork in Mexico´s southern border with Guatemala, this dissertation provides insights into contemporary experiences of migration in Mexico by engaging with the notions of movement, control, and settlement from a critical perspective. I explore these experiences through …
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Structural and biochemical characterization of RNA polymerase II transcription
… complex mechanisms. One such mechanism involves pausing of RNA polymerase II (Pol II) in the promoter-proximal region of genes. Pausing is stabilized by the protein complexes DRB-sensitivity inducing factor (DSIF) and negative elongation factor (NELF). Prior structural and biochemical studies …
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Moving Through Space, Pausing In Place: Vietnamese Doctoral Sojourners’ Transnational Experiences of Identity (Re)Negotiation, Sense of Belonging, and Sense of Home
For the past decades, an increasing number of international students have travelled overseas to study for their doctoral degrees. Vietnamese doctoral students have actively joined this international education-migration flow. As they are a highly mobile group, their sequential movement involves a …
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Abdominal-B Neurons Control Drosophila Virgin Female Receptivity
… We show that "slowing down" is actually pausing, rather than walking more slowly. Silencing Abd-B neurons decreased pausing but did not affect vaginal plate opening, demonstrating that these two aspects of female sexual behavior are functionally separable. Synthetic activation of Abd-B …
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Studies of the Molecular Mechanism of Attenuation in the Threonine Operon of Escherichia Coli Using Site-Directed Mutagenesis (Growth Dependent Expression, Translation, Ribosome Interference, Termination, Transcriptional Pausing)
Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
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AN INVESTIGATION OF THE MECHANISMS OF GROUCHO MEDIATED TRANSCRIPTIONAL REPRESSION
… repression by promoting Pol II promoter-proximal pausing. In this work, I took three different approaches to test this model, and gain understanding of Gro-mediated repression. For the first approach, genetic assays exploiting the GAL4/UAS system were used to drive the tissue-specific RNAi …
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c-Myc regulates transcriptional pause release and is a global amplifier of transcription
… transcriptional pause release. Transcriptional pausing occurs when additional regulatory steps are required to promote elongation of genes after transcription has initiated. Chapter 2 identifies transcriptional pausing as a general feature of transcription by RNA Pol II in mammalian cells. c-Myc …
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RNA G-quadruplexes and polyamines effects on translation: data analysis and development of software for ribosome pause prediction
… ribosomal frameshifting, decoding rate, ribosome pausing etc. The process of translation can be affected locally by the sequence of translated mRNA, e.g. by specific secondary structures as well as globally by cellular conditions, e.g. concentrations of metabolites such as polyamines. …
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The dissection of VEGFA stimulus-responsive regulatory and transcriptional changes in angiogenesis
… regulated by promoter-proximal RNA Polymerase II pausing and extend it to comprehensive analysis of gene expression and chromatin regulation by promoter-proximal pausing across cell types.
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Architecture and the Transitory Experience
… embodied in the act of travel, the act of pausing and resting is fundamental to fulfilling a biological need that arises from the exhaustion that accompanies continuous movement. The modern highway rest area was selected as this thesis project because of its nature as neither a permanent …
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Analysis of the Role of EIF5A in Mammalian Translation
… revealed not only evidence of enhanced ribosome pausing within coding sequences at elongation stall sites, but also an increase in non-canonical/sub-optimal translation initiation events in 5' UTRs in both yeast and human cells. These data lead us to formulate and test the hypothesis that …
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Transcriptional elongation defects enhance upstream poly (A) site utilization and SPT5 affects mRNA degradation through its physical and functional interaction with CCR4 -NOT complex
… defects cause increased transcriptional pausing or arrest that results in increased utilization of internal or upstream poly (A) sites. Transcriptional pausing/arrest can, therefore, be visualized in vivo if a gene contains internal poly (A) sites, allowing biochemical and genetic study …
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Morphogenetic Movements Contributing to Cell Aggregation in Dictyostelium Discoideum Wild-Type and Streamer F Mutants
… and shape change in situ referred to as pausing. These mutants, unlike wild-type, remain elongate and oriented with respect to the previous cAMP gradient for many minutes after stimulation. We infer that elevated cGMP causes pausing and maintains elongation and orientation. (d) We report …
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