Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 148 for “"Pathway Analysis"”.
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… approach was employed to determine the pathways that are activated upon cytokine challenge of adult human chondrocytes. We identified key regulatory kinases, p38, JNKI/2, ERKI/2, ERK5, JAK2, and STAT3 that were upregulated in phosphorylation as a result of inflammatory cytokine …
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Simple sequence repeat analysis and qualitative pathway analysis of Rathayibacter toxicus
… of R. toxicus were used for SSR discovery and analysis. Ten SSRs were selected based on common parameters and two were PCR-verified on all available strains for confirmation of the sequence data. Individual SSRs greatly varied across genomes and the results of different combinations of …
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Genetic Pathway Analysis of Abnormal Facial Development In Nonsyndromic Cleft Lip and Palate
… leaving a large knowledge gap. Following a pathway-based approach to identify NSCLP etiologic genes, this dissertation examined gene networks regulating facial morphogenesis. Three different pathways were assessed and found to have etiologic roles in NSCLP. The PBX pathway, implicated in …
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TRPV4 in the Choroid Plexus Epithelium: Pathway Analysis and Implications for Cerebrospinal Fluid Production
… chapters that follow describe components of the pathway by which TRPV4 is activated and ion flux is stimulated.
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A Tail-Based Test For Differential Expression Analysis and Pathway Analysis In Rna-Sequencing Data
… biomedical research for biomarker discovery and pathway analysis. Such data at the exon-level are usually heavily tailed and correlated. Conventional statistical tests based on the mean or median difference for differential expression likely suffer from low power when the between-group difference …
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Evaluation of Zinc Toxicity Using Neuronal Networks on Microelectrode Arrays: Response Quantification and Entry Pathway Analysis
… potential generation allowed a quantitative analysis of the temporal evolution of network spike activity generation at specific zinc acetate concentrations. Cultures responded with immediate concentration-dependent excitation lasting from 5 to 50 min, consisting of increased spiking and …
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Development of Models for the Action of Novel Anti-apoptotic Proteins using Gene Regulation, Pathway Analysis and Protein Structure Prediction
… tools to analyse the major genetic and metabolic pathways involved in ovarian and non-small-cell lung carcinoma (NSCLC). The study also sought to characterise the predicted structures of some of the key proteins that regulate these pathways and networks. The wider aim of the work was to use these …
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The impact of folate deficiency on the base excision repair pathway: Analysis of enzyme coordination in response to dna damage and imbalanced repair
<p>The condition of folate deficiency has been implicated in carcinogenesis, with the strongest evidence formulated in colon cancer. The role of folate in DNA repair, DNA synthesis and methylation reactions renders this nutrient an valuable target for studying the onset and progression of cancer. …
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Systems Biology Approaches For The Analysis Of High-Throughput Biological Data
… majority of life sciences experiments.</p> <p>Pathway analysis methods are used to interpret high-throughput biological data to identify such processes by incorporating information on biological systems to translate data into biological knowledge.</p> <p>Although widely used, current methods …
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Dimensionality Reduction, Feature Selection and Visualization of Biological Data
… to dimensionality reduction in genomic analysis and biomarker identification studies are: Feature extraction, creating new features by combining existing ones based on a mapping technique; and feature selection, choosing an optimal subset of all features based on an objective function. …
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IMPLEMENTAZIONE DI DUE METODI PATHWAY TOPOLOGY-BASED PER L’ANALISI DELLA PERTURBAZIONE DI PATHWAY BIOLOGICI
… la ricostruzione ad elevata risoluzione di pathway biologici e network di interazioni molecolari, le cui anomalie sottendono diverse malattie e disturbi fisiologici. In questo contesto, la biologia dei sistemi si pone come mezzo di facilitazione per la ricerca biomedica di base, aprendo …
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Elucidating the genetic aetiology of Bipolar Disorder
… Methods and Materials: This thesis describes the pathway analysis of whole-genome sequencing (WGS) data from four Afrikaner individuals to identify candidate variants for genotyping in a Family-Based Association Test (FBAT) of 621 individuals of Caucasian and Mixed Ancestry families from South …
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Exploring the complex relationships between pre-existing conditions (comorbidities) and cancer treatments and outcomes
… (CPRD and HES). Firstly, a quantitative analysis explored associations between comorbidity and the receipt of cancer treatments and health-care resource use. Then a pathway analysis mapped out the recommended treatment pathways from the guidelines and evaluated the impact of comorbidity …
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Analisi dei profili di espressione dei microRNA: identificazione di biomarker nel suicidio
… Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis to clarify the possible role of the identified miRNAs in biological mechanisms involved in suicide. Results from GO analysis indicated that miR-4286 and miR-186-5p regulate the expression of key genes involved in neuronal processes …
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Disturbo bipolare e cefalea a grappolo: identificazione di geni e pathway molecolari e loro potenziale coinvolgimento nella risposta alla terapia con sali di litio tramite analisi dei profili di espressione genome‐wide
… responders to lithium share common molecular pathways potentially involved in predisposing to positively respond to prophylactic lithium treatment. To this aim, we carried out a transcriptome study in lymphoblastoid cell lines from 10 BD type I patients, responders to lithium, 8 CH patients …
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Functional genomics in the stroke-prone spontaneously hypertensive rat: genome wide and candidate gene analysis
… s-transferse mu type 1 (Gstm1). Ingenuity pathway analysis of renal microarrays in 5 and 16-week SHRSP, normotensive Wistar Kyoto (WKY) and chromosome 2 congenic rats identified differential expression of several glutathione cycling genes. The Gstm1 promoter was investigated by luciferase …
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Application and Development of Molecular Dynamics Methods to Examine the Energy Landscapes of Protein Folding and Transient Protein -Protein Complexes
… of the reaction center revealed a probable exit pathway. Steered Molecular Dynamics was used to pull cyt c2 along the proposed pathway. Analysis of the non-bonded energies during the pull revealed reduction of attraction as the molecule moves toward the end of the reaction center. It was shown …
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Multi-omics Data Integration for Identifying Disease Specific Biological Pathways
Pathway analysis is an important task for gaining novel insights into the molecular architecture of many complex diseases. With the advancement of new sequencing technologies, a large amount of quantitative gene expression data have been continuously acquired. The springing up omics data sets such …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
… functions in a number of important molecular pathways in diverse immune cells. Both innate and adaptive immune cells contribute to pathogenesis of lupus. Among those cells, B cells play a central role in pathogenesis of lupus nephritis in an anti-body dependent manner through differentiation …
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Genetic and gene expression analysis of nasopharyngeal carcinoma (NPC)
… in diverse functional processes, while genetic analysis detected extensive genomic abnormalities including large and small, discrete regions of copy number change and loci that exhibit uniparental disomy (UPD). The relationship between chromosomal copy number and level of gene expression were …
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