Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"PVN"”.
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Neurons projecting to the paraventricular nucleus of the hypothalamus are activated and contribute to cardiorespiratory responses to systemic acute hypoxia
… neurons have wide projections, including to the PVN. The PVN has the ability to play a role in all facets of in cardiorespiratory and neuroendocrine responses to hypoxia. We therefore asked the overall question of how the PVN receives chemoreceptor information and what the functional significance …
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The Role of the Circadian Clock in the Paraventricular Nucleus of the Hypothalamus in Diurnal Energy Balance
… factor, BMAL1, in the paraventricular nucleus (PVN) of the hypothalamus has revealed its importance in driving rhythms in energy intake and metabolism, its transcriptional functions across time and in individual cell types in the PVN are not well understood. In this study, we show that loss of …
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Lesioning of the Nucleus of the Hippocampal Commissure Followed by Food Deprivation Stress in Birds Demonstrates Simultaneous Involvement in both the Hypothalamo-Pituitary-Adrenal Axis and the Hypothalamo-Pituitary-Thyroid Axis
… prior to the paraventricular nucleus (PVN), the major driving nucleus of the classic neuroendocrine HPA axis. The objective of this study was to perform a knock down of the NHpC via electrolytic lesioning, thus eliminating a significant portion of its population of CRH neurons. An …
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Neural mechanisms promoting G-alpha-i2 protein dependent salt sensitive hypertension in the Sprague-Dawley rat
… role of Hypothalamic Paraventricular Nucleus (PVN) Gαi2 proteins in the maintenance of salt resistance and normotension in the rat. Salt resistant rats such as the Sprague-Dawley (SD) rat site- specifically upregulate these proteins in response to elevated dietary sodium intake to facilitate …
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Neuromedin U Acts via the Paraventricular Nucleus of the Hypothalamus and the Dorsal Raphe Nucleus to Regulate Motivation for High-Fat Food
… the paraventricular nucleus of the hypothalamus (PVN), NMU has also been found in other brain regions involved in both feeding behavior and motivation. We investigate the effects of NMU on motivation for food and food intake, and identify the brain regions mediating these effects. The motivational …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… adult hypothalamic rat paraventricular nucleus (PVN).</p> <p>Given the clinical relevance of potential age-dependent differences in serotonergic signaling and regulation of hypothalamic function, the objective of the studies in this dissertation was to identify and characterize the mechanisms of …
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Neuroanatomical specificity of prolactin-induced hyperphagia and expression of fos-like immunoreactivity following central administration of prolactin
… the role of the paraventricular nucleus (PVN), ventromedial nucleus (VMH), and medial preoptic nucleus (MPOA) in the hyperphagic actions of PRL. Ad libitum fed virgin female rats received twice daily site-specific injections of PRL (800 ng) over a period of 10 days. Only subjects …
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Evidence for effects of phoenixin on neurons of the paraventricular nucleus
The paraventricular nucleus (PVN) of the hypothalamus has been implicated in autonomic regulation. Through projections to the pituitary gland, median eminence and hindbrain, the PVN plays a role in stress response and other autonomic functions. Recent findings have indicated that both phoenixin …
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NADPH-d staining in the supraoptic and paraventricular nuclei increases in late pregnant and lactating rats and is influenced by ovarian steroids and central oxytocin levels
… in the supraoptic (SON) and paraventricular (PVN) nuclei in late pregnancy. This work was extended to investigate whether increases in staining were evident at other times during pregnancy and lactation. The number of cells in the SON and PVN that stained for NADPH-d in rats on Day 4, 12, 16, …
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Role of Toll-Like Receptor 4 in Pathophysiology of Hypertension
… in the paraventricular nucleus of hypothalamus (PVN), particularly in the neurons and microglia but not so much in astrocytes. TLR4 blockade specifically in the PVN not only reduces PICs, NE and HMGB1 (an endogenous ligand for TLR4) but also improved anti-inflammatory cytokines within the PVN of …
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Neuroendocrine Consequences of Binge Alcohol Exposure During Peri-Puberty on Functioning of the Hypothalamo-Pituitary-Adrenal (HPA) Axis
… (AVP) localized in the paraventricular nucleus (PVN) of the hypothalamus are the major neuropeptides involved in modulating HPA axis responses to stress. Corticosterone (CORT) in rodents, and cortisol in humans, is a major glucocorticoid hormone released into the circulation upon activation of …
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Characterization of Tyrosine Hydroxylase-Positive Neurons Projections from the Paraventricular Nucleus of Hypothalamus to Hindbrain Autonomic Regulatory Centers
… in the paraventricular nucleus hypothalamus (PVN) to key parasympathetic and sympathetic premotor nuclei in medulla oblongata, including the nucleus tractus solitarius (NTS), dorsal motor nucleus of the vagus (DMV), and rostral ventrolateral medulla (RVLM), remains undefined. This study aims …
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Role of gamma-aminobutyric acid (GABA) in hypothalamic nuclear development
… nucleus (VMN), the paraventricular nucleus (PVN), and the arcuate nucleus (ARC). The VMN and PVN have a unique pattern of GABA expression in elements surrounding the nuclei, with a void of GABA within the region of the developing nuclei. The ARC, on the other hand, has dense GABAergic …
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Spectroscopic characterization and photochemistry of nitrogen-containing molecules relevant to Titan's atmosphere
… of (E)- and (Z)-phenylvinylnitrile ((E)- and (Z)-PVN, Ph-CH=CH-C≡N), structural isomers of the simplest polycyclic aromatic nitrogen heterocycle (PANH) quinoline, was also characterized. Both (E)- and (Z)-PVN were found to be planar in the ground and first excited electronic state. (E)-PVN was …
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Fasting alters histone methylation in paraventricular nucleus of chick through regulating of polycomb repressive complex 2
… period in chicks' paraventricular nucleus (PVN). In this study, we investigated the detailed mechanism behind changes in H3K27 methylation following fasting stress. After 24 hours fasting on 3 days-of-age (D3), chicks exhibited elevated mRNA levels of PRC2 key components, including EZH2, SUZ …
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Cytochrome P450 1B1 and 12/15 Lipoxygenase Interaction in Paraventricular Nucleus in Angiotensin II-induced Hypertension in Females
… 2-ME) and ALOX15 in the paraventricular nucleus (PVN) as a mechanism that protects against Ang II-induced hypertension and its associated pathogenesis in female mice. <strong>Methods:</strong> Experiments were conducted in intact and ovariectomized (OVX) wild type (WT), alox15 knockout (ALOX15KO) …
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Mechanisms of hypothalamic regulation of food intake in birds
… hypothalamus (LH), paraventricular nucleus (PVN), ventromedial hypothalamus (VMH), and arcuate nucleus (ARC), were collected 5 days later. Real-time PCR was used to measure the mRNA abundance of appetite-associated neuropeptides and receptors in each nucleus. The results showed that the two …
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Tumor necrosis factor induced oxidative stress in the central nervous system contributes to sympathoexcitation in heart failure
… neurons of the paraventricular nucleus (PVN) is explored through an array of selective animal models combined with novel technologies for sympathoexcitation and cardiovascular function assessment. The effect of the TNF blocker, pentoxyfylline, was investigated on the expression of the …
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Investigation of somatomotor-sympathetic brain circuit abnormalities in two rat models featuring inborn differences in emotional behavior
… the hypothalamic paraventricular nucleus (PVN), locus coeruleus (LC), and periaqueductal gray (PAG), are implicated in responses to stressful and emotionally salient stimuli. Based on this observation, it was hypothesized that these parallel descending circuits shape responses to diverse …
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Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression
… Specifically, the perivascular niche (PVN) of GBM has been shown to facilitate tumor cell invasion and harbor a subpopulation of cancer stem cells, which are implicated in tumorigenesis and disease recurrence. However, the mechanisms by which the PVN promotes disease progression are …
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