Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"PRMT1"”.
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Methylation of Egfr By Arginine Methyltransferase Prmt1 Enhances Egfr Signaling and Cetuximab Resistance
… domain by protein arginine methyltransferase 1 (PRMT1) upregulates its binding to EGF and subsequent receptor dimerization and signaling activation. Methylation-defective EGFR mutant reduced tumor growth in mouse orthotopic xenograft model. Importantly, increased EGFR methylation sustains its …
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Investigating The Role of Prmt1 and Arginine Methylation of Hsp70 In Human Pancreatic Cancer
<p>Protein arginine methyltransferase 1 (PRMT1) is the major arginine methyltransferase, which catalyzes the addition of one or two methyl groups to the arginine residues of its substrate proteins. The best-known substrate for PRMT1 is histone, while more and more non-histone proteins are now found …
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The Design, Synthesis and in vitro Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Degradation of Protein Arginine Methyltransferase 1
Protein arginine methyltransferase 1 (PRMT1) is a protein responsible for the asymmetric dimethylation of arginine. PRMT1 is upregulated in a wide range of cancers and the reduction of PRMT1 activity reduces cell proliferation and tumour growth in cell and animal models of cancer. A reduction in …
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Kinetic Characterization, Inhibition, and Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1
… The predominant member of the PRMT family is PRMT1, as it is responsible for approximately 85% of the arginine methylation in mammalian cells. Since PRMT1 exhibits type I activity, it is the primary producer of the competitive NOS inhibitor, ADMA. Recently, dysregulated PRMT1 activity has also …
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Bead Based Peptidyl Libraries for the Selective Recognition of Glycoproteins, Differentiation of Carcinogenic Cell Types, and Determination of Enzyme Substrate Specificity
… enzyme, protein arginine methyltransferase 1 (PRMT1) will be discussed. The dysregulation of the activity of this enzyme has been implicated in a number of diseases including cancer and heart disease, and determining the substrate specificity for PRMT1 is an important step towards the …
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An Investigation of Epigenetic Mechanisms Driving The Biology of Head and Neck Squamous Cell Carcinoma
… a functional relationship between p53 and PRMT1, an arginine methyltransferase, in which mutant forms of p53 upregulate PRMT1 and increase total levels of ADMA, PRMT1’s methylation product. Further, using TCGA data, I demonstrate patients expressing high levels of PRMT1 have significantly …
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Targeting Epigenetic Regulators For The Treatment of Diffuse Large B-Cell Lymphoma
… critical role for the arginine methyltransferase PRMT1 in the regulation of lymphoma growth and survival. Therefore, PRMT1 presents a novel and promising target for the treatment of this cancer type.</p>
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… of nine protein arginine methyltransferases (PRMT1-9), which are of three types (I, II, and III). The majority of Type I enzymes asymmetrically dimethylate Glycine- and Arginine-rich (GAR) motifs, except for PRMT4, which methylates Proline-, Glycine-, and Methionine-rich (PGM) motifs. The same …
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Effect of TIS21 on DNA Damage Repair Induced by Etoposide
… DNA damage pathway. Furthermore, TIS21 regulated PRMT1 activity and induced hypermethylation of Mre11 protein. In conclusion, TIS21 involved DNA damage signaling and inhibited Chk2-p53 pathway via Mre11 methylation.
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Characterizing The Recognition Motif and Novel Substrates of Carm1
… methylation motifs for three of these enzymes – PRMT1, Coactivator associated arginine methyltransferase 1 (CARM1) and PRMT9. The OPAL platform can also be used to gauge the subtle changes in substrate specificities due to mutations in the enzymes, which may be important in pathologies. In …
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The Mammalian Hypoxia Response Pathway: Regulation of HIF and HIF Prolyl Hydroxylases
… by Protein Arginine Methyltransferase 1 (PRMT1) in vitro. Inhibition of methyltransferases in vivo further stabilized and activated HIF-1alpha suggesting a role for methyltransferases in regulation of HIF that might be mediated through HPH enzymes. Methylation of HPH enzymes, the first …
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Metilación de histonas y fisura labio-palatina: asociación e interacción de variantes genéticas
… KDM1A, KDM6A, KDM6B, KMT2D, MECOM, PHF8, PRDM16, PRMT1, SETDB1, WHSC1) y el riesgo de FL/PNS en población chilena. La hipótesis planteó que variantes de estos genes representan elementos de riesgo para la aparición de fisuras labio/palatinas no sindrómicas. La metodología incluyó 249 casos con …
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DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS
… degradation of tumor suppressors such as PRMT1 and limiting cancer cell survival. Microscale thermophoresis (MST) experiments on the PNA ligand AATAAA revealed a dissociation constant in the low nanomolar range. For HMGB1, sequence optimization of the initial ATAG motif led to a twofold …
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Identifizierung und Charakterisierung von Histonmethyltransferasen in Drosophila melanogaster
… werden, die den Säugerproteinen CARM1, PRMT1 und PRMT3 homolog sind. Die cDNAs wurden klo-niert und die rekombinanten Proteine biochemisch charakterisiert. Während dieser Arbeit wurden von anderen Gruppen mehrere lysinspezifische Histon-methyltransferasen mit dem katalytisch aktiven …
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Quasivirus Infection Model Identifies a Novel Role for Protein Arginine Methyltransferase 1 in the HPV Lifecycle
… identify Protein Arginine Methyltransferase 1 (PRMT1) as a novel host factor required for persistent HPV18 infection. In addition, through transcriptomic analysis I found HPV18 does not drive its host keratinocyte to adopt the gene expression of an epithelial stem cell. Instead, it upregulates a …