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Showing 1 to 20 of 105 for “"PPAR"”.
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Endometrial Decidualization by TGF-β and PPAR-γ
… so we investigated the interaction of TGF-β and PPAR-γ on decidualization using cultured human endometrial stromal cell. METHODS: Human endometrial tissues were examined immunohistochemically for the expression of TGF-β receptors and transducer proteins in the TGF-β signaling. And we examined the …
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Refinement of the Docking Component of Virtual Screening for PPAR
… proliferator-activated receptor-gamma (PPAR") as a drug target holds applications for treating a wide variety of chronic inflammation-related diseases. Type 2 diabetes (T2D), which is a metabolic disease influenced by chronic inflammation, is quickly reaching epidemic proportions. …
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Discovery of botanical flavonoids as dual peroxisome proliforator, activated receptor (PPAR) ligands and functional characterization of a natural PPAR polymorphism that enhances interaction with nuclear compressor
Our data suggest that the PPARalpha/NCoR interaction is physiologically relevant, and can produce a discernable phenotype when the magnitude of the interaction is altered by a naturally occurring variation. Our detailed mechanistic study of the PPARalpha V227A variant allows for the design of …
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Functional genomic analysis of PPAR-gamma in human colorectal cancer cells
… of peroxisome-proliferator activated receptor (PPAR-gamma) is a member of the super family of nuclear hormone receptors and shows much promise as a chemopreventative and therapeutic target for colorectal cancer. Activation of PPAR-gamma by thiazolidinediones (TZDs) inhibits proliferation and …
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Defining Novel Clusters of PPAR gamma Partial Agonists for Virtual Screening
Peroxisome proliferator-activated receptor γ (PPARγ) is associated with a wide range of diseases, including type 2 diabetes mellitus (T2D). Thiazolidinediones (TZDs) are agonists of PPARγ which have an insulin sensitizing effect, and are therefore used as a treatment for T2D. However, TZDs cause …
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Mechanistic Studies Of A Novel Ppar-Gamma Mutant That Causes Lipodystrophy And Diabetes
<p>PPAR-gamma is a nuclear receptor that plays a central role in metabolic regulation by regulating extensive gene expression networks in adipose, liver, skeletal muscle and many other tissues. Human PPAR-gamma mutations are rare and cause a monogenetic form of severe type II diabetes with …
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Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
Peroxisome proliferator activated receptor gamma (PPARγ) is a ligand-modulated transcription factor belonging to the nuclear receptor superfamily. PPARγ regulates genes involved in adipocyte differentiation, insulin homeostasis, neuroprotection and anti-inflammation. As such, PPARγ is under …
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The Effects of PPAR-γ Activators on the Growth and Apoptosis of Melanocytes
… Peroxisome proliferator-activated receptors (PPARs) play an important role in cellular responses including proliferation and differentiation. It was reported that 3 subtypes of PPAR are expressed in human melanocytes and activators for PPAR-α and PPAR-γ modulates melanocyte growth and …
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Peroxisome Proliferator -Activated Receptor (Ppar)alpha Regulation of Highly Unsaturated Fatty Acid Synthesis
The aim of the subsequent study was to identify a PPARalpha ligand under EFA deficiency. Lysophospholipids (lysoPL) are the most likely candidates for the ligands because decreased HUFA under EFA deficiency may shift the equilibrium of phospholipid deacylation/reacylation cycle toward accumulation …
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Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust
… peroxisome proliferator activated receptor γ (PPARγ) nuclear receptor. To date, very few chemicals have been identified as possible PPAR ligands. In the thesis, our goal was to determine the PPARγ ligand binding potency and activation of several groups of major semi-volatile organic compounds …
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Regulation of Phosphorylation of PPARγ by CDK5 in Obesity
PPAR? is the receptor for thiazolidinedione (TZD) anti-diabetes drugs, and a key regulator of adipose differentiation and insulin sensitivity. Increased heart failure associated with specific TZDs has reduced their clinical use. However recent work suggested that phosphorylation of PPAR? at Ser273 …
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Defining the metabolic effect of peroxisome proliferator-activated receptor δ activation
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand activated transcription factors. There are three identified isotypes: PPAR alpha, PPAR gamma and PPAR delta, together controlling the expression of genes involved in inflammation, cell differentiation, …
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Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: Importance of peroxisome proliferator-activated receptor γ expression
… peroxisome proliferator-activated receptor γ (PPAR-γ) in intestinal epithelial and immune cells. Dietary spingomyelin decreased colonic inflammation in mice of both genotypes but more efficiently in mice expressing PPAR-γ. Using a real-time polymerase chain reaction array, we detected an …
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Intracellular signalling by arachidonic acid metabolites
… peroxisome proliferator activated receptor (PPAR)-γ, the activities of PPARs were assessed using JEG3 cells transfected with a PPAR-response element reporter construct (pTK-PPREx3-luc). The PPAR-γ-specific ligand, rosiglitazone, induced PPRE mediated activity in a concentration-dependent …
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Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring
… the peroxisome proliferator activated receptors (PPARs) and their target genes; acyl-coA oxidase (AOX), carnitine palmitoyl transferase-1 (CPT-1) and lipoprotein lipase (LPL).<br/><br/>Real time PCR indicated that the expression of several key genes involved in energy balance, including PPAR?, …
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Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
Peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and …
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A Study on the Effect of Peroxisome Proliferator-Activated Receptors (PPARs) Activation in Cultured Rat Brain Glial Cells
"The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which were originally known to be involved in the regulation of lipid and glucose homeostasis. Recently, there has been increasing reports on the involvement of PPARs during inflammatory process, but the exact …
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Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
… via Peroxisome Proliferator-Activated Receptor (PPAR)-γ in inflammatory disorders such as Crohn's Disease and Inflammatory Bowel Disease. We sought to determine whether CLA isomers would reduce inflammation via PPAR-γ in cultured mesangial cells, and in murine models of anti-glomerular basement …
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