Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"PIAS1"”.
-
Characterizing PIAS1 Function During Embryogenesis and Lung Cancer Progression
… E3 ligase protein inhibitor of activated STAT-1 (PIAS1) is one the few known SUMO conjugating enzymes known to date. PIAS1 was first discovered as a negative regulator of signal transducer and activator of transcription 1 (STAT-1), from which its name is derived. PIAS1 facilitates STAT-1 …
-
Innate immune modulation and pathogenic basis for porcine reproductive and respiratory syndrome virus
… The protein inhibitor of activated STAT1 (PIAS1) was identified as a molecular partner of N. PIAS1 binds to RelA (p65) and prevents NF-kB activation by interfering p65-DNA binding in the nucleus and thus functions as a negative regulator of NF-kB. The binding domain of PIAS1 was mapped to …
-
Sumo and Ubiquitin Ligases Regulate Hepatocyte Nuclear Factor - 1 Beta Transcriptional Activity
… The SUMO E2 ligase, Ubc9, SUMO E3 ligases, PIAS1 and PIASgamma , and the ubiquitin E3 ligase, Arkadia, were isolated as putative interacting proteins. SUMOylation of transcription factors affects their subcellular localization, intracellular transport, stability, and transcriptional …
-
Characterizing the RanGAP1-RanBP2 complex in mitosis
… (Topo II alpha, TACC2, CKAP-5, Plk1, USP7, PIAS1). Die meisten davon konnten entweder in vitro mit rekombinanten Faktoren (TACC2, Plk1) oder als endogene Proteine, die mit mitotischem RanGAP1-RanBP2 Komplex als Quelle der Sumo E3 Ligase-Aktivität assoziiert waren (TopoII alpha, Plk1, USP7), …
-
N-linked glycosylation of ether á go-go potassium channels: effects on cell surface expression and functional properties
… Natriumkanälen auftritt. Zusätzlich wurde PIAS1 als positiver hEag1 Interaktionspartner des C-terminalen hEag1 durch zwei unabhängige Yeast-Two-Hybrid Screens identifiziert. PIAS1 wird im Zellkernen exprimiert, wo es als Inhibitor der STAT-vermittelten Genaktivierung agiert. Die Hypothese, …
-
Identification and functional characterization of the novel MAR-binding protein, SATB2
… is specifically augmented by the SUMO E3 ligase PIAS1. Mutation of the sumoylation sites enhances the association of SATB2 with the immunoglobulin MARs, as well as its transactivation potential. Moreover, covalent attachment of SUMO1 and SUMO3 represses SATB2- dependent transcription, without …