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Showing 1 to 20 of 185 for “"PI3K/Akt"”.

  1. Modulation of Pi3K-Akt Pathway In Colorectal Cancer

    Nusrat, Maliha, <p>https://orcid.org/0000-0002-0417-0416</p>2021

    <p>The phosphatidylinositol-3-kinase (PI3K) signaling pathway is activated in 20-40% colorectal cancers (CRC) through PTEN loss (PTEN<sup>loss</sup>) and <em>PIK3CA</em> mutations (<em>PIK3CA</em><sup>mut</sup>). Allosteric AKT inhibition with MK2206 monotherapy has been ineffective in CRC …

    uthsc Repository record

  2. Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway

    Hutz, Janna2013

    … to dysfunctional cell signaling. The PI3K/AKT/mTOR pathway is an important pro-growth intracellular signaling cascade that is often inappropriately activated in a wide array of cancers. Efforts to develop anticancer drugs have therefore focused, in part, on identifying PI3K/AKT/mTOR …

    wustl Repository record

  3. Evaluation of the PI3K/Akt/mTOR pathway in Multiple Sclerosis

    MAMMANA, SANTAUniversità degli studi di Catania2017

    Background The PI3K/AKT/mTOR pathway is an intracellular signaling pathway that regulates cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/AKT/mTOR pathway may result in an enhanced susceptibility to autoimmunity. Aim of our …

    catania Repository record

  4. PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy

    Lindsey Nicole JacksonThe University of Texas Medical Branch2008

    … remnant liver. Phosphatidylinositol 3-kinase (PI3K), composed of a p85ƒÑ regulatory and a p110ƒÑ catalytic subunit, participates in multiple cellular processes, including cell growth and survival; however, the role of PI3K in liver regeneration has not been clearly delineated. In these studies, …

    utmb Repository record

  5. Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway

    Titilope Adenike IsholaThe University of Texas Medical Branch2008

    … Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, a crucial regulator of cell survival, is associated with poor outcome in neuroblastomas and our lab¡¦s previous work has shown that GRPR regulates the expression of PI3K/Akt pathway components. However, the signaling mechanisms …

    utmb Repository record

  6. SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer

    Tovell, HannahUniversity of Dundee2020

    The PI3K-Akt signalling pathway is central to cell proliferation and growth, and hyperactivating mutations in this pathway are found in a large number of cancers. Downstream of PI3K, Akt is heavily studied, however the highly related SGK family of protein kinases have recently been identified as …

    dundee Repository record

  7. Estudio de la ruta de señalización celular de PI3K-AKT-mTOR en los carcinomas epidermoides nasosinusales

    Muñoz Cordero, María Gabriela2018

    … (CENS) son tumores de mal pronóstico. La ruta de PI3K/AKT/mTOR es la vía oncogénica mutada más frecuente en carcinomas escamosos de cabeza y cuello (CECC). El papel de la vía PI3K/AKT/mTOR y su implicación clínica y pronóstica en CENS todavía no ha sido investigada. El objetivo de este estudio fue …

    oviedo Repository record

  8. Dual Inhibition of the PI3K/Akt and MEK5/ERK5 Pathways for the Treatment of Breast Cancer

    Wright, Thomas Douglas2020

    … aberrations in the Phosphoinositide-3-kinase (PI3K) and Mitogen Activated Protein Kinase (MAPK) pathways have been linked to increased breast cancer proliferation and survival. It has been proposed that these survival characteristics are enhanced through compensatory signaling and crosstalk …

    duquesne Repository record

  9. The role of VEGF-induced PI3K/Akt signalling pathway in head and neck cancer cell migration

    Islam, Mohammad RafiqulUniversity of Dundee2015

    The PI3K-Akt signalling pathway is a well-established driver of cancer progression. One key process promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it has been shown that …

    dundee Repository record

  10. The adaptor protein p130Cas controls pancreatic acinar cell plasticity and cancer initiation through regulation of PI3K-AKT pathway

    Martini, Miriam, Costamagna, AndreaUniversità degli Studi di Torino2021

    unito Repository record

  11. An Investigation of the Role of Insulin Deficiency and Loss of PI3K-Akt Signaling Downstream Regulators GSK3β -CREB Signaling in the Pathogenesis of the Diabetic Brain

    ALRAZI, TAZRINAGraduate Studies2014

    … is speculated to act through activation of PI3K-Akt signaling. We hypothesized that the neurodegenerative changes and cognitive impairments observed in the chronic type 1 DM brain occur through impaired insulin-mediated phosphorylation of CREB/GSK3β, critical neuronal signals downstream of …

    calgary Repository record

  12. The mechanism of ovarian cancer chemoresistance

    Deng, JunliUNSW, Sydney2018

    … (EMT), cancer stem cells (CSC), as well as the PI3K/Akt/mTOR signalling pathway in OC chemoresistance, and provides a range of potential candidate chemoresistant biomarkers with proteomic technologies. The aims of this study were to: 1) compare the expression differences of EMT, CSC and …

    unsw Repository record

  13. Induction of death in myeloid leukaemia cells by doxorubicin and betulinic acid, singly and in combination was associated with the regulation of apoptosis, autophagy and the PI3K/Akt pathways

    Vu, M.Middlesex University2020

    … in apoptotic, autophagy and cell-survival (PI3K-AKT) pathways were examined by Western blot and reverse transcription polymerase chain reaction (RT- PCR) analysis, respectively. Dox showed non-discriminatory inhibition of cell viability (p < 0.05) in all tested cell lines including …

    middlesex Repository record

  14. Long-Term Hypoxia Alters Ovine Fetal Adrenal eNOS and Cortisol Biosynthesis

    Newby, Elizabeth Anne

    … In examining the effects of the MEK/ERK1/2, PI3K/Akt, and calcium signaling pathways, we found that the MEK/ERK1/2 pathway and calcium do not regulate eNOS phosphorylation (peNOS), but the PI3K/Akt pathway, along with ACTH, regulates peNOS in LTH fetal adrenocortical cells (FACs); inhibition …

    loma-linda Repository record

  15. Gsk3 Mediates Signaling Upstream of Akt

    Smith, Debra L2010

    The phosphatidylinositide 3 kinase (PI3K)/Akt signaling network plays a pivotal role in multiple cellular functions. PI3K links the extracellular growth factor receptors to the serine-threonine kinase Akt which, through phosphorylation of numerous intracellular proteins, mediates increased cell …

    uthsc Repository record

  16. Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis

    Goertz, Meredith Johanna2013

    … Foxo3 and Foxo4. Conditional inactivation of PI3K/Akt pathway components in the male germ line confirmed that PI3K signaling regulates Foxo1 stability and subcellular localization, revealing that the Foxos are crucial effectors of PI3K/Akt signaling in SSCs. The nuclear localization of Foxo1, …

    utswmed Repository record

  17. Mechanismen der Urocortin-II-induzierten Stimulation der NO-Produktion in isolierten Kaninchen-Ventrikelmyozyten

    Walther, Stefanie2012

    … ein Peptid aus der Corticotropin-Freisetzungs-Faktor (CRF) Familie. UcnII verbessert die Herzfunktion im Gesunden und in der Herzinsuffizienz. In Kardiomyozyten ruft UcnII ein cAMP und Ca2+-abhängigen positiv Inotropen und Lusitropen Effekt hervor. Ziel dieser Studie war es die …

    goettingen Repository record

  18. Small Molecule Regulator of ENTPD5, and ER Enzyme in the PTEN/AKT Pathway

    Huang, Song2011

    PI3K signaling plays a crucial role in effecting alterations in a broad range of cellular functions in response to diverse extracellular stimuli (insulin, growth factors, integrins and GPCRs etc.). A key downstream effector of PI3K is the serine-threonine kinase Akt, which in response to PI3K …

    utswmed Repository record

  19. Protektiver Effekt von 6-Shogaol, Ellagsäure und Myrrhe auf die intestinale epitheliale Barriere

    Lüttig, JuliaUniversität Potsdam

    Viele bioaktive Pflanzeninhaltsstoffe bzw. Pflanzenmetabolite besitzen antiinflammatorische Eigenschaften. Diese versprechen ein hohes Potential für den Einsatz in der Phytotherapie bzw. Prävention von chronisch-entzündlichen Darmerkrankungen (CED). Eine intestinale Barrieredysfunktion ist ein …

    potsdam-diss Repository record

  20. 1á,25(OH)2-VITAMIN D3 IN PROSTATE: INTERSECTION WITH AKT/PTEN AXIS AND ROLE IN SENESCENCE

    Axanova, LinaraWake Forest University2010

    The PI3K-AKT pathway is frequently activated in prostate cancer and can lead to downregulation of p21 and p27 levels and function. 1-alpha, 25-dihydroxy vitamin D<sub>3</sub> (1á,25(OH)<sub>2</sub>D<sub>3</sub>) inhibits proliferation of multiple cancer cell types, including prostate cancer cells, …

    wfu Repository record

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