Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"PAR-2"”.
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Molecular regulation of glioma cell migration: assessment and therapeutic implications
… emerging evidence indicates that the CD142/PAR-2 cascade is implicated in glioblastoma proliferation, invasion and migration. Recent data suggest that CD142 play a crucial oncogenic role in various tumours via the PAR-2 pathway which is capable of modulating the ERK cascade through ARR1. …
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Characterisation of protease activated receptors
… receptor as an antigen. An affinity matrix prepared from one monoclonal antibody was used in the successful purification of the native receptor from human platelet membranes. Two of the monoclonal antibodies were capable of blocking thrombin-induced platelet aggregation, and this may lead to …
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The role of elastase as an inflammatory stimulus in chronic obstructive pulmonary disease
… proteinase/anti-proteinase balance. This is of particular importance in emphysema where increases in neutrophil elastase concentration results in the destruction of elastin fibres which results in a decrease in lung function. Elastase is also known to contribute to the mucus hypersecretion …
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Le forme del lavoro associato con particolare riguardo all'associazione in partecipazione
… deal with the contract of �associazione in partecipazione� labour intensive. In the second chapter, this contract is analysed as it was originally provided by the Civil Code, with references to the relevant jurisprudence. In the third chapter, the thesis stresses the most outstanding …
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Role of mast cells in women's health and disorders of the endometrium
… has well defined stromal and epithelial compartments with the former containing both a well-developed vasculature as well as a diverse population of immune cells. Mast cells (MCs) are long-lived tissue resident immune cells characterised by the presence of granules containing proteases. Mast …
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Factors influencing the development of protective and pathological responses to Trichinella spiralis infection
… shown that signalling via the novel receptor PAR-2 plays a role in the development of enteropathy but not in the expulsion of T. spiralis, and was not required for the development of mucosal mastocytosis but enhanced mast cell degranulation. Thus, in conclusion this thesis provides further …
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ΔΙΚΟΝΟΜΙΚΗ ΑΚΥΡΟΤΗΤΑ. Η ΑΚΥΡΟΤΗΤΑ ΤΩΝ ΔΙΑΔΙΚΑΣΤΙΚΩΝ ΠΡΑΞΕΩΝ ΚΑΙ Η ΘΕΡΑΠΕΙΑ ΤΗΣ ΚΑΤΑ ΤΑ ΑΡΘΡΑ 159 ΕΠ.ΚΠΟΛΔ
… INCLUDED IN THE ABOVE GENERAL PROBLEMATIC. THE PAR. 159-161 GR.CIVIL PROCEDURE CODE INTRODUCE EXTEND POSSIBILITIES TO REMEDY THE PROCEDURAL INVALIDITY. ESPECIALLY IMPORTANT IN THIS CONTEXT IS THE "DAMAGE PRINCIPAL", INTRODUCED BY PAR. 159.3 OFTHE GR.CIVIL PROCEDURE LAW. THE DISSERTATION PRESENTS …
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Channel activating proteases: molecular targets for correction of sodium channel dysfunction in cystic fibrosis airways disease
… their effect on inflammatory signaling via PAR-2 and also on ENaC activity in CF airway epithelial cells (AECs). Further, two highly selective and potent furin inhibitors, BOS-981 and BOS-318 were characterised, with the aim of determining whether selective inhibition of furin has the …
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Il contrasto dell immigrazione irregolare tra vincoli europei e politiche nazionali: un indagine comparata della disciplina italiana e francese
… politica europea in materia di immigrazione, con particolare riguardo alla problematica dell immigrazione clandestina, alla luce del nuovo quadro istituzionale offerto dal Trattato di Lisbona, che dovrebbe favorire un approccio congiunto, basato sulla fiducia reciproca e sulla solidarietà tra gli …
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Rho GTPase family members in establishment of polarity in C. elegans embryos
… polarity requires the evolutionarily conserved partitioning-defective (PAR) proteins as well as the actin cytoskeleton. In Caenorhabditis elegans one-cell embryos, the PAR proteins are segregated into an anterior (PAR-3, PAR-6) and a posterior (PAR-1, PAR-2) corticaldomain. The formation of PAR …
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Impacts de la modélisation stochastique des apports sur la gestion des ressources hydriques du système de la Romaine
… la Romaine est constitué de quatre réservoirs et parcourt une distance de 192 km entre la centrale Romaine-4 et le Saint-Laurent pour une chute totale de 459 mètres. Pour des fins de modélisation, le réservoir Romaine-1 est considéré comme au fil de l'eau vu son faible volume. Une fois complété en …
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IL CONTROLLO GIURISDIZIONALE DELLE MISURE DI APPLICAZIONE DEL DIRITTO DELL'UNIONE EUROPEA
… indiretta del diritto dell’Unione da parte degli Stati membri e (rari) casi di amministrazione diretta da parte dell’Unione (cfr. art. 291, par. 2 TFUE e art. 4, par. 3 TUE). In tempi più recenti, tuttavia, la comparsa di nuove forme organizzative (si pensi, in primo luogo, …
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Educare alla cittadinanza democratica. La partecipazione di adolescenti e giovani negli enti locali della regione Emilia Romagna
… tesi sono i seguenti: • la crisi del ruolo dei partiti politici in Italia e in Europa: diminuiscono gli iscritti e la capacità di dare corpo a proposte politiche credibili che provengano dalla “base”dei partiti; • la crisi del sistema formativo1 in Italia e il fatto che l’educazione alla …