Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"PAPS"”.
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… patients with primary antiphospholipid syndrome (PAPS). Anti-2GPI activate endothelial cells (EC) resulting in a pro-thrombotic and pro-inflammatory phenotype. In order to characterise EC gene regulation in response to anti-2GPI, early global gene expression was assessed in human umbilical vein …
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Psychotherapists' beliefs and attitudes towards polyamory
… Attitudes towards Polyamory Scale (PAPS), which measures psychotherapists’ beliefs about the health or pathology of polyamory, problems presumed to be associated with polyamory, beliefs about treatment, and personal bias. Additionally, psychotherapists’ awareness of polyamory was …
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Poly(A) Polymerase 1 (PAPS1) influences organ size and pathogen response in Arabidopsis thaliana
… by canonical nuclear poly(A) polymerase (PAPS). Both vertebrate and higher-plant genomes encode more than one isoform of this enzyme, and these are coexpressed in different tissues. However, in neither case is it known whether the isoforms fulfill different functions or polyadenylate …
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Dehydroepiandrosterone and dehydroepiandrosterone sulphotransferase activity and expression in human disease
… requires 3'-phosphoadenosine-5'-phosphosulfate (PAPS) for catalytic activity. I have identified compound heterozygous mutations in the gene encoding human PAPS synthase 2 (PAPSS2) in a girl with androgen excess and confirmed the inactivating nature of the mutations via in vitro activity analysis. …
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BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex
… cleft. Increasing evidence demonstrates that PAPs are critical for synapse formation, stabilization, and plasticity. However, the mechanisms that govern the formation of tripartite synapses remain to be fully elucidated. This dissertation investigates the role of the astrocyte TrkB.T1 …
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Enzymatic Sulfurylation Mechanisms
… 3'-phosphoadenoslne 5'-phosphosulfate (PAPS<sup>35</sup>) into lipid-soluble material has been investigated in cell-free preparations of rat brain and liver. In brain of 10-20 day old rats activity was found in the particulate fraction of the homogenate, whereas in young adult rat liver …
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Ecocardiografía de esfuerzo y determinación de péptidos natriuréticos para la detección precoz de hipertensión arterial pulmonar en pacientes con esclerodermia
… de la presión arterial pulmonar sistólica (PAPs) al esfuerzo medida por ecocardiografía y los valores del péptido natriurético plasmático (NT-proBNP) permiten predecir el desarrollo futuro de Hipertensión arterial pulmonar (HAP) de una forma precoz en pacientes con esclerosis sistémica (ES). …
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Molecular cloning and characterization of two Arabidopsis thaliana sulfotransferases
… enzymes contain all the amino acids involved in PAPS binding and catalysis (Marsolais et al. 1995). Expression studies failed to determine conditions under which the genes preferentially expressed. Putative transgenic plants constitutively expressing AtST4a in the sense orientation produced a …
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The Effect Of Hyperparameters In The Activation Layers Of Deep Neural Networks
… pools (APs) and parametric activation pools (PAPs), and study the effectiveness of these new constructs on popular image recognition datasets.
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Structure and Mechanism of a Eukaryotic FMN Adenylyltransferase
… reveals that eukaryotic FMNAT is related to the PAPS reductase-like family, which belongs to the adenine nucleotide α hydrolase-like superfamily. Despite the classification of eukaryotic FMNAT, the residues involved in substrate binding and catalysis are not completely known, as eukaryotic FMNAT …
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Global Airway Management of the Unstable Cervical Spine Survey
… networks to physician anaesthesia providers (PAPs). Global and regional trends were assessed using descriptive statistics. Results Of a total of 1904 responses, 1153 (101 countries) were included in the final analysis. In the emergency case, 46.9% (95% confidence interval [CI]: 44.0–49.8%) of …
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Isolation and Characterization of Soybean Genes Involved in Phytic Acid Metabolism: Phytase and 1-L-myo-Inositol-1-Phosphate Synthase
… similarity to plant purple acid phosphatases (PAPs) and contained the conserved metallo-phosphomonoesterase active site motif. The soybean phytase coding sequence was placed under the control of a constitutive 35S CaMV promoter in a soybean biolistic transformation vector and was introduced …
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Tyrosine Sulfation in A431 Cells
… peptide was 0.12 mM, and for the sulfate donor, PAPS, was 0.45 uM. In addition, I also examined the tyrosine sulfotransferase activities from rat liver RER and Golgi fractions with the C4 peptide.
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Functional specialization of Arabidopsis poly(A) polymerases in relation to flowering time and stress
… copies of canonical poly(A) polymerases (cPAPs). The disruption of cPAPs in mammals results in lethality. In plants, reduced cPAP activity is non-lethal. Arabidopsis encodes three nuclear cPAPs, PAPS1, PAPS2 and PAPS4, which are constitutively expressed throughout the plant. Recently, the …
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Leveraging <i>Borrelia burgdorferi</i> peptidoglycan chemistry to understand Lyme disease symptom progression
… binding of peptidoglycan associated proteins (PAPs), particularly P83/100. P83/100 was previously shown to drastically affect bacterial burden in a murine model, and using immunofluorescence, we established that our mutant strain exhibits low abundance of this protein. With this as impetus, we …