Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"PAMs"”.
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The development and characterization of soft robotic contractile actuators
… myocardium and pneumatic artificial muscles (PAMs) that replicate the physiological motion of the heart. We were able to generate physiological twisting motion in a confined geometry, but additional actuators would be required to generate physiological force for blood ejection. However, …
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Competencies and physical agent modalities: An investigation of clinical and ethical implications
… incorporated physical agent modalities (PAMs) into the treatment process. Throughout this process there has been both opposition and support for the inclusion of PAMs in occupational therapy. There are concerns from both sides regarding the proper training of therapists in the use of …
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A computer-simulation-based molecular-thermodynamic model for shape-based screening of peptide amphiphile micelles in vaccines
… aggregates, peptide amphiphile micelles (PAMs), have garnered considerable attention as a platform for biomedical applications due to their unique combination of biocompatibility, modular functionality, and tailorable size and shape. Since PAMs form a wide range of structures (e.g., …
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Synthesis of phenylacetylene macrocycles and macrobicycles and their organization in solution, at the air-water interface and on solid surfaces
… cyclized to give phenylacetylene macrocyclic (PAMs) and macrobicyclic compounds (BIPAMs) in high yields. Amphiphilic compounds were obtained by performing simple transformation of the functional groups on these PAMs and BIPAMs.
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The Exploration of KNN-based Neural Control of Pneumatically Actuated Artificial Muscle
… in the form of Pneumatic Artificial Muscles (PAMs). KNN classification is a lightweight non-parametric learning algorithm that can rapidly identify and sort an input into pre-determined categories given initial training data sets. In this thesis, I present a method of using KNN classification …
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Effect of penicillin G on the reproduction of Salmonella cholerasuis in the presence and absence of porcine alveolar macrophages in a pharmacodynamic model
… chambers containing the drug. The addition of PAMs did not produce a significant decrease in the number of viable bacteria in the chamber when compared to a chamber with no PAMs. The comparison to determine if penicillin and PAMs acted synergistically in reducing the numbers of Salmonella …
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Polyacrylamide and its derivatives for oil recovery
… suspension system was developed to synthesize PAMs and PAMs-microgel. Products are dry particle powder and ready to disperse in water. Compared to traditional methods, less surfactant was consumed, and the required energy cost post-treatments, like drying, were not necessary. Hydrophobically …
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Rarely Acquired Type II-A CRISPR-Cas Spacers Mediate Anti-Viral Immunity Through the Targeting of a Non-Canonical PAM Sequence
… infection target protospacers flanked by N-G-G PAMs. As a consequence, the great majority of acquired spacers target such sequences. However, there is a small fraction of acquired spacers that target non- canonical PAMs. Whether these "non-canonical" spacers originate through accidental …
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Soft pneumatic artificial muscles with low threshold pressures for a cardiac compression device
… of fully soft pneumatic artificial muscles (PAMs) with low threshold pressures that are intended for direct cardiac compression (DCC). McKibben type PAMs typically have a threshold pressure of at least lOOkPa and require rigid end fittings which may damage soft tissue and cause local stress …
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Mechanistic insight on a chimeric Cas9 protein's specificity for DNA target with 5 '-NAA-3' PAM
… that can recognize protospacer-adjacent motifs (PAMs) other than the canonical NGG discovered in wild-type Streptococcus pyogenes. While Cas nuclease engineering has largely yielded proteins with enhanced specificity for NGG and variations on G-containing PAMs, we were able to construct a …
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Organotellurium Reagents for Multiparametric Interrogation of Dynamic Biology
Population-averaged measurements (PAMs) of cells have advanced understanding of innumerable biochemical processes and continue to be routinely used in the laboratory. Despite this success, PAMs are limited in their ability to report on the precise state of important individual members of a …
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Examining the Roles of GABAA Receptor Subtypes in Anxiety and Anxiolysis: Focusing on the Basolateral Amygdala
… positive allosteric modulators (PAMs) both in wild type mice and in mutant mice that express BZ-insensitive GABA<sub>A</sub>Rs of specific <em>α-subtypes</em>.</p> <p>In our experiments, systemic injections of the<em> <em>α1</em>-<em>selective PAM zolpidem</em> </em>in WT mice …
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Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
… GAT211 as CB1R-positive allosteric modulators (PAMs)5,6. In the second part of this project, we embarked on modifying structural features of GAT211. Biological assays in vitro and in vivo were used to determine if the fluorinated cannabinoid derivatives behaved as partial agonists and/or PAMs. …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
… cell tropism, with porcine alveolar macrophages (PAMs) as important host cells. In 2006, most swine farms in China experienced a “high fever disease of swine” caused by new PRRSV variants, which led to great economic losses to Chinese swine industry, bring new challenge to the prevention and …
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Identificação e caracterização de um peptídeo antimicrobiano de Hypsiboas semilineatus
… antimicrobianos convencionais. A maioria dos PAMs atua ao nível da membrana plasmática do micro-organismo, interferindo na sua estrutura e permeabilidade, mecanismo o qual previne que o micro-organismo alvo desenvolva resistência ao peptídeo. A pele de anuros (sapos, pererecas e rãs) é uma …
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Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
… as 5-HT2CR positive allosteric modulators (PAMs). Several analogues potentiated intracellular calcium release by 5-HT in h5-HT2CR-CHO cells. Several compounds exhibited a favorable overall pharmacokinetic profile and modulated 5-HT2CRassociated behaviors (e.g., spontaneous motor activity and …
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A novel CRISPR-Cas9 platform with divergent targeting capabilities
… bioinformatics pipeline, the Search for PAMs by ALignment Of Targets (SPAMALOT), which further explores the microbial PAM diversity of otherwise-overlooked Streptococcus Cas9 orthologs. Our results establish that ScCas9 can be utilized both as an alternative genome editing tool and as a …
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A Mixed Method Approach to Post-Awakening Cortisol Research: Exploring Associations with Post-Awakening Melatonin, Primary Open-Angle Glaucoma and Experiences of Participation
… (PACS) and postawakening melatonin secretion (PAMS). Loss of mRGCs have been implicated in those with primary open-angle glaucoma (POAG). The second study therefore explored the relationship of PACS with primary open-angle glaucoma (POAG); a previously unstudied group. In the final study, an …
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A Machine Learning-Based Heuristic to Explain Game-Theoretic Models
… while also improving numerical tractability of PAMs. Consequently, enhancing policy design and operational decisions, and advancing real-time decision support where understanding and justifying decisions is crucial.
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Structured meshes: composition and remeshing guided by the Curve-Skeleton
… of PAM's. Since both quad layouts and PAMs exploit their global struc- ture, similarities between the two will be discussed, especially how their structure has correspondences to the curve-skeleton describing the topology of the shape being represented. Since both the presented methods …
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