Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"P2Y"”.
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THE ROLE OF P2Y RECEPTORS IN HUMAN VASCULAR SMOOTH MUSCLE
… were ineffective, ruling out the involvement of P2Yi, P2Yi2, P2Yi3 and P2Yii receptors respectively. This suggests that the proproliferative action of ATP is at P2Y2 receptors, whilst the anti-proliferative action is at P2Y4 (UTP) and P2Y6 (UDP) receptors. In SV cells, the marked downregulation …
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Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells
… mimic the third extracellular loop of the human P2Y2 receptor, the aim of this study was to use this peptide as an immunogen to generate and fully characterise polyclonal rabbit antibodies to the P2Y2 receptor. Other aims of this study were to characterise epithelial and endothelial cells for a …
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The role of the microglial P2Y₆ receptor in ageing, development, and tauopathy
… has shown that activation of the microglial P2Y₆ receptor (P2Y₆R) with uridine diphosphate (UDP) induces microglial phagocytosis. Also, young mice with knockout of the P2Y₆R gene (*P2ry6⁻´⁻*) were found to perform worse in memory tests compared to *P2ry6⁺´⁺* mice, but *P2ry6⁻´⁻* mice were …
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Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system
… receptors (P2X) and G protein-coupled receptors (P2Y) on post-synaptic cells. In addition to its role as a neurotransmitter, ATP and other nucleotides are known to be released from injured or ischemic tissue and have been reported to affect inflammatory events in the brain and many other tissues, …
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PURINERGIC TRANSMISSION IN MIGRAINE: ROLE OF P2Y RECEPTORS IN THE SPINAL-TRIGEMINAL SYSTEM IN VIVO AND IN VITRO
… receptors, while SGCs are highly responsive to P2Y-agonists (i.e., ADP, UTP, and UDP). Moreover, exposure to the pro-inflammatory agent BK significantly modified P2X3 receptor function in a biphasic way, with an upregulation or a reduction of alpha,beta-meATP-mediated calcium responses after an …
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Extracellular Nucleotides Induce Transient Elevation of Cytosolic Calcium in Articular Chondrocytes
… that can regulate cell behavior by binding to P2Y receptors. Our objective was to test the effect of nucleotides on P2Y receptor activity in live articular chondrocytes by monitoring changes in the concentration of cytosolic free calcium. ATP and UTP induced large transient elevations of …
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Einfluß von Nukleotiden und Nukleosiden auf humane dendritische Zellen
… mir im Rahmen dieser Arbeit der Nachweis der P2Y-Rezeptorsubtypen P2Y1, P2Y4, P2Y6 und P2Y11 sowie der Adenosinrezeptorsubtypen A1, A2a und A3 auf unreifen DCs. Nach LPS-induzierter Ausreifung der Zellen wurde die mRNA der P2Y-Subtypen sowie die der A2a-Rezeptoren von den DCs exprimiert. …
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Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation
… activate GABAergic interneurons by binding the P2Y receptor (Bowser & Khakh, 2004; Quon et al., 2018). Aside from the release of gliotransmitters astrocytes also have an important role in regulating extracellular potassium (K+) concentrations. Modulation of extracellular K+ can lead to changes …
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Mitogene Effekte extrazellulärer Nukleotide in humanen Mesangialzellen
… Charakterisierung scheinen verschiedene P2Y-Rezeptoren an den Wachstumsvorgängen beteiligt zu sein: P2Y1-, P2Y2-, P2Y4- und P2Y11-Rezeptor. Die Bindung an Purinrezeptoren aktiviert im weiteren Verlauf die MAP42/44 Kinase Kaskade. Es konnte kein Hinweis gefunden werden, dass ATP auch über …
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Synthesis and biological evaluation of purine and pyrimidine based ligands for the A3 and P2Y2 purinergic receptors
P1-receptors, or adenosine receptors, and P2Y receptors, are G-protein-coupled receptors, belonging to the purinergic receptor family. Adenosine is the natural ligand of the P1 receptors, while P2Y receptors are activated by nucleotide ligands (ATP,ADP, UTP and UDP). The adenosine receptors (P1) …
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The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection
… adrenergic receptors and Gq-coupled UTP-binding P2Y purinergic receptors on H9c2 cells. Activation of the adenosine A1 receptor with CPA (N(6)-cyclopentyladenosine) provided significant protection against hypoxia-induced cell death in these cells, as did opening of a BKCa channel with NS1619. The …
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Il nucleotide extracellulare UTP: induzione della migrazione di cellule staminali emopoietiche CD34+
… segnale attivate dalla stimolazione di recettori P2Y con UTP. Esperimenti di inibizione in presenza della tossina della Pertosse hanno evidenziato il coinvolgimento di proteine Gαi nella migrazione dipendente da CXCL12 ed UTP. Ulteriori indicazioni sono provenute dall’analisi del profilo …
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Pharmakologische Charakterisierung der purinergen Rezeptoren der Stützellen der olfaktorischen Mukosa des larvalen Xenopus laevis
… durch die Aktivierung von G-Protein gekoppelten P2Y-Rezeptoren ausgelöst werden. Die ermittelte Wirkpotenz purinerger Agonisten war UTP>ATP>ATPγS. Die ATP-induzierten [Ca2+]i-Zunahmen konnten durch die purinergen Antagonisten PPADS und RB2 reduziert werden. Die hemmende Wirkung des purinergen …
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Development of a Microplate-Based Calcium Assay for Studying Desensitization of the P2Y2 Nucleotide Receptor
… either the ionotropic P2X family or metabotropic P2Y family of nucleotide receptors. The P2Y2 receptor (P2Y2R) regulates several important processes, such as inflammation, neuroprotection, and NaCl balance on the airway surface and in the kidneys. Prolonged stimulation of the P2Y2R leads to …
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The role of the P2Y2 nucleotide receptor in salivary gland regeneration
… therapies for damaged salivary glands. The P2Y2 nucleotide receptor (P2Y2R), a G protein-coupled receptor equipotently activated by ATP and UTP, is upregulated in a variety of tissues, including salivary gland epithelium, in response to injury or stress and is proposed to play important …
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Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
… rod formation by binding to P2X and P2Y cell surface receptors. In our peptide inhibition strategy, we discovered three peptides that inhibit actin-cofilin rod formation in cells undergoing energetic stress. These peptides were found to significantly decrease the length of native …
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
… release of extracellular nucleotides acting on P2Y receptors, leading to increased [Ca2+]i and subsequent activation of calcineurin and NFATc3. It also decreases the export of NFATc3 from the nucleus by inhibition of GSK-3beta and JNK activity. Arteries of diabetic patients display increased …
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ADP regulation of insulin secretion and beta-cell apoptosis
… via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… on the other hand antagonizes ADP receptor P2Y12. ADP is a weak platelet agonist stored in platelet dense granules and is released upon platelet activation. ADP activates platelets through two purinergic receptors namely P2Y1 and P2Y12 these receptors couple to Gq and Gi class of G-proteins, …
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Dining in the Dark ATP Sensing in the Female Aedes Aegypti Mosquito
… any orthologs of vertebrate extracellular P2X or P2Y ATP receptors, we focused on ionotropic receptors (IRs), a large family of chemosensory receptors in insects that has previously been shown to respond to stimuli ranging from olfactory to taste to thermal cues. IRs form heteromeric ligand-gated …
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