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Showing 1 to 20 of 106 for “"Oxidases"”.
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Production of novel amine oxidases from microorganisms
… industrial production were established. Amine oxidases exhibit stereoselectivity, and, therefore, can potentially be used for the deracemisation of non-optically pure mixtures of amines leading to optically pure amines of high value in the fine chemical and pharmaceutical areas. Initially, …
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Biocatalytic studies of phenol oxidases producing antioxidants
In recent years there has been increasing interest in the production of oligomers and polymers of economic importance using biocatalysts; the application of enzymes in dimerisation or polymerisation processes can lead to the synthesis of unique compounds, with novel properties, that could not be …
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Function of multicopper oxidases adsorbed on gold nanoparticles /
… bioelectrocatalytic functions of multicopper oxidases adsorbed on gold nanoparticles are studied. As multicopper oxidases, laccases and human ceruloplasmin are used. The enzymes have been employed in electrochemical systems consisting of gold electrodes covered by gold nanoparticles and …
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Structure-Function Relationship Studies of the Cytochrome Oxidases
Finally, there is evidence of radical migration in the bovine cytochrome c oxidase. Upon formation of the P-state a band was seen by SDS-PAGE analysis that migrated faster than the carbonic anhydrase standard (molecular weight 36800). MALDI-TOF mass spectrometry analysis identified this as a single …
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Examining the Proton Channels in Heme -Copper Oxidases
Previous work on the mutant enzyme KI-362M indicated that a block in the K-channel would result in the blockage of the catalytic cycle between the oxidized state and the two electron reduced state. This blockage occurs because an electron cannot enter the binuclear center without a proton to …
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Methodological and biological studies of the amino acid oxidases.
… amino acid substrates by the D- and L-amino acid oxidases is coupled to the NALH dependent reductive amination of 2-oxoglutarate, the reaction being catalysed by exogenous glutamate dehydrogenase L-glutamate: NAL(P) oxidoreductase (deaminating), EC 1.4.1.3.). The inhibition of L-amino acid oxidase …
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Rational design of functional heme copper oxidases in myoglobin
… complex metalloproteins, such as heme copper oxidases (HCOs) in respiration or the oxygen evolving complex in photosystems. Large complex proteins pose two problems with respect to studying function. Large complexes are relatively difficult to isolate in a biologically relevant form and the …
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Characterization of NADPH Oxidases in Uterine Smooth Muscle during Pregnancy
… Nicotinamide adenine dinucleotide phosphate oxidases (Nox) are proteins responsible for the transport of electrons across biological membranes. It was hypothesized that Nox proteins and their regulatory subunits would be readily expressed in the rat myometrium during pregnancy to help prepare …
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Spectroscopic analysis and dynamics of ligand binding to bacterial oxidases
… chain of Escherichia coli contains two terminal oxidases, the cytochrome bd complex and the cytochrome bo complex. Each of these enzymes functions as a ubiquinol oxidase and reduces molecular oxygen to water. Although the two enzymes perform the same function they do not show any obvious …
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Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species
This work involved the characterisation of protoporphyrinogen oxidase (PPO), the penultimate enzyme in haem biosynthesis, from Bacillus subtilis, Myxococcus xanthus, and human. A defect in human PPO causes variegate porphyria, an autosomal dominant disorder characterised by skin photosensitivity …
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Studies of Cytochrome C Oxidases From Rhodobacter Sphaeroides and Vibrio Cholerae
… the current studies show that cytochrome cbb3 oxidases apply quite distinct mechanism for receiving electrons and pumping protons. The work in this thesis clearly demonstrates that B- and C-type oxidases have less energy coupling efficiency and share a similar pumping mechanism other than …
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Studies of cytochrome c oxidases from Rhodobacter sphaeroides and Vibrio cholerae
… the current studies show that cytochrome cbb3 oxidases apply quite distinct mechanism for receiving electrons and pumping protons. The work in this thesis clearly demonstrates that B- and C-type oxidases have less energy coupling efficiency and share a similar pumping mechanism other than …
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Role of Mixed Function Oxidases of Insects in Their Response to Xenobiotics
Made available in DSpace on 2014-12-11T18:05:37Z (GMT). No. of bitstreams: 1 7206872.pdf: 9302977 bytes, checksum: eae36cd9999a9d95d6e83c35fa4a0610 (MD5) Previous issue date: 1971
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Engineering heme-copper and multi-copper oxidases for efficient oxygen reduction catalysis
… frequency and low overpotential Heme-copper oxidases catalyze four-electron reduction of oxygen to water, and the energy harvested is utilized to drive the synthesis of adenosine triphosphate. While much effort has been made to design a catalyst mimicking the function of terminal oxidases, …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… stress and increased vascular tone. NADPH oxidases are enzymes whose primary function is to produce ROS, with NOX2 and NOX4 both highly expressed in ECs and upregulated in diabetic and failing hearts. Our hypothesis was that endothelial-specific NOX2 and NOX4 play a key role in regulating …
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Using myoglobin models of oxidases for mechanistic understanding of the oxygen reduction reaction
… reaction to take place in metalloenzymes like oxidases, but strangely, there is a high degree of variance in the active site of these enzymes. Studying the native enzymes has proven difficult using traditional methods due to the insoluble nature of oxidases along with many complicating features …
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Flavin Amine Oxidases from the Monoamine Oxidase Structural Family Utilize a Hydride Transfer Mechanism
… kinetic analyses of two flavin amine oxidases, mouse polyamine oxidase (PAO) and human lysine specific demethylase (LSD1), to determine the mechanisms of amine oxidation. PAO is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the oxidation of N1-acetylated …
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An Investigation of Cytochrome Bd Quinol Oxidases of Vibrio Cholerae, Rhodobacter Sphaeroides, and Salmonella Typhimurium
Chapter four describes the discovery of novel members of the tri-heme family in R. sphaeroides and V. cholerae. Combining spectroscopy and activity studies with recombinant gene expression and mutagenesis, it was shown that these two organisms might harbor an oxidase that is distinct from the bd-I …
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Discovery and characterization of a set of peptide-modifying heme oxygenase-like domain-containing oxidases
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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