Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Neuron Types"”.
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Deterministic Barcoding of Neuron Identities through Multicolor Fluorescent Markers in C. elegans
Mapping the connectivity of neurons, or the brain connectome, with a clear identification of neuron types and functions is a complicated problem that hinders the development of potential therapeutic interventions. Without understanding the identities of neurons that have fundamental roles in …
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Mass spectrometry-based investigations to characterize specific cell types within the brain
… of the brain and its many constitutive cell types yield information regarding normal and abnormal brain function. Frequently, proteomics, peptidomics, and metabolomics experiments survey brain regions and attribute detected species to neurons. However, many other cell types are present, …
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Striatal Control of Sensory-Driven Behavior and Its Relevance for Neuropsychiatric Disorders
… while we recorded cell-specific activity from TS neurons to identify how distinct striatal pathways contribute to sound-driven behavior. Both major striatal neuron types were active during reward-related target sounds, whereas non-target stimuli preferentially engaged neurons of the indirect …
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Cellular and Molecular Mechanisms of Retinal Neuron Spatial Patterning
… system, cell recognition cues guide migrating neurons during development to appropriate terminal locations and sculpt their characteristic sizes, shapes, and circuit connectivity. The retina contains a multitude of neuron types; however, neurons of the same cell type (homotypic) are patterned …
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Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
… 2 A. Basal forebrain of mammals 2 B. Neuron types in the basal forebrain 2 C. Alzheimer’s disease 3 D. Normal functions of tau protein 4 E. Structure and Posttranslational Modifications of the Tau Protein 5 F. Distribution of tau phosphorylation sites and NFT formation in AD …
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Computational Approaches to Predict Effect of Epigenetic Modifications on Transcriptional Regulation of Gene Expression
… brain cell differentiation into different neuron types, regulation of memory and promotion of normal brain development at the early stages of life.
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Functional relationship between forebrain cholinergic projections and somatostatin neurons in the rat
The two neuron types that initially degenerate with Alzheimer's Disease are the cholinergic projections from the septum to the hippocampus and from the substantia innominata to the cortex, and the somatostatinergic neurons in the hippocampus and cortex. The functional relationship between these two …
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Computational Modelling of Functionally-Identified Retinal Ganglion Cells using a Multi-Objective Optimisation Approach
… vision by selectively activating different neuron populations in a planned sequence and spatial pattern. However, current retinal neuroprostheses have limited ability in targeting different retinal neuron types. Improvements in the field of prosthetic vision are highly dependent on better …
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Stress-induced remodeling of the caenorhabditis elegans dauer
… changes to the dendritic architecture of neurons has been demonstrated in numerous mammalian and invertebrate systems; however, stress-induced remodeling of dendrites varies among neuron types. During the stress-induced dauer stage of Caenorhabditis elegans, the IL2 neurons arborize to …
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Mash1 Defines Lineage Restricted Neuronal and Oligodendrocytic Precursor Cells in Spinal Cord Development
… distinct neural progenitor and early interneuron pools in the developing spinal cord and the molecular events that influence progenitor cell fate. However, these early neurons have not been traced to adult neuron types. The transcription factor Mash1 is transiently expressed in a subset of …
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Validating ngn-1 transcriptome targets in C. elegans
… required for fate specification of multiple neuron types and brain structures. Despite its importance in nervous system development and function, the immediate downstream targets of neurogenin are not well characterized. The nematode <em>Caenorhabditis elegans</em> contains a single …
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Determining how stable network oscillations arise from neuronal and synaptic mechanisms
… an oscillatory activity pattern, where different neurons maintain a relative phase relationship. This thesis examines the relationships between the cellular and synaptic properties that give rise to stable activity in the form of phase maintenance, across different frequencies in a well-suited …
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The effects of periodic and non-periodic inputs on the dynamics of a medial entorhinal cortex layer II stellate cell model
Various neuron types exhibit sub-threshold and firing frequency resonance in which the sub-threshold membrane potential or firing frequency responses to periodic inputs peak at a preferred frequency (or frequencies). Previous experimental work has shown that medial entorhinal cortex layer II …
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Interaction between Adrenergic and Nitric Oxide-releasing Nerves in Cerebral Arteries
… examined the interaction between these two nerve-types with emphasis on the mechanisms involved as well as on changes in their functions as the animal adapts to stress such as chronic hypoxia.</p> <p>An overview of endogenous NO which is synthesized by nNOS, reveals that NO exhibits numerous and …
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Distinct Populations of Layer 5B Pyramidal Neurons in the Primary Motor Cortex
… depends on the coordinated activity of many neurons found across its laminar structure. Layer 5b (L5b), a deep cortical layer that drives output signals from the cortex, contains excitatory pyramidal neurons that innervate many subcortical areas of the brain. In the motor cortex, L5b is …
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Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks
In response to oscillatory input, many isolated neurons exhibit a preferred frequency response in their voltage amplitude and phase shift. Membrane potential resonance (MPR), a maximum amplitude in a neuron’s input impedance at a non-zero frequency, captures the essential subthreshold properties of …
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Signal transformation at the input and output of the Drosophila visual system
… I studied the filtering property of visual neurons at two levels, biophysical and circuit levels. The first study looks at signal transformation at the biophysical level, at the input of the visual system, in photoreceptors. Voltage-gated potassium channels counteract the depolarization …
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High-Throughput Operant Conditioning in Drosophila Larvae
… of reward-encoding dopaminergic and serotonergic neurons is sufficient to induce a learned preference for bending towards this side after training. I explore whether there are other types of actions which larvae can learn to associate with valence, and introduce a second operant conditioning …
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