Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 213 for “"Neuroblastoma"”.
-
Novel Neuroblastoma Differentiating Agents
Neuroblastoma (NB) is the 3rd most lethal pediatric cancer. In high-risk patients, the 5-year survival rate is 40-50% after treatment. The differentiation therapy with retinoic acid (RA) is at the forefront of approaches to treat neuroblastoma; however, more than half of patients experience …
-
Notch Signaling in Human Neuroblastoma Cells
Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, …
-
Oncogenic Pathways and Molecular Prognostics in Neuroblastoma
Neuroblastoma is an embryonal malignancy that accounts for 15% of all cancer related deaths amongst children. Although the overall survival of patients has been improving over the last decades, the high-risk neuroblastoma patients have a survival rate of <50%. Using gene expression microarrays we …
-
Integrative analysis of the metastatic neuroblastoma transcriptome
Neuroblastoma (NBL), the most common non-Central Nervous System (CNS) solid tumor of childhood, characteristically displays heterogeneous clinical presentation and biological behavior. Previous work has studied the genetic basis of the disease and revealed a low somatic mutation burden. In order to …
-
The Protumorigenic Role of Caspase-8 in Neuroblastoma
<p>Neuroblastoma (NB), the most common extracranial solid tumor in children, accounts for 15% of cancer-related deaths in pediatric patients. Caspase-8 (casp8), a proapoptotic protein, is silenced in approximately, 50-70% of neuroblastoma patient samples. Loss of casp8 has been suggested to …
-
Hypoxia-induced phenotypic modulation of human neuroblastoma cells
Neuroblastoma is a childhood tumour derived from cells of the sympathetic nervous system, which are arrested at low differentiation stages. Low differentiation stage and high tumour stage correlate to poor outcome. In earlier studies we have found that hypoxia induces dedifferentiation of …
-
Hypoxic gene regulation and oncogenic pathways in neuroblastoma
Neuroblastoma patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates …
-
Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
… apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor derived from cells of the sympathetic nervous system, arrested at an immature stage of differentiation. Notch signaling is thought to play an important role during the development of the sympathetic nervous …
-
Role of ASCL1 and Its Interactors in Neuroblastoma
Neuroblastoma (NB) arises due to incomplete differentiation of sympathoadrenal cells during development, and is maintained by either an adrenergic or mesenchymal core transcriptional regulatory circuitry (CRC). Differentiation therapies are an attractive therapeutic approach for NB. However, it is …
-
FUNCTIONAL ROLE OF NON-CODING REGULATORY VARIANTS IN NEUROBLASTOMA
… whole-genome sequencing (WGS) data from 151 neuroblastoma primary tumours identified two clusters of non-coding Single Nucleotide Variants (SNVs) in two distinct cis-Regulatory Elements specifically active in neuroblastoma (aCREs), denominated CTTNBP2-aCRE and MCF2L-aCRE based on their …
-
The role of the YTHDF m6A readers in neuroblastoma
Neuroblastoma (NB) is the most common extracranial solid tumor diagnosed in the first year of life. The disease is characterized by lack of somatic mutations and high genomic instability including the amplification of MYCN which correlates with poor clinical outcome. These features of NB suggest a …
-
Combination Therapy For the Treatment of Human Malignant Neuroblastoma
<p>Neuroblastoma is a tumor of sympathetic nervous system origin and the most common extracranial heterogenous solid tumor of childhood affecting primarily infants. Despite multimodal conventional therapeutic approaches including chemotherapy, radiation therapy, immunotherapy, and neurosurgery, the …
-
Neuroblastoma: A Theoretical Dose Dependent Study With Therapeutic Implications
<p>Neuroblastoma is the most prevalent extracranial childhood solid tumor with several stages of disease. While many children have an aggressive metastatic form of the disease, spontaneous regression has also been well documented. Individualized treatments are required due to the spectrum of …
-
The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
<p>Neuroblastoma is a pediatric cancer arising from undifferentiated neural crest-derived precursor cells. Treatment strategies for neuroblastoma aim to promote neuroblast differentiation, however current therapies available are only modestly effective. The tumor stroma contributes to the …
-
RGS2 Modulation of Dopamine D2 Receptor Trafficking in Neuroblastoma Cells
Dysregulated D2R expression and function is implicated in the pathophysiology of many diseases including Parkinson’s disease, schizophrenia, and drug addiction. D2R trafficking is vital to proper D2R function. While the expression and activity of D2Rs are altered in the pathology of these diseases, …
-
Electrochemical Determination of Extracellular Phosphorylation in Neuronal and Neuroblastoma Cells
… phosphorylation profiles of human neuron and neuroblastoma cells through the use of surface-based electrochemical sensors. This investigation started by demonstrating electrochemistry as a simple and effective technique to determine the phosphorylation state of neuronal proteins. The nAChR α7 …
-
Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy
<p><strong>Introduction</strong>: Neuroblastoma is the most common cancer of infancy. It is one of several peripheral nervous system tumors, including ganglioneuroma, peripheral nerve sheath tumor, and pheochromocytoma. It is commonly situated on the adrenal gland. It displays similar histology to …
-
Inhibition of KDM4 with QC6352 to Target High-Risk Neuroblastoma
<p>Neuroblastoma (NB) is a malignancy of improperly maturated nerve tissues of the sympathetic nervous system. It is the most diagnosed extracranial solid tumor of childhood, and it accounts for roughly up to 10% of all childhood malignancies and 15% of all childhood malignancy-related deaths. MYCN …
-
Characterizing ALCAM as an oncoprotein and immunotherapeutic target in neuroblastoma
Neuroblastoma is the most common extracranial solid malignancy in children. Half of children diagnosed with neuroblastoma are considered high-risk for relapse based on clinical and tumor biological features of their tumors, and only half of high-risk patients will survive five years. Although …
Page 1 of 11