Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"NMDAR"”.
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… of N-methyl-D-aspartic acid receptors (NMDARs). Stimulation of NMDARs recruits neuronal nitric oxide synthase (nNOS) to the synaptic scaffolding protein, postsynaptic density protein 95 (PSD95), to produce nitric oxide (NO). Our laboratory has previously shown that disruption of the …
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Regulation of Molecular Composition at Glutamatergic Synapses
… (N-Methyl-D-Aspartate Glutamate Receptor, NMDAR) molecular markers in rat hippocampal cultured neurons. PROT localized specifically to presynaptic excitatory synapses. Immunostaining of PROT was detected several days following synapse formation, suggesting a regulatory function for the …
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… Ca2+-permeable N-methyl-D-aspartate receptors (NMDARs). Their involvement in megakaryocytic maturation has been shown in 2003 but details remain limited. The importance of Ca2+ homeostasis in malignant megakaryocytes has been further highlighted only in 2013 through the discovery of Calreticulin …
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… glutamatergic N-methyl-D-aspartate receptors (NMDAR) have been shown to be involved in other neuroprotective preconditioning mechanisms. <bold>I hypothesize that MEP mediates neuroprotection from Aβ by the sensor activity of one or more of these cell surface receptors</bold>. The experiments …
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Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
… revealed novel N-methyl-D-aspartate receptor (NMDAR) nucleus-specific and frequency-dependent functional diversity in the somatosensory CT circuit. Specifically, these findings illustrate the different effects of NMDAR negative modulation in the nRT and the VPM, which offers a method to …
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Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
… loss. Synaptic N-methyl-D-aspartate receptor (NMDAR)- activity can drive the expression of PGC-1α which is neuroprotective against oxidative and excitotoxic stress in vitro whereas extrasynaptic NMDAR expression is increased in HD. Excessive NMDAR activity, specifically through extrasynaptic …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
The NMDA receptor (NMDAR) hypofunction hypothesis in schizophrenia posits that reduced NMDAR function leads to behavioral abnormalities observed in schizophrenia. Lower expression of GluN2C subunit of NMDAR has been reported in the cortex and thalamus in postmortem brains from schizophrenic …
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Effects of perinatal phencyclidine treatment on neuronal viability, N-methyl-D-aspartate receptor regulation and schizophrenic-like behaviors
… major actions as a noncompetitive NMDA receptor (NMDAR) antagonist. Administration to immature rats has been shown to cause neurotoxicity in a regional and treatment dependent manner and development of schizophrenic-like behaviors later in life. The purpose of this study is to determine the …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… in glutamate spillover and activation of NMDARs. Further investigation showed that L-TBA-mediated activation of NMDARs was facilitated by the Mg2+ unblock of the receptor. Furthermore our data indicate that NMDAR signaling was controlled by the interplay between several factors, including …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… in glutamate spillover and activation of NMDARs. Further investigation showed that L-TBA-mediated activation of NMDARs was facilitated by the Mg2+ unblock of the receptor. Furthermore our data indicate that NMDAR signaling was controlled by the interplay between several factors, including …
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Probing spatial and subunit-dependent signalling by the NMDA receptor
NMDARs are ligand-gated cation channels which are activated by the neurotransmitter glutamate. NMDARs are essential in coupling electrical activity to biochemical signalling as a consequence of their high Ca2+ permeability. This Ca2+ influx acts as a secondary messenger to mediate neurodevelopment, …
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Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… the developmentally regulated GluN3A subunit in NMDAR-induced transcription. I observed that neurons lacking the transcription factor CaRF showed enhanced NMDAR-induced expression of Bdnf and Arc both in cultured neurons and following sensory stimulation in the developing brain in vivo. I …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in this study, we used a sodium channel activator, brevetoxin-2 (PbTx-2) to mimic neuronal activity. …
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
… activity in SNc-DA neurons. NMDA receptors (NMDARs) bind the excitatory neurotransmitter glutamate, and are essential for learning and memory. In SNc-DA neurons, NMDARs have a putative triheteromeric subunit arrangement of GluN1 plus GluN2B and/or GluN2D. Wild type (WT) mice, and those …
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Social isolation enhances calcium signaling and synaptic plasticity in dopamine neurons of the ventral tegmental area
… (LTP) of N-methyl D-aspartate receptor (NMDAR)-mediated glutamatergic transmission in the VTA. Activation of NMDARs is critical to the generation of DA neuron bursts that encode rewards and reward-predictive cues, and NMDARs are necessary for associative reward learning. The …
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IDENTIFYING THE GENETIC MECHANISMS IN SEIZURE THRESHOLD REGULATION
… of N-Methyl-D-Aspartate type glutamate receptor (NMDAR) activity in cortical neurons. The 3’ untranslated region (3’UTR) of PTGS2 gene was found to be a key site of post-transcriptional regulation by NMDAR activity. However, deletion of T-cell intracellular antigen-1 (TIA-1), an RNA binding …
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RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
… of the NMDA-type glutamate receptors (NMDARs) at the cell surface, forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation (LTP) induction and NMDAR-dependent hippocampal behaviors, such as spatial learning. Under …
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Synaptic Mechanisms Underlying Treatment of Depression and Bipolar Disorder
Ketamine is a N-methyl-D-aspartate receptor (NMDAR) antagonist that elicits rapid antidepressant responses in depressed patients. However, ketamine can also produce psychotomimetic effects, which limits its widespread use. The field has been exploring the mechanism of ketamine's antidepressant …
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Synapse Dysfunction Induced by Autism Spectrum Disorder Associated Shank3 Mutations
… aim, we induced N-Methyl-D-aspartate receptor (NMDAR)-dependent long term potentiation (LTP), NMDAR-dependent long term depression (LTD), or metabotropic glutamate receptor (mGluR)-dependent LTD in neurons overexpressing Shank3, shRNA-Shank3 or ASD-associated mutant forms of Shank3. Neurons …
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The Master Synaptic Regulator: Activity Regulated Cytoskeleton Associated Protein, Arc, in Normal Aging and Diseases with Cognitive Impairment
… Arc expression is increased in response to NMDAR and insulin receptor stimulation and these stimulation-elicited Arc increases are dramatically attenuated in AD. We present evidence to show Arc is regulated by phosphorylation on the serine and tyrosine residues and this post-translational …
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