Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"MyoD"”.
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Transcriptional Regulation of the Xenopus MyoD Gene
MyoD is one of the MRFs (Muscle Regulatory Factors) and it functions to determine the muscle cell fate. The mechanism by which MyoD regulates the muscle development program is very well understood. However, the transcriptional regulation of the MyoD gene itself has not studied in Xenopus. In this …
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Characterizing the Mechanisms Regulating Enhancer Commissioning by MyoD in Muscle Cells
… by master transcription factors such as MyoD. While MyoD is crucial for muscle development and differentiation due to its role in initiating muscle-specific gene expression, the mechanisms used to regulate MyoD function at different stages of myogenesis remain poorly understood. To better …
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Structural studies on the basic-helix-loop-helix region from MyoD
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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Direct Reprogramming Of Fibroblasts Into Muscle Or Neural Lineages By Using Single Transcription Factor With Or Without Myod Transactivation Domain
… factors (Pax3 or NeuroD1) with the potent MyoD transactivation domain (MDA) that could facilitate radical acceleration of reprogramming into the desired cell type through chromatin modification compared to wild-type factors. Here, we showed that Pax3 can reprogram MEFs towards a myogenic …
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Funktionelle Charakterisierung unkonventioneller Myosine aus Dictyostelium discoideum
… Dictyostelium discoideum charakterisiert. MyoD und MyoE liegen angereichert in dynamischen Regionen des Zellcortex und an aktinreichen Membranstrukturen vor. Während der Mitose ist MyoD an Teilen des Spindelapparats und an der Kernhülle lokalisiert, die während der Zellteilung erhalten …
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Functional Genomics Characterization of Six4 During Skeletal Myogenesis
… muscle regeneration. The ability of the MRF MyoD, a central regulator of skeletal myogenesis, to convert a non-muscle cell model into the myogenic lineage was impaired with attenuated Six4 expression. I employed genome-wide approaches by combining ChIP-sequencing with gene expression …
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Funtional Analysis of the Murine Genes, MOCS1 and Sox15
… Hinweise auf eine Herunterregulierung der MyoD-Expression (myogenetic regulatory factor), während Myf5 hochreguliert wird. Hinweise auf die Fähigkeit von Sox15 Proteinen zur Bindung einer auf der distalen Regulationsregion von MyoD lokalisierten DNA binding site ergeben sich durch …
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ΕΠΙΔΡΑΣΗ ΤΗΣ ΜΗΧΑΝΙΚΗΣ ΦΟΡΤΙΣΗΣ ΣΕ ΦΥΣΙΟΛΟΓΙΚΟΥΣ ΚΑΙ ΓΗΡΑΣΜΕΝΟΥΣ ΣΚΕΛΕΤΙΚΟΥΣ ΜΥΟΒΛΑΣΤΕΣ
… μυοσωληνίσκους C2C12. Μελετήθηκαν τα γονίδια MyoD, Myf5 και Myogenin ως δείκτες μυογένεσης, το Myostatin ως αρνητικός ρυθμιστής μυϊκής ανάπτυξης και ο παράγοντας Klotho, που έχει συνδεθεί με αντιγηραντικές ιδιότητες. Τα κύτταρα καλλιεργήθηκαν σε Passage 14 (φυσιολογικός φαινότυπος) και Passage …
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Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
… myogenic basic-helix-loop-helix proteins such as MyoD or myogenin bind. Moreover, myogenic differentiation is completely blocked, when ERK5 expression is inhibited by antisense RNA. The effect can be detected also on the expression level of myogenic determination and differentiation markers such …
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Role of JAK3 in Myogenic Differentiation
… of myosin heavy chain (MHC), myogenin (MGN), MyoD, and myogenic enhancer factor 2 (MEF2). Knockdown of the JAK3 gene using siJAK3 also significantly increased MHC, MGN and MyoD mRNA expressions as well as insulin-like growth factor-II (IGF-II) gene expression. During differentiation, JAK3 was …
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Tissue Engineering von Skelettmuskulatur : Vergleich eines in vitro und in vivo Ansatzes
… dienten die Transkriptionsfaktoren der Myogenese MyoD und Myogenin als auch die Expression der Epsilon-Untereinheit des adulten Azetylcholinrezeptors. <br>Zunächst wurde die Genexpression der Muskelvorläuferzellen in 2D-Zellkultur und 3D-Fibrinkultur untersucht und verglichen, dabei konnte …
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Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
… from the shared genome. ASCL1, ASCL2, and MYOD are class II basic Helix-Loop-Helix (bHLH) transcription factors which play crucial roles in lineage specification in the developing embryo. In vivo, these factors bind to distinct genomic sites, and regulate distinct transcriptional programs. …
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Growth Differentiation Factor 5 is a Paracrine Regulator of Sarcopenic Obesity
… Markers for myogenic regulation (Cyclin D1, MyoD, MyoG), protein degradation (Atrogin, MuRF1) and inflammatory markers (IL-6, TNF-α) were assessed using RT-PCR for mRNA abundance. Results: There was a 62% and 30% (p<0.05) decrease of Gdf5 protein expression at 28 kDa and 55 kDa in the shRNA 1 …
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Development of a novel co-culture based in vitro model system to study the wound healing process
… that the peridural scar tissue contained MyoD-positive myoblast cells and expressed prolyl-4-hydroxylase (P4H), a fibroblast marker. Treatment with 1 mM OTC reduced activation of ERK1/2 and p38 mitogen-activated protein kinases (MAPK) at 21 days post-surgery suggesting potential …
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Regulation of human satellite cells in vitro via inflammatory cytokines and myogenic transcription factors across proliferation and differentiation
… Additionally, mRNA levels of Pax7, MyoD, myogenin, IL-6, TNF-α, and TGF-β were assessed in satellite cells cultured from a subset of two endurance trained and two sedentary individuals from the larger group of 12 human subjects. The novelty of our study is the large number of human …
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Genomic characterization of Six1 function during skeletal muscle differentiation
… in skeletal muscle development, and comprise MyoD, Myf5, Myogenin and Myf6. Based on previous bioinformatics predictions, it was proposed that Six1 had a genome-wide function and cooperated with MRFs by co-regulating gene expression. A functional genomics approach (ChIP-on-Chip) was used to …
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TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA
… showed that TBX2 forms complex with myogenin and MyoD, and then recruits HDAC1 to muscle-specific promoters to repress the myogenin and MyoD dependent differentiation of myoblasts. In rhabdomyosarcoma (RMS), which is typically referred to as a muscle derived cancer, we found TBX2 was over …
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Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV)
… increased interlukin-6 (IL6) and decreased MyoD. In addition, a novel transcriptional target of Mstn, the β1 subunit of the Na⁺-K⁺-ATPase was discovered. Treatment of ovine myoblasts with recombinant MSV induced a plethora of transcriptional responses. IPA analysis suggested a number of …
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Growth response to resistance exercise : influence of exercise device
… expression of Myogenin (3.6 vs. 3.6 fold), and MyoD (2.2 vs. 2.0 fold) and decreased (P < 0.05) expression of Myostatin (1.4 vs. 1.5 fold) to a similar degree on both exercise devices. There was no change in the expression of Atrogin-1, MuRF-1 or MRF4 following RE on either device. The only …
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Optimizing Ex Vivo Culture of Satellite Cells
… in inhibition of myogenic commitment factors, MyoD and Myogenin. SR1 also succeeded to block myoblast differentiation into myotubes. SR1 treated established myoblast cells succeeded to repopulate satellite cell pool of recipient muscles. SR1 is described to work through an action on AHR (aryl …
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