Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"Multi-target"”.
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Efficient Multi-Target Tracking using graphical models
… of this thesis is to develop a new framework for Multi-Target Tracking (MTT) algorithms that are distinguished by the use of statistical machine learning techniques. MTT is a crucial problem for many important practical applications such as military surveillance. Despite being a well-studied …
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Multi-target tracking via mixed integer optimization
Given a set of target detections over several time periods, this paper addresses the multi-target tracking problem (MTT) of optimally assigning detections to targets and estimating the trajectory of the targets over time. MTT has been studied in the literature via predominantly probabilistic …
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NATURE-INSPIRED COMPOUNDS AS MULTI-TARGET DIRECTED LIGANDS
… il design razionale di farmaci e agrofarmaci multi-target rappresenta uno strumento strategico. Si assume infatti che combinazioni sinergiche di scaffold bioattivi capaci di inibire simultaneamente più bersagli forniscano una migliore bio-attività, riducendo al contempo il rischio di …
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Thiazolidinone-isatin hybrids as multi-target anticancer agents
… of death in the world and, considering its multi-factorial origin it could be considered more a syndrome than a disease. Accordingly, in most cases the treatment consists of a combination of drugs that, due to their lack of selectivity and toxicity are often used at sub-optimal …
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Radar-Based Multi-Target Classification Using Deep Learning
Real-time, radar-based human activity and target recognition has several applications in various fields. Examples include hand gesture recognition, border and home surveillance, pedestrian recognition for automotive safety and fall detection for assisted living. This dissertation sought to improve …
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Mechanistic investigations on polyprenyl transferases and multi-target antibiotic discovery
… head-to-tail prenyl transferases are druggable targets in antibiotic development. In Chapter 2, I discuss the new series of lipophilic bisphosphonates that inhibit the growth of various bacteria and target multiple prenyl transferases. To determine and verify the enzyme targets of antibiotic …
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ALGORITHM DESIGN AND ANALYSIS IN DISTRIBUTED MULTI-ROBOT MULTI-TARGET TRACKING
… addresses the significant challenge of Multi-Robot Multi-Target Tracking (MR-MTT), a critical system in various scenarios, including search-and-rescue missions, surveillance, and environmental monitoring. MR-MTT involves coordinating a team of robots to track multiple dynamic targets in …
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Dynamic multi-target user interface design for grid based M-Services
… (PLD) method for automatic generation of multi-target user interfaces. The PLD method consists of user preference aware models, which are created at design time. Interface artifacts are considered in the PLD as methods with polymorphic attributes in a bid to address the diversities …
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Virtual Screening of Multi-Target Agents by Combinatorial Machine Learning Methods
Multi-target drugs have greatly attracted the attention and interest in drug discovery. As a joint effort, the Kinetics database of biomolecular interactions and the Therapeutic targets database were upgraded. They can offer informative data in multi-target drug discovery. I explored combinatorial …
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Multi-target Tracking Using on-line Viterbi Optimisation and Stochastic Modelling
… structure in the block. The second method is a multi-target tracker that uses the probabilistic background foreground segmentation to produce the trajectories of all objects in the scene. It operates online but with a few seconds delay in order to incorporate information from both past and …
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Multi-target drug discovery against Staphylococcus aureus and Trypanosoma brucei infections
… of resistance-resistant antibiotics that involve multi-targeting. To extend the potential utility of this class of amidine compound, we tested them against Trypanosoma brucei, the causative agent of human African trypanosomiasis. The most active compound was a biphenyldiamidine which had an EC50 …
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Mechanisms of bacterial polyprenyl transferases and multi-target drug discovery for tuberculosis
… dynamics measurements etc. Besides that, a multi-target drug discovery approach was also proposed as an attempt to combat drug resistance in anti-infective drug discovery campaigns, both based on structural homology of Mycobacterium tuberculosis Rv3378c and DPPS (ζ fold), and the …
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SCREENING AND IDENTIFICATION OF NEW FOOD DERIVED PEPTIDES WITH MULTI-TARGET CHOLESTEROL-LOWERING ACTIVITY
… metabolic pathways by binding or inhibiting targeted receptors. This modulation can lead to positive effects on metabolic diseases, making it particularly noteworthy because it aligns with the trend of many individuals seeking healthier lifestyles through dietary management rather than …
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Synthesis and evaluation of novel multi-target compounds for the treatment of Alzheimer's disease.
… urgent unmet need for a cure. AD is a complex, multifactorial disease and therefore the multi-target strategy is considered to be a promising approach to drug development for this disease. The aim of this work was to design and synthesise novel hybrid compounds with the potential to be applied …
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Advancing sepsis treatment: synthesis and evaluation of multi-target drugs with antimicrobial, antioxidant and anticoagulant properties.
… clinical nature of sepsis renders single-target therapies, such as antibiotics, fluid resuscitation and vasopressors, ineffective in many cases. This project aims to develop a series of multi-target drugs (MTDs) to address the various pathologies of sepsis, specifically targeting …
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Viewpoint-Aware Task Planning and Model Predictive Control for Applications in Videography and Multi-Target Tracking
… to solve a variety of viewpoint-constrained target following tasks. In the scenarios we consider, a team of tracking agents is desired to gain some sort of visual information about one or more target agents. A high level planning algorithm accounts for coarse, global decisions, such as “Which …
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Development and evaluation of a new biochip Nucleic Acid Test (NAT) multi-target for cervical cancer screening
… of the viral genome (L1 and E6/E7 sequences) as targets. This report also presents the results of a preliminary validation study in preparation for an extended clinical validation of the medical diagnostic ProDect® CHIP HPV TYPING PLUS employing the above CHIP PLUS designed both for the …
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Investigation into the effects of chromium cross-contamination in niobium sputter deposited coatings using a multi-target PVD system.
… prior to deposition and can involve the use of a target for this stage that is not required during the coating process. During deposition to prevent unused targets becoming coated a negative potential is applied to the cathodes. As a result, due to the lack of individual target shutters, the …
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