Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Multi-compartment"”.
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Active geometric model : multi-compartment model-based segmentation & registration
… model, proposed for concurrent segmentation of multiple objects embedded in the same image domain. We also propose a novel shape descriptor, namely the Multi-Compartment Distance Functions or mcdf. Our proposed framework for segmentation is two-fold: first, several training samples distributed …
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Probabilistic Multi-Compartment Deformable Model, Application to Cell Segmentation
… the relative topology of the two distinct cell compartments to derive a better segmentation and compensate for the lack of edge information. The framework is applied to static fluorescent microscopy, where the cultured cells are stained with calcein AM.
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Measuring spatially varying elastic modulus of multi-compartment 3D collagen scaffold using indentation
Collagen scaffolds with discrete mineralized and non-mineralized regions that are joined by a continuous interface offer great potential for generating a platform with spatially variant stiffness. Once such platforms are seeded with cells, they have been shown to significantly influence cell …
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Differential human mesenchymal stem cell responses across multi-compartment scaffolds for tendon-bone regeneration
… mineralized and non-mineralized CG scaffold compartments. Fabricated via lyophilization, we explore use of diffusion-based approaches to form the gradient interface. We also describe an approach to create an interdigitated interface, and showed composite elastic modulus and failure load …
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The multifarious self-assembly of triblock copolymers : from multi-responsive polymers and multi-compartment micelles
… lipophilic and fluorophilic domains – so called multi-compartment micelles. The association of triblock copolymers in water was studied by 1H NMR spectroscopy, DLS and cryogenic transmission electron microscopy (cryo-TEM). Direct imaging of the polymeric micelles in solution by cryo-TEM revealed …
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Petroleum development optimization under uncertainty : integrating multi-compartment tank models in mixed integer non-linear programs
… project drivers. The model can be used to screen multiple concepts to arrive at a few promising concepts that point the direction for detailed studies. The application of the model is demonstrated with synthetic cases formulated for a deep water field which is at the concept selection phase. In …
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Enhancement of spatially-controlled MSC responses in a multi-compartment CG scaffold for tendon-bone junction regeneration
There have been many advancements in the field of tissue engineering for the repair or regeneration of single tissues. However, orthopedic injuries often occur at the interface between soft tissues and bone. The tendon-bone junction (TBJ) is a classic example of such an interface, containing …
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ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΑΞΙΟΠΙΣΤΙΑΣ ΙΣΟΔΥΝΑΜΩΝ ΠΛΑΙΣΙΑΚΩΝ ΠΡΟΣΟΜΟΙΩΜΑΤΩΝ ΓΙΑ ΠΥΡΗΝΕΣ ΠΟΛΥΟΡΟΦΩΝ ΚΤΙΡΙΩΝ ΥΠΟ ΟΡΙΖΟΝΤΙΑ ΦΟΡΤΙΣΗ
… BEAMS, CLOSED SECTION CORES WITH SINGLE OR MULTI-COMPARTMENT) OF QUASI-STATIC SEISMIC LOADING (SYMMETRIC, PURE TORSIONAL AND ECCENTRIC). IN THE SECOND STAGE, A MIXED SPACE STRUCTURE IS INVESTIGATED WITH AN ECCENTRICALLY LOCATED MULTI-COMPARTMENT CORE UNDER HORIZONTAL LOADING. IN THIS CASE, …
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Assessment of magic angle spinning spectroscopy for studying migration in solid milk chocolate
… individual chemical signals and demonstrated multi-compartment diffusion behavior.
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Development of collagen scaffolds to address biomechanical design criteria for tendon–to–bone repair
… Although current methods are moving towards multi-tissue regenerative approaches to address these injuries, it remains a challenge to fully characterize local mechanical and cellular heterogeneities within a single biomaterial using traditional techniques. Herein we describe a variety of …
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Quantifying the pathways modulated by deep brain stimulation for essential tremor using computational modeling
… implanted with a Medtronic 3389 DBS lead. Multi-compartment models of Vim / Vc thalamocortical neurons and cerebellothalamic / medial lemniscal axonal afferents were simulated in the context of patient-specific anatomies, lead placements, and programming parameters. Complete suppression of …
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Design, characterization, and reinforcement of mineralized collagen-glycosaminoglycan scaffolds for orthopedic wound repair
… and subsequent characterization of a multi-scale polycaprolactone-collagen-glycosaminoglycan composite biomaterial for in vivo implantation and culture. In chapter 5 the polycaprolactone-collagen-glycosaminoglycan composite was then implanted in a subcritical mandibular ramus defect to …
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Optical imaging of dendritic spikes in apical oblique dendrites of layer 5 pyramidal neurons
… regions to function as independent computational compartments. While there is a wealth of information about cortical processing in apical tuft and basal dendrites, the functional role of apical oblique dendrites of layer 5 pyramidal neurons (L5PNs) are less understood. In this thesis, I aim to …
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Optical imaging of dendritic spikes in apical oblique dendrites of layer 5 pyramidal neurons
… regions to function as independent computational compartments. While there is a wealth of information about cortical processing in apical tuft and basal dendrites, the functional role of apical oblique dendrites of layer 5 pyramidal neurons (L5PNs) are less understood. In this thesis, I aim to …
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The influence of collagen-GAG scaffold architectural and biological cues on tenocyte and mesenchymal stem cell bioactivity for musculoskeletal tissue engineering
… application of this knowledge to the design of a multi-compartment scaffold for engineering the TBJ. The studies here use collagen-glycosaminoglycan (CG) scaffolds, regulatory compliant analogs of the native ECM that have been applied to the regeneration of dermis, peripheral nerve, and …
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Scale-Up of Latex Reactors and Coagulators: A Combined CFD-PBE Approach
… was modified to communicate directly with a multi-compartment PBM. The hybrid framework was shown to be well-suited for modeling the controlled coagulation of high solid content latexes in the laminar regime. It was found that changing the size of the reactor affected the latex PSD obtained …
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Development of a novel hybrid field and zone fire model
… incurred in using field models to simulate multi-compartment geometries, and it will be implemented to allow users to employ the zone component without having to make further technical considerations, in line with the existing paradigm of the SMARTFIRE suite. In using the hybrid model only …
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Methodologies to strategize the utilization of modeling and simulation for probabilistic risk assessment (PRA) of nuclear power plants: Applications in fire PRA
… the degree of realism for simulation models as a multi-criteria decision problem. It considers two primary decision attributes: the anticipated impact on the plant risk estimates and the projected resources needed for the analysis. This decision-making process involves determining the appropriate …
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