Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 213 for “"Modulatory"”.
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Modulatory effects of GluN1 autoantibodies on brain function
Over the last two decades, building evidence has shown that antibodies in the peripheral circulatory system are able to cross the blood-brain-barrier (BBB) and enter the central nervous system (CNS) to modulate brain function, as supported by findings in vaccination strategies for Alzheimer’s …
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Immuno-modulatory functions of CD1d-restricted natural killer T cells
This thesis focuses on a small population of non-conventional T lymphocytes, called natural killer T (NKT) cells. NKT cells have many unique features; such as recognition of glycolipids presented by CD1d, expression of NK receptors and rapid production of large amounts of cytokines, such as IL-4 …
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Integrate-and-fire modelling of neuronal systems with modulatory properties
The mathematical modelling of behaviour at the single neuron level is an important part of computational neuroscience. Conductance-based models remain dominant because of their biophysical interpretation. Nevertheless, their high dimensionality and number of parameters complicate mathematical …
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Investigating the immune modulatory properties of kisspeptin: implications for pregnancy
… response of the mother, emphasizing their immunomodulatory effects. Therefore, hormonal regulation is essential for the functional activity of immune cells. There is evidence that the hormone, kisspeptin, plays a role in the development of immune tolerance during pregnancy based on its role in …
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REGRET AS A MODULATORY SYSTEM: HOW IMAGINED FUTURES BECOME REAL PASTS
The goal of this research was to empirically test a proposed theory that was developed to explain how humans simulate future undesirable outcomes, evaluate their past behaviors, and potentially grow from these experiences through anticipated and retrospective regret. Using a longitudinal design, we …
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The Octopaminergic Modulatory Circuitry of the Drosophila Larval Mushroom Body Calyx
How are neuromodulatory networks organised to adapt sensory discrimination for different contexts? I hypothesised that neurons within a sensory circuit express different neuromodulatory receptors for differential modulation. Here I aimed to use the simple and genetically amenable Drosophila larval …
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Modulatory Effects of Citrus Flavonoids Towards the Metabolism and Mutagenicity of Environmental Carcinogens
<p>The environmental carcinogens classified as heterocyclic amines (HCA’s) and the tobacco-specific nitrosamine NNK generally require internal enzymatic activation. This activation occurs via cytochrome P450 (CYP) enzymes and leads to metabolites that bind to human DNA which may in turn cause …
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The Immune Modulatory Effects of Tylvalosin in Porcine Neutrophils and Macrophages in vitro
Tylavlosin (TYL), a veterinary macrolide antibiotic, has been reported to have superior efficacy treating bacterial infections of the respiratory tract in swine. This study aims to characterize potential pro-resolving of tylvalosin benefits in a porcine model by elucidating its effects, in isolated …
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Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
Rift Valley fever Phlebovirus (RVFV) ist ein Mitglied der Familie Bunyaviridae. Es wird durch Stechmücken übertragen und ist in der Lage zahlreiche Wirtspezies zu infizieren. Beim Menschen kann die Infektion zu Hepatitis, hämorrhagischem Fieber und Enzephalitis mit tödlichem Ausgang führen. Bei …
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Antimicrobial and immuno-modulatory peptides as a treatment for lung disease and delivery by nebulisation
… due to their antimicrobial and/or immunomodulatory properties. The project aim was to assess the therapeutic potential of several snake-derived AMPs and to evaluate the suitability of peptide delivery by nebulisation.<br/><br/>In in vitro assays the peptides exhibited antimicrobial …
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Harmful effect of oxysterols in the gut and at systemic level: modulatory activity of olive oil phenolics
A healthy and proper diet is essential to prevent the onset of various diseases, as with the diet we can also introduce harmful substances. Among others, the oxysterols are particularly relevant; they can be absorbed from the diet and are the oxidized products of cholesterol present in …
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Cross-Modulatory Actions of Estrogen Receptor Beta on Estrogen Receptor Alpha Transcriptional Activity in Breast Cancer Cells
Our observations indicate that the ability of ERalpha and ERbeta to serve as determinants of gene expression is greatly influenced by the nature of the ligand, ligand dose, and the ability of ligand-ER complexes to recruit coregulators at ER binding sites of hormone-regulated genes.
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HcpE, a potential immuno-modulatory protein from Helicobacter pylori that is dependent on the Disulfide bond protein DsbHP
H. pylori is a human gastric pathogen that colonizes ~ 50% of the world’s population. It can cause gastritis, gastric or duodenal ulcers and also gastric cancer. H. pylori produces Helicobacter cysteine rich protein HcpE, a secreted protein which may play a role in virulence. In this study we show …
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Evaluation of biomass from the halotolerant microalga Dunaliella salina as an animal feed additive with immune-modulatory activity
The work presented in this thesis sought to evaluate the potential of microalgal biomass sourced from Dunaliella salina for use as an animal feed additive. Dunaliella salina is the richest known source of carotenoid pigments and anti-oxidants, and these have a variety of uses including as food …
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Cross-modulatory Actions of Cell Cycle Machinery on Estrogen Receptor-alpha Level and Transcriptional Activity in Breast Cancer Cells
Breast cancer is one of the most highly diagnosed cancers in women and the second largest cause of death of women in United States. The anti-estrogen tamoxifen which blocks gene expression through estradiol bound ERα, and hence the growth stimulatory effects of estradiol, has been widely used for …
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A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
… virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical …
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Modulatory effect of EVOO polyphenols and their metabolites on inflammatory response in Adenocarcinoma Colon Cells (Caco-2) and Human Umbilical Vein EC (HUVEC)
… LPS and/or a hyperglycemia (HG) condition. Their modulatory action was evaluated focusing on the alteration of tight junctions (TJ) and the activation of cellular pathways, as mitogen-activated protein kinases (MAPK) and NLRP3 inflammasome, which are linked to chronic inflammatory diseases. The …
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Cell-selective modulation of the neuromuscular system in Drosophila
… molecules used throughout the animal kingdom are modulatory substances (e.x. hormones and peptides). Modulators can act as chemical transmitters, facilitating communication at chemical synapses. There are hundreds of circulating modulators within the mammalian system, but the reason for so many …
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