Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Mitomycin C"”.
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Zellzykluseffekte von Mitomycin C
ZELLZYKLUSEFFEKTE VON MITOMYCIN C Im Rahmen dieser Arbeit sollten die durch Mitomycin C (MMC) exogen induzierten Zellzyklusstörungen mit den endogenen Störungen des Zellzyklus bei Fanconi-Anämie in unterschiedlichen Zellsystemen (periphere Blutlymphozyten, lymphoblastoide Zellen und Fibroblasten) …
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Synthesis of optically pure mitomycin C: A new route to FR900482
Optically pure mitomycin C was synthesized in 28 steps and 5% overall yield from 2,6-dimethoxytoluene. The route followed was a variation upon previous work in our laboratories and the asymmetry was achieved by the resolution of racemic mitomycin A, an advanced intermediate. Our efforts at finding …
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Effect of Mitomycin C with different application method on rabbit corneal wound healing process after Excimer laser photortherapeutic keratectomy
We investigated the effect of Mitomycin C with different application method on corneal haziness and keratocyte proliferation after Excimer laser phototherapeutic keratectomy in rabbit. PTK was performed in both eyes of 18 New Zealand white rabbits using Technolas 217™. After laser removal of the …
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DNA repair in Bacteroides fragilis Bf-2
… followed by selection for sensitivity to mitomycin C. One mutant (UVS9) showed sensitivity to both mitomycin C and far-UV irradiation. The other (MTC25) was more sensitive to mitomycin C than UVS9, but showed wild-type resistance to UV radiation. Both mutant strains had wild-type …
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근치적 수술을 시행받은 국소진행성 위암환자에서 정주 면역항암화학요법과 경구 면역항암화학요법의 제 3상 임상연구
… 수술을 시행받은 위암환자에서 보조 항암요법으로서 정주 5-fluorouracil, mitomycin-C 및 polysaccharide-K 면역항암화학요법과 경구 UFT 및 polysaccharide-K 면역항암화학요법을 무작위 배정하에 시행하여 전체 생존율, 무병 생존율, 독성을 비교한다. 방법: 2002년 5월부터 2005년 10월까지 아주대학교 병원에서 근치적절제술을 받은 American Joint Committee on Cancer (AJCC)에서 지정한 병기 IB-IIIB의 위암환자들을 …
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Elucidating how mutations in EIF2AK4 cause pulmonary vascular disease
… of interleukin 6. Since the chemotherapy drug mitomycin-c can also induce PVOD in humans I decided to create an orthogonal model of PVOD by exposing wild-type mice to mitomycin-c. These mice also demonstrated right ventricular remodelling, which was prevented by genetic ablation of interleukin …
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Development of a Genetic Modification System in <i>Clostridium scatologenes</i> ATCC 25775 for Generation of Mutants
… were exposed to an effective concentration of mitomycin C at 2μg/ml and 5μg/ml. Induction with temperature was performed at 42ºC and 55ºC. Bacteriophage liberation, determined by a decrease in optical density was not observed in response to mitomycin C or by different growth temperatures. …
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Human embryonic stem cells for genotoxicity testing
… analysis by PNA-FISH and mFISH following Mitomycin C treatment revealed that hESCs are significantly more resistant to genotoxic damage than normal human fibroblast cell line as evidenced by the lower levels of chromosomal aberration in hESCs. The resistance of hESCs to genotoxic damage …
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The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice
… different chemotherapeutic agents, cisplatin and mitomycin-C.
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Hemmung der humanen Telomerase Reverse Transkriptase-Expression mittels synthetischer Nukleinsäuren in Harnblasenkarzinomzellen
… das BCa relevanten Chemotherapeutika Cisplatin, Mitomycin C und Gemcitabin signifikant verstärkt werden. Nach Untersuchung der AS-ODN-Wirkung in vitro erfolgte die Etablierung eines subkutanen Xenotransplantantmodells der Nacktmaus. Die Eignung einer intraperitonealen Applikation wurde mit …
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Metabólitos produzidos por Streptomyces spp. com atividade antitumoral.
… daunorubicin, dactinomycin, retamycin, mitomycin C, antibiotics are commonly used to treat many types of cancers. These drugs must eradicate cancer cells, and the advantages of its use are to be compared with the cardiotoxicity caused mainly to patients undergoing chemotherapy or after …
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The impact of cytotoxic chemotherapy on somatic mutation in normal human cells
… include SBS signatures associated with mitomycin C, lomustine/carmustine, busulfan and thiotepa, alongside a DBS signature of mitomycin C and an indel signature associated with a broad range of platinum-based and alkylating agents. Additionally, indel signatures of topoisomerase II …
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Stammdesign in B. licheniformis
… zeigte eine erniedrigte Sensitivität gegenüber Mitomycin C, das für die Induktion von lysogenen Phagen eingesetzt wird. Darüber hinaus konnten auch keine Phagenpartikel mehr identifiziert werden. Für ein Wachstum auf Harnstoff wurde der Urease-Gen-Cluster aus B. licheniformis 9945A auf den …
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Mosaikbildung bei Fanconi-Anämie
… nach Behandlung mit Diepoxybutan oder Mitomycin C oder durch einen erhöhten Anteil von Zellen in der G2-Phase in der Durchflußzytometrie. Bei einigen Patienten wurden Verläufe mit stabilen Blutbildern beschrieben. Als Erklärung wurde das Vorhandensein einer Mosaikkonstellation bei …
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Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane
… adjuvant intravesical<br/>chemotherapy using mitomycin C or epirubicin (an anthracycline), following<br/>surgical resection. However, despite this treatment, the recurrence rates of<br/>these tumours can approach 60%. This high recurrence rate represents the<br/>development of MDR in many …
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Does the Timing of Adjuvant Chemotherapy for Gastric Cancer Influence Patient Outcome?
… of 410 patients who underwent 5-fluorouracil/mitomycin-C/polysaccharide-K adjuvant chemotherapy for stage IIA-IIIC gastric cancer after curative resection. Overall survival (OS) was compared among patients grouped by time from surgery to start of adjuvant chemotherapy. RESULTS: The median time …
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ALKBH3 and FTO: New Epitranscriptomic Regulators of DNA Double-Strand Break Response
… FTO og RNF168 auki næmi gegn meðferðarlyfjunum Mitomycin C og Neocarzinostatin. Þá þykir áhugavert að frumur sem skortir ALKBH3 sýna fram á ónæmi gegn meðferð með PARP hindrum, tegund markvissrar krabbameinsmeðferðar sem hefur verið notuð gegn krabbameinum sem hafa galla í endurröðunarviðgerð. …
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A Study of genetic instability and DNA repair in selected mutants of streptomyces cattleya
… the basis of their resistance or sensitivity to Mitomycin c. Of the three mutants, two, R6 and Rl2, were selected as MMC resistant and one, S26, as MMC sensitive. They were also UVr and UVˢ, respectively. The mutants were subjected to UV irradiation in order to obtain UV kill curves. The curves …
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Towards Phage Therapy: Characterization of Clostridioides difficile Bacteriophages from a South African Strain Collection
… defence systems. Phage induction was done using mitomycin C in liquid cultures and plaque overlay assays. Attempts were made to purify phages and generate PCR amplicons for sequence confirmation. The results of this study demonstrate the presence of phages in local C. difficile isolates and …
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Regulatory pathways controlling cell division after DNA damage in Caulobacter crescentus
… defect in the presence of the DNA damaging agent mitomycin C (MMC). This finding suggests that some degree of redundancy exists within the Caulobacter response to MMC. Finally, I describe ongoing experiments which explore the origins of the SOS-independent induction of didA.
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