Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 141 for “"Midline"”.
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Midline Catheter Usage in the Neonatal Population
… (VAD). Literature reviewed demonstrated that a midline catheter (MC) was an option for a VAD with neonatal populations requiring antibiotic therapy more than 48 hours. MCs offer fewer complications compared to the peripheral intravenous (PIV) device. The objective of this project is to reduce …
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… and roundabout mutants investigated how abnormal midline decisions affect subsequent growth cone pathfinding. Results showed that despite abnormal decisions at the midline, subsequent pathways and synaptic targeting in all cases were the perfect mirror-images of those seen in wildtype. This …
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Sema-1a Reverse Signaling Promotes Midline Crossing In Response To Secreted Semaphorins
… step in proper guidance involves crossing the midline, and failure to do so often results in an inability to coordinate movement. Attraction to the midline depends in part on the highly conserved guidance receptor DCC, or Frazzled in Drosophila, which signals chemoattraction upon binding its …
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Midline Movement: The Positive Effects on Student Behavior in a Kindergarten Classroom
… how movements and activities that cross the midline affect a student's focus and ability to learn in the classroom. Cultivating an understanding of the importance of midline movements in the classroom is important to create buy-in for schools and teachers to join this movement. In turn, …
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Radial glia in the developing superior colliculus : evidence for a midline barrier
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1991.
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AUTOMATED MIDLINE SHIFT DETECTION ON BRAIN CT IMAGES FOR COMPUTER-AIDED CLINICAL DECISION SUPPORT
Midline shift (MLS), the amount of displacement of the brain’s midline from its normal symmetric position due to illness or injury, is an important index for clinicians to assess the severity of traumatic brain injury (TBI). In this dissertation, an automated computer-aided midline shift estimation …
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Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling
<p>Diffuse Midline Gliomas (DMG) occur in the midline structures of the brain such as the brainstem. DMG, a subset of pediatric high-grade gliomas (pHGGs), confers poor prognosis in children with survival rates below two years post-diagnosis. This is heavily due to limited treatment options as …
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Left, Right, and Center: A Novel Midline Barrier Separates Asymmetric Extracellular Matrix During Intestinal Development
… The early embryo requires a Lefty1-positive midline barrier to specify the left-right body axis, without which embryos suffer lethal or congenital patterning defects. Many individual organs also have left-right asymmetry, but only the brain has a known mechanism for separating the two sides. …
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Axo -Dendritic Midline Guidance, Early Polarity and Dendritic Development in Embryonic Motoneurons of Drosophila Melanogaster
While it has been observed that neurons are cells that are polar and connected, the growing work in dendritic guidance leads to the questions regarding the possibility that these two developmental endpoints are interrelated.
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Netrin Guides Spinal Commissural Axons to the Midline at Long Range Through the Receptors Dcc and Neogenin
… commissural axons are guided to the ventral midline in a remarkably precise and stereotyped way. Netrin, a secreted laminin-related protein, provides the major attractive cue for midline guidance. It is thought to act at long-range, functioning either in solution (chemotaxis) or bound to …
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Automated Measurement of Midline Shift in Brain CT Images and its Application in Computer-Aided Medical Decision Making
… brain images to automatically calculate midline shift in pathological cases and use it to predict Intracranial Pressure (ICP). The midline shift measurement can be divided into three steps. First the ideal midline of the brain, i.e., the midline before injury, is found via a hierarchical …
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Variation of the Administration of the WISC-III Block Design Subtest
… materials were aligned with the participant's midline. In the Side condition, the stimulus materials were placed 1.5 inches (3.81cm) off of midline. The results of an ANCOVA with prior experience with the subtest scaled scores. However, results of a repeated-measures ANCOVA with experience as …
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Intraoperative and Postoperative Analgesia with TAP-Block in Patients with Lower Midline Laparotomy // Интраоперативно и постоперативно обезболяване с TAP-block при пациенти с долна срединна лапаротомия
Ефективният контрол на болката в периоперативния период е съществен фактор за общия успех от хирургичното лечение и удовлетвореността на пациента. По тази причина обезболяването е основна част от лечебния процес, а регионалните техники навлизат все по-широко. Цел на проучването е да оценим …
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Postembryonic Polarity Modification in the Acoel Convolutriloba longifissura
… have elucidated the temporal dynamics of midline re-specification, suggesting that parallel L-R axes replace the pre-existing midline prior to longitudinal fission. We have characterized the spatiotemporal expression of genes encoding ligands and receptors of signaling pathways with …
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The <i>Drosophila</i> T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival
… melanogaster </em>T-box transcription factor <em>midline (mid)</em>, a homolog to the human <em>TBX20 </em>gene, interacts with <em>dFOXO </em>within the insulin receptor (InR) and the c-Jun-N-terminal kinase (JNK) signaling pathways to regulate interommatidial bristle (IOB) formation. Previous …
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The Role of Cell Division Orientation during Zebrafish Early Development
… we show that SDO is required for neural rod midline formation during neurulation, but dispensable for body axis elongation during gastrulation. Our data indicate that SDO during both gastrulation and neurulation is dependent on the non-canonical Wnt receptor Frizzled 7 (Fz7), and that …
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Signal Transduction Mechanisms in Commissural Axon Guidance: The Role of Intracellular Tyrosine Kinases in Netrin-Dcc/Frazzled Axon Attraction
… axon guidance cue, Netrin. Netrin elicits midline axon attraction in all bilaterally symmetric animals studied to date through the DCC family of receptors. In Drosophila, commissural neurons require Netrin and its DCC receptor, Frazzled, for midline axon crossing. To identify genes that …
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Balancing growth and repulsion: Slit proteolysis generates diverse signals in axon guidance
… identified as repellents of CNS axons at the midline, the medial separation of the left and right sides of the body. In the absence of Slits, all CNS axons collapse onto the midline. The repulsion conducted by Slits is essential to maintain separation of axons on the left and right sides of …
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Mummy regulates slit-robo signaling to mediate axon guidance in drosophila embryonic nerve cord
… mechanism. Slit is a chemo-repellant secreted by midline glial cells and binds to specific receptor Roundabout to mediate axonal repulsion. However, molecules involved in finer regulation of this pathway are unknown. I used the Drosophila embryonic nervous system as an experimental model to study …
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The Intracellular Domain of the Frazzled/Dcc Receptor is a Transcription Factor Required for Commissural Axon Guidance
… axon responsiveness to the embryonic ventral midline. In Chapter 1, I introduce the embryonic ventral midline as a model system for studying how axons modulate their responsiveness to guidance cues at intermediate targets and I discuss mechanisms through which DCC transduces signals from its …
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