Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 112 for “"Microsphere"”.
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Scaleable nanomanufacturing of metasurfaces using microsphere photolithography
… issue that limits their implementations. Microsphere photolithography (MPL) uses a scalable self-assembled microsphere array as an optical element to focus collimated light to nanoscale photonic jets in a photoresist layer. This dissertation investigates the fabrication capabilities, …
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DEVELOPMENT OF NON-CONTACT MICROSPHERE CONFOCAL SCANNING MICROSCOPE
… a novel technique, called the non-contact microsphere confocal scanning microscope, is proposed and developed. This setup can enhance the lateral resolution to 110 nm, the axial resolution to 100nm and image contrast to 71%, while retaining the key features of the conventional confocal …
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Calibration of an optically levitated microsphere as a force sensor
By using an optically trapped and cooled microsphere (bead) as a force sensor, it is predicted to be possible to attain force sensitivity of 10-21 N[1]. This sensitivity is achieved because the force sensor is mechanically decoupled from the environment, which allows for larger quality factors. …
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Design and Implementation of Position-Encoded Microfluidic Microsphere-Trap Arrays
… discovery. In this dissertation, we consider a microsphere array device with predetermined positions of the microspheres. The microspheres are conjugate on their surfaces with molecular probes to capture the targets, and the targets are identified by the microspheres' positions. We implement the …
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Integration of glass microspheres and planar waveguides for microsphere lasers
Microsphere resonators with sizes in the micrometer range are reported to support very high Q’s of more than 10<sup>9</sup> for a fused silica microsphere. This high Q value represents many promising characteristics such as low cavity loss, long cavity life time, and narrow band width. With their …
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Phase Behavior, Structure, and Properties of Colloidal Microsphere-Nanoparticle Mixtures
… binary mixtures of negligibly charged colloidal microspheres were studied for two size ratios of 95 and 197 at pH = 1.5. In the absence of nanoparticle additions, the system spontaneously assembled into a colloidal gel whose strength increased with microsphere volume fraction. Between a lower and …
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Mechanical And Computational Evaluation Of Cementitious Materials With Hollow Glass Microsphere Inclusions
… by an inert filler known as hollow glass microspheres on elastic properties is evaluated in this study through a combined computational and experimental approach. This approach considered the variation in properties of type I Portland cement for 0, 5, 10, and 15% volume fractions of two …
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Markov-Airy method for electromagnetic fields in layered structures and microsphere-stabilized planar resonators
… of constructing a cavity is demonstrated. A microsphere is placed in between two high-reflecting mirrors. Depending on the separation of the mirrors, the spheres were observed to either lower or raise the lasing threshold. Models of the cavity were developed and agree with observed data. By …
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Intratumoral holmium-166 microsphere injection in pancreatic cancer: Starting to treat from the inside out
Contains fulltext : 331040.pdf (Publisher’s version ) (Closed access)
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DEVELOPMENT AND KINETIC MODELING OF MULTIPLEX MICROSPHERE ASSAYS FOR HIGH-THROUGHPUT DISCOVERY OF PROTEASE ACTIVE SMALL MOLECULE COMPOUNDS
… which can be associated with streptavidin-coated microspheres/nanospheres. We have developed microsphere-based platforms to detect the cleavage activities of several proteases simultaneously. In addition, we have performed high-throughput screening (HTS) to identify potential inhibitors for the …
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Luminex Microsphere Immunoassay Offers an Improved Method in Testing for Antibodies to Eastern Equine Encephalitis Virus in Sentinel Chicken Sera
… initial screening result in the HAI tests. The Microsphere Assay Technology provides an accurate, more rapid (a day or two instead of a week or more) detection method including both a screening and confirmation protocol specifically designed to test for antibody to EEE in sentinel chicken sera. …
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Ex-Vivo Injection of Biomaterial Biologics for Treatment of Osteonecrosis
… The purpose of the study was to maximize microsphere distribution in an ex vivo humeral head osteonecrosis model. The hypothesis was that bone washing, smaller microsphere size, higher microsphere concentration, hydrogel carrier, larger inter-needle distance, and increased needle number …
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Computational and Experimental Studies of Controlled Release Drug Delivery: Effect of Microsphere Diameter and Drug Size on in-Vitro Release Kinetics
Overall, the several ways microsphere size affects small-molecule, protein and oligonucleotide release have been clarified in this work.
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Investigation of properties affecting controlled release of macromolecules from PLGA microspheres
Poly(lactide-co-glycolide), or PLGA, microspheres offer a widely-studied biodegradable option for controlled release of therapeutics. An array of fabrication methodologies have been developed to produce these microspheres with the capacity to encapsulate therapeutics of various types; and produce …
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Development of a Fluorescence Microsphere Immunoassay for Detection of PRRSV Infection Using Oral Fluid Samples as an Alternative to Serum-based Assays
… study, we developed a multiplexed fluorescence microsphere immunoassay (FMIA) for detection of PRRSV specific antibodies in oral fluid and serum samples. Recombinant nucleocapsid protein (N) and nonstructural protein 7 (nsp7) from both PRRSV genotypes (Type I and Type II) were used as antigen …
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DOSIMETRIC STUDY OF BETA-MINUS EMITTER PRASEODYMIUM-142 : APPLICATIONS IN MICROSPHERE BRACHYTHERAPY FOR HEPATOCELLULAR CARCINOMA AND BRACHYTHERAPY FOR OCULAR SQUAMOUS CELL CARCINOMA
… of this source in brachytherapy are proposed: microsphere brachytherapy and eye plaque brachytherapy. ¹⁴²Pr (96.3% beta and 3.7% gamma) has recently gained increased attention among beta sources for therapy. Its inherent physical and dosimetric characteristics may be suitable for several …
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Nanoparticle Engineering of Colloidal Suspension Behavior
… behavior, structure, and assembly of colloidal microsphere suspensions. Specifically, by selectively tuning the electrostatic interactions between silica microspheres and polystyrene nanoparticles, we study the behavior of four key systems: (i) strongly repulsive, (ii) haloing, (iii) weakly …
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Resonant Detection of Nano to Microscopic Objects Using Whispering Gallery Modes
… trajectory circumnavigating just below the microsphere surface. Whenever the light ray tries to escape it is sent back on its circular path by total internal reflection. The light orbit closes in on itself several thousand times and thus creates an optical resonance. The unprecedented narrow …
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Investigation of protein destabilization in monodisperse poly(lactide-co-glycolide) microparticles
Poly(lactide-co-glycolide) (PLG) microspheres are a powerful choice for controlled release of protein therapeutics. However, several properties of PLG microspheres, particularly hydrophobicity and acidic microenvironment, may have detrimental effects on encapsulated protein, causing structural …
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Toward a demonstration of a Light Force Accelerometer
… laser beams optically confines a glass microsphere. Inertial acceleration of the device results in microsphere displacement along the sensitive axis, which is subsequently nulled by optical forces to provide an acceleration measurement. A simple calculation that takes into account …
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