Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Microneedle"”.
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Optimisation of microneedle array design for microneedle mediated iontophoretic transdermal drug delivery
… recently been suggested that a combination of microneedle (MN) and iontophoresis (ITP) technologies may broaden the range of macromolecules that may be successfully delivered across the skin, with the added benefit of precise electronic control over the rate of transdermal drug delivery. MNs …
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Advanced Electrohydrodynamic Atomisation Engineered Microneedle Coatings
… to conventional methods (oral and parenteral). Microneedle (MN) based devices have gained significant interest as a strategy to overcome the skins formidable barrier; the stratum corneum and enhance drug delivery. The research presented here shows the successful coating of MNs with polymeric dye …
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Microneedle gastric retention for drug delivery
… to inject macromolecules in the GI tract using microneedles that can implant themselves in the stomach lining; however, they do not provide long-term drug delivery. To create a controlled release micro injection, I hypothesize that a hooked needle will latch onto the muscularis mucosae layer in …
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Microneedle-mediated transdermal drug delivery of biotherapeutic macromolecules
… required for crossing the human skin barrier. Microneedle (MN) technology combines micro-engineering and material sciences to fabricate micron scale projections manufactured onto a platform. That, when pressed against the skin, create aqueous apertures allowing drug delivery directly into the …
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Polymeric microneedle systems for enhanced transdermal drug delivery
… and reduction of systemic side effects. Microneedle (MN) are minimally-invasive devices that painlessly by-pass the skin's stratum corneum, which is the principal barrier to topically-applied drugs.<br/><br/> Polymeric MN delivery systems were designed and evaluated to transdermally …
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Engineering a microneedle patch for opioid overdose therapy
… In this work, we developed a minimally invasive microneedle (MN) patch system using gelatin methacryloyl (GelMA) hydrogels to enable sustained transdermal delivery of naloxone. Microneedle arrays (10×10, 600 µm height, 500 µm pitch) were fabricated with tunable UV crosslinking (0s, 15s, 30s, 60s) …
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Development of antibiotic microneedle delivery systems for tuberculosis treatment
… a novel approach, using hydrogel-forming microneedle (MN) arrays to transdermally deliver TB drugs, namely rifampicin, isoniazid, pyrazinamide and ethambutol, which have different physicochemical properties. These drugs were individually prepared into three types of drug reservoirs, …
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Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs
… could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system through the skin, thus avoiding first pass metabolism and allowing more focused delivery to specific viral or bacterial …
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Microneedle array patches for skin hyperthermia and enhanced intradermal drug delivery
Microneedles (MN) arrays are micron-size needle arrays with length generally ranging between 50 μm and 2 mm. When applied to the skin surface, they pierce the stratum corneum creating micropores that can enhance the delivery of drugs into the viable skin layers. MN arrays offer great advantages for …
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Controlled release microneedle technologies for the enhanced immunogenicity of subunit vaccines
… is to complete a one-time application of a microneedle device to the skin that controllably releases the vaccine to mimic this exponential pattern to manipulate the immune system into providing strong humoral and cellular mediated protection. A number of different novel microneedle …
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Design and fabrication of a microneedle for the implantation of floating microstimulators
… focuses on the design and fabrication of a microneedle that will have the capability of penetrating the neural tissue and delivering floating microstimulators pumped out by fluid through a microfluidic channel
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Dissolvable microneedle manufacturing methods and the application of three-dimensional printing to pharmaceuticals
Dissolvable microneedles are an intradermal drug delivery technology with exciting potential for widespread distribution of minimally invasive, self-administered medicines and vaccines. The most popular manufacturing method for medical dissolvable microneedles is micromoulding, a process which can …
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Evaluation of polyelectrolyte multilayer thin-film coated microneedle arrays for transcutaneous vaccine delivery
… a polyelectrolyte multilayer thin film-coated microneedle platform that can achieve simultaneous DNA and nanoparticle delivery. This delivery platform has the advantage of direct delivery of DNA or polymer nanoparticles to immune-active cells at the interface between the dermis and epidermis, …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… in the skin in a high level and long-acting way. Microneedles are a novel drug delivery technology that increase skin permeability by creating microscopic pores within the skin, thereby reducing the barrier to drug permeation. This thesis focuses on developing the novel polymeric microneedle …
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Development of a Hollow-Core Fiberoptic Microneedle Device for the Treatment of Invasive Bladder Cancer
… early development of the hollow-core fiberoptic microneedle device (FMD). The study determined that for straight tubing with an inner bore of 150 ?m and a length greater than 50 mm long, Poiseuille's Law was shown to be accurate within 12% of experimental data for the pressure range of 69-517 …
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Thermotherapeutic enhancement of infusate distribution during convection enhanced delivery in the brain using fiber-optic microneedle devices
… bypassing the blood brain barrier. A fiberoptic microneedle device (FMD) CED catheter enables simultaneous delivery of laser energy and therapeutic. The laser allows for heating of tissue in the region of infusion, called thermotherapy. Thermotherapy offers the advantages of increasing the volume …
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Engineered microneedles for transcutaneous vaccine delivery
… their surface. Upon topical application, these 'microneedle arrays' are able to safely, and painlessly insert into the immune-competent epidermal skin layers to generate microscopic conduits through which otherwise impermeant vaccines and therapeutics are able to passage into the body. We have …
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Fiberoptic Microneedles for Transdermal Light Delivery
… tissue. To develop this solution, fiber optic microneedles capable of delivering light for therapy were manufactured. We have manufactured fiberoptic microneedles by tapering silica-based optical fibers employing a melt-drawing process. These fiberoptic microneedles were 35 to 139 microns in …
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Microscale polymeric-based technologies for controlled vaccine delivery
… we move forward to a transdermal dissolvable microneedle patch without the need for injections. These microneedle patches can be used to track medical record on patient without the need for expensive healthcare infrastructure--a challenge in developing world. Using extensive computational …
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Novel Delivery Systems For Iron Replenishment
… chemical permeation enhancers, iontophoresis, microneedle pretreatment and combination of these techniques were evaluated and proved to be successful in delivering iron across the skin. When iontophoresis was combined with microneedle pretreatment, adequate iron could be delivered in anemic rat …
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