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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"Microfluidic chip"”.
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Characterization of Mixing in a T-style Microfluidic Chip
… is to characterize the mixing that occurs in a microfluidic chip. To characterize the mixing, the minimum length to complete mixing and evolution of mixing will be investigated. There are two types of mixing that occur within a microfluidic channel, diffusion and advection. In the beginning of …
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Magnetic bead-based DNA extraction and purification microfluidic chip
… trajectories inside the designed extraction chip in order to investigate the efficiency of the magnetic mixing. A preliminary target molecule capturing simulation has also been performed using the simulated bead trajectories to evaluate the DNA-capturing efficiency of the designed extraction …
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Engineered, perfusable, human microvascular networks on a microfluidic chip
… networks on-demand using state of the art microfluidics technology. We have demonstrated the utility of this platform for studying cancer metastasis and as a test bed for drug discovery and analysis. In parallel, this platform enabled us to study, in a highly controlled environment, the …
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Hydrodynamic Focused Passive Separation Under Continuous Flow in a Microfluidic Chip
<p>A continuous flow, passive separation device was designed using an equivalent circuit to create variable flow rates for hydrodynamic focusing to drain channels and collection outlets. By varying the diameter of the sample inlet connection into the reservoir, the particle position was influenced …
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Fabrication of self-assembled zein nanoparticles via microfluidic chip and ultrasonic treatment
… were used to fabricate zein nanoparticles: microfluidic chip and ultrasonic treatment. Microfluidic chips are novel platforms that are used to control the ultra-small volume of fluids going through channels with the dimensions of tens of micrometers. Ultrasound technology has been used in …
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Evaluating Impact of Endothelial Cells on Drug Response of Lung Cancer Spheroids Using Microfluidic Chip
… we used both conventional in vitro systems and a microfluidic platform. The standard in vitro model developed in previous work was used for spheroid generation and as a baseline for comparative analysis. However, it is based on conventional culture format (such as polystirene 24-well plates) which …
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Miniaturised epigenome and interactome screening : development and application of microfluidic ChIP-seq and AP-MS
Contains fulltext : 213664.pdf (Publisher’s version ) (Open Access)
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… pericytes and astrocytes in extravasation. Our microfluidic platform certainly provides advantages over the current state-of-the-art in vitro blood-brain barrier models. While being more physiologically relevant than most in vitro platforms when it comes to geometry, barrier function and …
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3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of …
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Development of a Low Cost Handheld Microfluidic Phosphate Colorimeter for Water Quality Analysis
… design, fabrication, and testing process for a microfluidic phosphate colorimeter utilized for water quality analysis. The device can be powered by, and interfaced for data collection with, a common cell phone or laptop to dramatically reduce costs. Unlike commercially available colorimeters, …
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Loop mediated isothermal amplification based detection of equine respiratory pathogens using a portable, smartphone-based setup
… that interfaces the phone with a silicon-based microfluidic chip embedded within a credit card-sized cartridge. Utilizing specific nucleic acid sequences for four equine respiratory pathogens as representative examples, we demonstrate the ability of the system to utilize a single 15 µL droplet …
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Developing a 3D in vitro Model by Microfluidics
… We pack uniform-sized PEGDA-GelMA microgels in a microfluidic chip to form a 3D porous model. The uniform-sized microgels were fabricated by capillary-based microfluidics; the microfluidic chip was designed and fabricated by soft lithography for conveniently handling gel packing and cell injection …
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Prominent Platforms for the Synthesis of Size-Controllable Polymeric Nanoparticles for Gene Delivery
… the rotor syringe mixing (RSM) system and a microfluidic chip-based system to streamline and ensure the consistency of the NP synthesis process. These platforms offer precise and rigorous control of the parameters of NP synthesis and in turn result in monodis- persed NPs as indicated by the …
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Microfluidic Technology for Low-Input Epigenomic Analysis
… tumorigenesis. Chromatin immunoprecipitation (ChIP) is the technique of choice for examining in vivo DNA-protein interactions and has been a great tool for studying epigenetic mechanisms. However, conventional ChIP assays require millions of cells for tests and are not practical for examination …
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Miniaturisation of pH Holographic Sensors for Nano-Bioreactors
… nL in volume and integrated into a PDMS-glass microfluidic chip for monitoring the growth of Lactobacillus casei Shirota. Although other established methods for monitoring cell cultures can be utilised, miniaturised holosensors enable real-time and non-consumptive monitoring of the bacterial …
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Enabling high-throughput single-cell growth measurements with parallel microchannel resonators
… only been possible to operate a single SMR per microfluidic chip. To enable high-throughput growth measurements, we first developed scalable hardware to operate multiple SMRs on a single chip, utilizing frequency-division multiplexing and a digitally-implemented phase-locked loop array. We call …
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Multiplexed detection of infectious pathogens using on-chip loop-mediated isothermal amplification and a smartphone
… that interfaces the phone with a silicon-based microfluidic chip. Utilizing specific nucleic acid sequences for four equine respiratory pathogens as representative examples, we demonstrated the ability of the system to use a single droplet of test sample to perform selective qualitative …
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Single-cell mass measurements for drug susceptibility testing in cancer
… connected fluidically in parallel on the same microfluidic chip. By operating many mass sensors simultaneously, these "parallel SMR arrays" achieve approximately 27-fold higher throughput than previously possible.
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Development of a portable microfluidic system for monitoring ions river water
… to integrate sample pre-treatment procedures on-chip to allow direct and reproducible analysis of real samples and to investigate the possibility of fabricating an anion exchange column through immobilisation with different ion exchangers using a self-fabricated silica monolithic column.A …
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Development of a portable miniaturised capillary electrophoresis system for chemical nerve agents detection
… Detection) technology applied on a miniaturised microfluidic chip device. The comparison of the practicability of micro-device analysis between high-cost but sophisticated micro/nanofabricated silicon microchip device and with low-cost but disposal polymer microchip. This project output is an …
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