Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Microbead"”.
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Microbead-Based Biosensing in Microfluidic Devices
Microbeads are frequently used as a solid support to capture target analytes of interest, such as proteins and nucleic acids, from a biological sample. The integration of microbeads into microfluidic systems for biological testing is an area of growing interest. Such "lab-on-chip" systems are …
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Chronic Ocular Hypertensive Model using Microbead Injection in Rats: Comparison of Polyurethane, Polymethylmethacrylate, and Polystyrene
… model using intracameral injection with various microbeads of different sizes and materials. Methods: Chronic elevation of intraocular pressure (IOP) was induced by injection of various microbeads into the anterior chamber of Sprague-Dawley rat eyes. We compared the IOPs induced by the injection …
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Point of care platforms for protein and nucleic acid detection
… a microfluidic POC system that correlates microbead capture to IL-6 and PCT concentrations using impedance cytometry, microbead immunoassays, and biotin-streptavidin binding. A multiplexed microbead immunoassay is developed and validated first for the detection of IL-6. The assay principles …
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Hydrodynamic and Mass Transport Properties of Microfluidic Geometries
… examines the heterogeneous binding kinetics in a microbead array, where beads with different chemical functionalities are sequentially captured in a well geometry over which analyte solution is flowed. Finite element simulations identified the flow rates and microbead surface receptor densities at …
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The mechanics of mechanotransduction : analyses of cell perturbation
… cell monolayer produced by forcing one tethered microbead. On the assumption of structural homogeneity, stress and strain patterns were highly localized, suggesting that the effects of magnetocytometry are confined to a region extending less than 10tm from the bead. Modification of the model to …
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The Development of a Bacterial Biosensor Designed to Detect Oxidative Chemicals in Water: Correlating Sensor Relevance to Mammalian Brain Cells and Assessing Bacterial Cell Immobilization Strategies
… of P. aeruginosa in calcium alginate microbeads was evaluated for long-term mechanical stability, viability, and GGKE response of the immobilized cells. The immobilization of cells is an important factor in the design of a whole-cell biosensor, and must yield viable and active cells …
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Spectral properties of semiconductor nanocrystals and their applications
… with particular focus on nanocrystal based microbead barcodes. We present measurements of the temperature dependence of the absorption and emission spectra from 5 sizes of CdSe/ZnS nanocrystal ensembles. Our measurements show that dEabs(T)/dT is similar to the value for bulk CdSe for all …
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Development of a Smartphone Based Point of Care Device for Multiplexed Infectious Disease Diagnosis
… adequate multiplexing capabilities. Quantum dot microbead barcoding, Recombinase Polymerase Amplification and fluorescent microscopy are three technological platforms that have been shown through the work of Chan et al. to be ideal for multiplexed point of care detection when integrated with a …
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Development of a PDMS Based Micro Total Analysis System for Rapid Biomolecule Detection
… reaction between biotin comjugated fluorescent microbeads and streptavidin conjugated paramagnetic microbeads, followed by fluorescence measurements. Based on the performance test results, one of the micromixers was selected for integration. The selected micropump and micromixer were integrated …
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Multiphase, Multicomponent Systems: Divalent Ionic Surfactant Phases and Single-Particle Engineering of Protein and Polymer Glasses
… or bovine serum albumin) results in glassified microbeads with less than a monolayer of water coverage per protein molecule, which can be controlled by the water activity of the surrounding organic medium. The kinetics of dehydration match the prediction of the activity-based model, and it is …
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Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… However, hBMSCs/SSCs attached to a fibrin microbead scaffold coated with hyaluronic acid (HyA-FMBs) produce hyaline-like cartilage for up to 28 weeks <i>in vivo</i>. Therefore, the second goal of my dissertation research was to examine the signalling pathways that govern the development of …
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Goldsmithing technologies, metallurgical traditions and funerary rituals in the Saka societies of the Eurasian Steppe during the Iron Age (c. 900 - 500 BCE)
… of society. These included costume plaques, microbeads, torcs, and gold-decorated armour. Over 300 gold objects, along with several dozen bronze and iron artefacts, originating from two large Early Iron Age necropolises in East Kazakhstan, were analysed using techniques including pXRF, …